Synthesis of 1,1,2,2,3,3-hexamethyl-4,5-bis(methylene)cyclopentane

Baran, Janusz and Klein, Herbert and Schade, Christian and Will, Elfriede and Koschinsky, Rainer and Bäuml, Englbert and Mayr, Herbert (1988): Synthesis of 1,1,2,2,3,3-hexamethyl-4,5-bis(methylene)cyclopentane. In: Tetrahedron, Vol. 44, No. 8: pp. 2181-2184

Abstract

An efficient synthesis of the title compound 14 is reported, which employs the ZnCl2/Et2O catalyzed addition of acetyl chloride (4) to 2-methyl-2-butene (5) and the [3+ + 2] cycloaddition of the 1,1,2,3-tetramethylallyl cation to 2,3-dimethyl-2-butene as key steps.

• Item Type: Article
• Collections: Chemistry and Pharmacy
• Subjects: 500 Science > 540 Chemistry