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Batycka-Baran, Aleksandra; Baran, Wojciech; Hryncewicz-Gwozdz, Anita und Burgdorf, Walter H. C. (2010): Dowling-Degos Disease: Case Report and Review of the Literature. In: Dermatology, Nr. 3: S. 254-258 [PDF, 153kB]

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Abstract

Dowling-Degos disease (DDD) is an unusual pigmentary disorder usually caused by mutations in keratin 5. A 44-year-old woman in good general health presented due to the recent appearance of numerous pigmented macules on her axillary and anogenital skin. A biopsy showed lacy, finger-like epidermal extensions into the dermis which were heavily pigmented and associated with tiny cysts or dilated follicles. We view DDD as part of a spectrum of disorders which are morphologically related but vary in location and time of expression. In addition, both the clinical and histological differential diagnostic considerations are extensive. Copyright (C) 2010 S. Karger AG, Basel

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