Logo Logo
Hilfe
Hilfe
Switch Language to English

Endres, W.; Ballanyi, Klaus; Serve, G. und Grafe, Peter (1986): Excitatory amino acids and intracellular pH in motoneurons of the isolated frog spinal cord. In: Neuroscience Letters, Bd. 72, Nr. 1: S. 54-58 [PDF, 286kB]

[thumbnail of Grafe_Peter_5502.pdf]
Vorschau
Download (286kB)

Abstract

Double-barrelled pH-sensitive micro-electrodes were used to measure changes of intracellular and extracellular pH in and around motoneurons of the isolated frog spinal cord during application of excitatory amino acids. It was found that N-methyl- -aspartate, quisqualate and kainate produced a concentration-dependent intracellular acidification. Extracellularly, triphasic pH changes (acid-alkaline-acid going pH transients) were observed during the action of these amino acids. The possible significance of such pH changes for the physiological and pathophysiological effects of excitatory amino acids are discussed.

Dokument bearbeiten Dokument bearbeiten