Pfanner, Nikolaus and Rassow, Joachim and Wienhues, Ulla and Hergersberg, Christoph and Söllner, Thomas and Becker, Karin and Neupert, Walter
Contact sites between inner and outer membranes. Structure and role in protein translocation into the mitochondria.
In: Biochimica et Biophysica Acta (BBA) - Bioenergetics, Vol. 1018, No. 2-3: pp. 239-242
Contact sites between both mitochondrial membranes play a predominant role in the transport of nuclear-coded precursor proteins into mitochondria. The characterization of contact sites was greatly advanced by the reversible accumulation of precursor proteins in transit (translocation intermediates). It was found that the sites are saturable, apparently contain proteinaceous components and mediate extensive unfolding of the polypeptide chain in translocation. Some components of mitochondrial contact sites are currently being identified.