Logo
DeutschClear Cookie - decide language by browser settings
Ziegler, Andreas and Kastner, C. (1997): A Minimum Distance Estimation Approach to Estimate the Recombination Fraction from a Marker Locus in Robust Linkage Analysis for Quantitative Traits. Collaborative Research Center 386, Discussion Paper 65
Full text not available from 'Open Access LMU'.

Abstract

Olson and Wijsman (1993) have proposed a robust linkage analysis between quantitative traits and a marker locus using all relative pairs. We extend their work to estimate the recombination fraction using minimum distance estimation after robust linkage analysis requiring a single marker locus. The relevant parameters of the genetic model can also be estimated in the presence of linkage. We illustrate our approach by simulations.