Mitochondrial import receptors for precursor proteins

Pfanner, Nikolaus and Söllner, Thomas and Neupert, Walter (1991): Mitochondrial import receptors for precursor proteins. In: Trends in Biochemical Sciences, Vol. 16: pp. 63-67

Abstract

The specific targeting of precursor proteins synthesized in the cytosol to various cell organelles is a central aspect of intracellular protein traffic. Several hundred different proteins are imported from the cytosol into the mitochondria. Recent studies have identified the mitochondrial outer membrane proteins MOM19, MOM72, MOM38 (≈ISP42) and p32 which have a role in initial steps of protein import. The first three components are present in a multi-subunit complex that catalyses recognition and membrane insertion of precursor proteins.

• Item Type: Article
• Collections: Medicine
• Subjects: 600 Technology > 610 Medicine and health