Stereospecificity of cinnamyl alcohol dehydrogenase and synthesis of stereospecifically labelled coniferyl alcohol

Klischies, Martina and Stöckigt, Joachim and Zenk, Meinhart H. (1978): Stereospecificity of cinnamyl alcohol dehydrogenase and synthesis of stereospecifically labelled coniferyl alcohol. In: Phytochemistry, Vol. 17, No. 9: pp. 1523-1525

Abstract

Using horse liver alcohol dehydrogenase, stereospecifically tritiated (R)- and (S)-(γ-3H)-coniferyl alcohol was synthesized. Using both of these substrates it was demonstrated that cinnamyl alcohol dehydrogenase from lignifying Forsythia tissue specifically removes the pro-R-hydrogen atom of coniferyl alcohol in the oxidation to the aldehyde. This also means that in the reverse reaction the A-hydrogen of NADPH is transferred to the Re-site of coniferyl aldehyde.

• Item Type: Article
• Keywords: Forsythia suspensa; Oleaceae; cinnamyl alcohol oxido-reductase; cinnamyl alcohol; cinnamyl aldehydes; stereospecificity
• Collections: Chemistry and Pharmacy
• Subjects: 500 Science > 540 Chemistry