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Nicholson, Donald W. and Neupert, Walter (1989): Import of cytochrome c into mitochondria. Reduction of heme, mediated by NADH and flavin nucleotides, is obligatory for its covalent linkage to apocytochrome c. In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 86, No. 12: pp. 4340-4344.

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Official URL: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=287264

Abstract

The covalent attachment of heme to apocytochrome c, and therefore the import of cytochrome c into mitochondria, is dependent on both NADH plus a cytosolic cofactor that has been identified to be FMN or FAD. NADH in concert with flavin nucleotides mediates the reduction of heme. Heme in the reduced state is a prerequisite for its covalent attachment to apocytochrome c by the enzyme cytochrome c heme lyase and thus for subsequent translocation of cytochrome c across the outer mitochondrial membrane during import.

Item Type:Article
Subjects:Medicine
Dewey Classification:600 Technology, Medicine
600 Technology, Medicine > 610 Medical sciences and medicine
URN:urn:nbn:de:bvb:19-epub-7499-5
ID Code:7499
Deposited On:17. Nov 2008 16:17
Last Modified:28. Jun 2010 15:11
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