Venugopal, G. and David, Charles N.
Spatial pattern of nerve differentiation in Hydra is due to a pattern of nerve commitment.
In: Developmental Biology, Vol. 83, No. 2: pp. 366-369
The pattern of nerve differentiation along the body column of Hydra was investigated. Nerve precursors in late S phase were labeled with [3H]thymidine and their distribution compared with that of newly differentiated nerves. The two distributions were found to be the same. Based on independent evidence that nerve commitment occurs in mid-to late S phase (G. Venugopal and C. David, 1981, Develop. Biol.83, 361–365) it was concluded that the pattern of nerve differentiation along the body column of Hydra is due to differences in nerve commitment in different body regions. Furthermore, the level of nerve commitment in head and foot tissue is sufficiently high to deplete stem cells in these regions as is observed.