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Gruppiert nach: Dokumententyp | Veröffentlichungsdatum
Anzahl der Publikationen: 54

Zeitschriftenartikel

Scotto Rosato, Anna; Krogsaeter, Einar K; Jaślan, Dawid; Abrahamian, Carla; Montefusco, Sandro; Soldati, Chiara; Spix, Barbara; Pizzo, Maria Teresa; Grieco, Giuseppina; Böck, Julia; Wyatt, Amanda; Wünkhaus, Daniela; Passon, Marcel; Stieglitz, Marc; Keller, Marco; Hermey, Guido; Markmann, Sandra; Gruber‐Schoffnegger, Doris; Cotman, Susan; Johannes, Ludger; Crusius, Dennis; Boehm, Ulrich; Wahl-Schott, Christian; Biel, Martin; Bracher, Franz; De Leonibus, Elvira; Polishchuk, Elena; Medina, Diego L; Paquet, Dominik und Grimm, Christian (5. August 2022): TPC2 rescues lysosomal storage in mucolipidosis type IV , Niemann–Pick type C1, and Batten disease. In: EMBO Molecular Medicine, Bd. 14, Nr. 9 [PDF, 27MB]

Geisslinger, Franz; Müller, Martin; Chao, Yu-Kai; Grimm, Christian; Vollmar, Angelika M. und Bartel, Karin (1. August 2022): Targeting TPC2 sensitizes acute lymphoblastic leukemia cells to chemotherapeutics by impairing lysosomal function. In: Cell Death & Disease, Bd. 13, Nr. 8 [PDF, 5MB]

Castro, Sandra Prat; Kudrina, Veronika; Jaslan, Dawid; Boeck, Julia; Rosato, Anna Scotto und Grimm, Christian (2022): Neurodegenerative Lysosomal Storage Disorders: TPC2 Comes to the Rescue! In: Cells, Bd. 11, Nr. 18, 2807

Spix, Barbara; Butz, Elisabeth S.; Chen, Cheng-Chang; Rosato, Anna Scotto; Tang, Rachel; Jeridi, Aicha; Kudrina, Veronika; Plesch, Eva; Wartenberg, Philipp; Arlt, Elisabeth; Briukhovetska, Daria; Ansari, Meshal; Günsel, Gizem Günes; Conlon, Thomas M.; Wyatt, Amanda; Wetzel, Sandra; Teupser, Daniel; Holdt, Lesca M.; Ectors, Fabien; Boekhoff, Ingrid; Boehm, Ulrich; García-Añoveros, Jaime; Saftig, Paul; Giera, Martin; Kobold, Sebastian; Schiller, Herbert B.; Zierler, Susanna; Gudermann, Thomas; Wahl-Schott, Christian; Bracher, Franz; Yildirim, Ali Önder; Biel, Martin und Grimm, Christian (2022): Lung emphysema and impaired macrophage elastase clearance in mucolipin 3 deficient mice. In: Nature Communications, Bd. 13, 318 [PDF, 3MB]

Grimm, Christian; Hainzl, Sebastian; Käser, Martin und Küchenhoff, Helmut (2022): Solving three major biases of the ETAS model to improve forecasts of the 2019 Ridgecrest sequence. In: Stochastic Environmental Research and Risk Assessment, Bd. 36, Nr. 8: S. 2133-2152 [PDF, 4MB]

Grimm, Christian; Kaeser, Martin; Hainzl, Sebastian; Pagani, Marco und Kuechenhoff, Helmut (2022): Improving Earthquake Doublet Frequency Predictions by Modified Spatial Trigger Kernels in the Epidemic-Type Aftershock Sequence (ETAS) Model. In: Bulletin of the Seismological Society of America, Bd. 112, Nr. 1: S. 474-493

Fernandez, Belen; Olmedo, Pablo; Gil, Fernando; Fdez, Elena; Naaldijk, Yahaira; Rivero-Rios, Pilar; Bracher, Franz; Grimm, Christian; Churchill, Grant C. und Hilfiker, Sabine (2022): Iron-induced cytotoxicity mediated by endolysosomal TRPML1 channels is reverted by TFEB. In: Cell Death & Disease, Bd. 13, Nr. 12, 1047

Siow, Wei Xiong; Kabiri, Yaschar; Tang, Rachel; Chao, Yu-Kai; Plesch, Eva; Eberhagen, Carola; Flenkenthaler, Florian; Froehlich, Thomas; Bracher, Franz; Grimm, Christian; Biel, Martin; Zischka, Hans; Vollmar, Angelika M. und Bartel, Karin (2022): Lysosomal TRPML1 regulates mitochondrial function in hepatocellular carcinoma cells. In: Journal of Cell Science, Bd. 135, Nr. 6, jcs259455

Yuan, Yu; Jaslan, Dawid; Rahman, Taufiq; Bolsover, Stephen R.; Arige, Vikas; Wagner, Larry E.; Abrahamian, Carla; Tang, Rachel; Keller, Marco; Hartmann, Jonas; Rosato, Anna S.; Weiden, Eva-Maria; Bracher, Franz; Yule, David I.; Grimm, Christian und Patel, Sandip (2022): Segregated cation flux by TPC2 biases Ca2+ signaling through lysosomes. In: Nature Communications, Bd. 13, Nr. 1, 4481

Patel, Sandip; Yuan, Yu; Chen, Cheng-Chang; Jaslan, Dawid; Gunaratne, Gihan; Grimm, Christian; Rahman, Taufiq und Marchant, Jonathan S. (2022): Electrophysiology of Endolysosomal Two-Pore Channels: A Current Account. In: Cells, Bd. 11, Nr. 15, 2368

Krogsaeter, Einar; Rosato, Anna Scotto und Grimm, Christian (2022): TRPMLs and TPCs: Targets for lysosomal storage and neurodegenerative disease therapy? In: Cell Calcium, Bd. 103, 102553

Jaslan, Dawid; Ferro, Irene Flavia; Kudrina, Veronika; Yuan, Yu; Patel, Sandip und Grimm, Christian (2022): PI(3,5)P2 and NAADP: Team players or lone warriors?-New insights into TPC activation modes. In: Cell Calcium, Bd. 109, 102675

Spix, Barbara; Castiglioni, Andrew J.; Remis, Natalie N.; Flores, Emma N.; Wartenberg, Philipp; Wyatt, Amanda; Boehm, Ulrich; Gudermann, Thomas; Biel, Martin; Garcia-Anoveros, Jaime und Grimm, Christian (2022): Whole-body analysis of TRPML3 (MCOLN3) expression using a GFP-reporter mouse model reveals widespread expression in secretory cells and endocrine glands.
In: PLOS One 17(12), e0278848

Spix, Barbara; Jeridi, Aicha; Ansari, Meshal; Yildirim, Ali Oender; Schiller, Herbert B. und Grimm, Christian (2022): Endolysosomal Cation Channels and Lung Disease. In: Cells, Bd. 11, Nr. 2, 304

Yuan, Yu; Kilpatrick, Bethan S.; Gerndt, Susanne; Bracher, Franz; Grimm, Christian; Schapira, Anthony H. und Patel, Sandip (2021): The lysosomotrope GPN mobilises Ca2+ from acidic organelles. In: Journal of Cell Science, Bd. 134, Nr. 6, jcs256578

Abrahamian, Carla und Grimm, Christian (2021): Endolysosomal Cation Channels and MITF in Melanocytes and Melanoma. In: Biomolecules, Bd. 11, Nr. 7, 1021

Böck, Julia; Krogsaeter, Einar; Passon, Marcel; Chao, Yu-Kai; Sharma, Sapna; Grallert, Harald; Peters, Annette und Grimm, Christian (2021): Human genome diversity data reveal that L564P is the predominant TPC2 variant and a prerequisite for the blond hair associated M484L gain-of-function effect.
In: PLOS Genetics 17(1), e1009236

Chen, Cheng-Chang; Krogsaeter, Einar und Grimm, Christian (2021): Two-pore and TRP cation channels in endolysosomal osmo-/mechanosensation and volume regulation. In: Biochimica et Biophysica Acta-Molecular Cell Research, Bd. 1868, Nr. 2, 118921

Netcharoensirisuk, Ponsawan; Abrahamian, Carla; Tang, Rachel; Chen, Cheng-Chang; Rosato, Anna Scotto; Beyers, Wyatt; Chao, Yu-Kai; Filippini, Antonio; Di Pietro, Santiago; Bartel, Karin; Biel, Martin; Vollmar, Angelika M.; Umehara, Kaoru; De-Eknamkul, Wanchai und Grimm, Christian (2021): Flavonoids increase melanin production and reduce proliferation, migration and invasion of melanoma cells by blocking endolysosomal/melanosomal TPC2. In: Scientific reports, Bd. 11, Nr. 1, 8515 [PDF, 4MB]

Rühl, Philipp; Rosato, Anna Scotto; Urban, Nicole; Gerndt, Susanne; Tang, Rachel; Abrahamian, Carla; Leser, Charlotte; Sheng, Jiansong; Jha, Archana; Vollmer, Günter; Schaefer, Michael; Bracher, Franz ORCID logoORCID: https://orcid.org/0000-0003-0009-8629 und Grimm, Christian (2021): Estradiol analogs attenuate autophagy, cell migration and invasion by direct and selective inhibition of TRPML1, independent of estrogen receptors. In: Scientific reports, Bd. 11, Nr. 1, 8313 [PDF, 7MB]

Leser, Charlotte; Keller, Marco; Gerndt, Susanne; Urban, Nicole; Chen, Cheng-Chang; Schaefer, Michael; Grimm, Christian und Bracher, Franz (2021): Chemical and pharmacological characterization of the TRPML calcium channel blockers ML-SI1 and ML-SI3. In: European Journal of Medicinal Chemistry, Bd. 210, 112966

Li, Yanfen; Schoen, Christian; Chen, Cheng-Chang; Yang, Zhuo; Liegl, Raffael; Murenu, Elisa; Schworm, Benedikt; Klugbauer, Norbert; Grimm, Christian; Wahl-Schott, Christian; Michalakis, Stylianos und Biel, Martin (2021): TPC2 promotes choroidal angiogenesis and inflammation in a mouse model of neovascular age-related macular degeneration. In: Life Science Alliance, Bd. 4, Nr. 8, e202101047

Müller, Martin; Gerndt, Susanne; Chao, Yu-Kai; Zisis, Themistoklis; Ong, Nam Phuong Nguyen; Gerwien, Aaron; Urban, Nicole; Müller, Christoph; Gegenfurtner, Florian A.; Geisslinger, Franz; Ortler, Carina; Chen, Cheng-Chang; Zahler, Stefan; Biel, Martin; Schäfer, Michael; Grimm, Christian; Bracher, Franz; Vollmar, Angelika M. und Bartel, Karin (2021): Gene editing and synthetically accessible inhibitors reveal role for TPC2 in HCC cell proliferation and tumor growth. In: Cell Chemical Biology, Bd. 28, Nr. 8: 1119-

Ruehl, Philipp; Rosato, Anna Scotto; Urban, Nicole; Gerndt, Susanne; Tang, Rachel; Abrahamian, Carla; Leser, Charlotte; Sheng, Jiansong; Jha, Archana; Vollmer, Guenter; Schaefer, Michael; Bracher, Franz und Grimm, Christian (2021): Estradiol analogs attenuate autophagy, cell migration and invasion by direct and selective inhibition of TRPML1, independent of estrogen receptors. In: Scientific Reports, Bd. 11, Nr. 1, 8313

Clement, Dennis; Goodridge, Jodie P.; Grimm, Christian; Patel, Sandip und Malmberg, Karl-Johan (April 2020): TRP Channels as Interior Designers: Remodeling the Endolysosomal Compartment in Natural Killer Cells. In: Frontiers in Immunology, Bd. 11, 753: S. 1-15 [PDF, 990kB]

Spix, Barbara; Chao, Yu-Kai; Abrahamian, Carla; Chen, Cheng-Chang und Grimm, Christian (Februar 2020): TRPML Cation Channels in Inflammation and Immunity. In: Frontiers in Immunology, Bd. 11, 225: S. 1-9 [PDF, 747kB]

Gerndt, Susanne; Chen, Cheng-Chang; Chao, Yu-Kai; Yuan, Yu; Burgstaller, Sandra; Rosato, Anna Scotto; Krogsaeter, Einar; Urban, Nicole; Jacob, Katharina; Ong, Nam Phuong Nguyen; Miller, Meghan T.; Keller, Marco; Vollmar, Angelika M.; Gudermann, Thomas; Zierler, Susanna; Schredelseker, Johann; Schaefer, Michael; Biel, Martin; Malli, Roland; Wahl-Schott, Christian; Bracher, Franz; Patel, Sandip und Grimm, Christian (2020): Agonist-mediated switching of ion selectivity in TPC2 differentially promotes lysosomal function. In: eLife, Bd. 9, e54712 [PDF, 4MB]

Jaslan, Dawid; Boeck, Julia; Krogsaeter, Einar und Grimm, Christian (2020): Evolutionary Aspects of TRPMLs and TPCs. In: International Journal of Molecular Sciences, Bd. 21, Nr. 11, 4181

Gerndt, Susanne; Krogsaeter, Einar; Patel, Sandip; Bracher, Franz und Grimm, Christian (2020): Discovery of lipophilic two-pore channel agonists. In: FEBS Journal, Bd. 287, Nr. 24: S. 5284-5293 [PDF, 2MB]

Weber, Jonas; Rajan, Suhasini; Schremmer, Christian; Chao, Yu-Kai; Krasteva-Christ, Gabriela; Kannler, Martina; Yildirim, Ali Onder; Brosien, Monika; Schredelseker, Johann; Weissmann, Norbert; Grimm, Christian; Gudermann, Thomas und Dietrich, Alexander (2020): TRPV4 channels are essential for alveolar epithelial barrier function as protection from lung edema. In: Jci Insight, Bd. 5, Nr. 20, e134464

Chen, Cheng-Chang; Krogsaeter, Einar; Butz, Elisabeth S.; Li, Yanfen; Puertollano, Rosa; Wahl-Schott, Christian; Biel, Martin und Grimm, Christian (2020): TRPML2 is an osmo/mechanosensitive cation channel in endolysosomal organelles. In: Science Advances, Bd. 6, Nr. 46, eabb5064

Arlt, Elisabeth; Fraticelli, Marco; Tsvilovskyy, Volodymyr; Nadolni, Wiebke; Breit, Andreas; O'Neill, Thomas J.; Resenberger, Stefanie; Wennemuth, Gunther; Wahl-Schott, Christian; Biel, Martin; Grimm, Christian; Freichel, Marc; Gudermann, Thomas; Klugbauer, Norbert; Boekhoff, Ingrid und Zierler, Susanna (2020): TPC1 deficiency or blockade augments systemic anaphylaxis and mast cell activity. In: Proceedings of the National Academy of Sciences of the United States of America, Bd. 117, Nr. 30: S. 18068-18078

Villella, Valeria R.; Venerando, Andrea; Cozza, Giorgio; Esposito, Speranza; Ferrari, Eleonora; Monzani, Romina; Spinella, Mara C.; Oikonomou, Vasilis; Renga, Giorgia; Tosco, Antonella; Rossin, Federica; Guido, Stefano; Silano, Marco; Garaci, Enrico; Chao, Yu-Kai; Grimm, Christian; Luciani, Alessandro; Romani, Luigina; Piacentini, Mauro; Raia, Valeria; Kroemer, Guido und Maiuri, Luigi (2019): A pathogenic role for cystic fibrosis transmembrane conductance regulator in celiac disease. In: EMBO Journal, Bd. 38, Nr. 2, e100101

Goodridge, Jodie P.; Jacobs, Benedikt; Saetersmoen, Michelle L.; Clement, Dennis; Hammer, Quirin; Clancy, Trevor; Skarpen, Ellen; Brech, Andreas; Landskron, Johannes; Grimm, Christian; Pfefferle, Aline; Meza-Zepeda, Leonardo; Lorenz, Susanne; Wiiger, Merete Thune; Louch, William E.; Ask, Eivind Heggernes; Liu, Lisa L.; Oei, Vincent Yi Sheng; Kjallquist, Una; Linnarsson, Sten; Patel, Sandip; Tasken, Kjetil; Stenmark, Harald und Malmberg, Karl-Johan (2019): Remodeling of secretory lysosomes during education tunes functional potential in NK cells. In: Nature Communications, Bd. 10, 514 [PDF, 3MB]

Krogsaeter, Einar K.; Biel, Martin; Wahl-Schott, Christian und Grimm, Christian (2019): The protein interaction networks of mucolipins and two-pore channels. In: Biochimica et Biophysica Acta-Molecular Cell Research, Bd. 1866, Nr. 7: S. 1111-1123

Barben, Maya; Ail, Divya; Storti, Federica; Klee, Katrin; Schori, Christian; Samardzija, Marijana; Michalakis, Stylianos; Biel, Martin; Meneau, Isabelle; Blaser, Frank; Barthelmes, Daniel und Grimm, Christian (2018): Hif1a inactivation rescues photoreceptor degeneration induced by a chronic hypoxia-like stress. In: Cell Death and Differentiation, Bd. 25, Nr. 12: S. 2071-2085 [PDF, 6MB]

Grimm, Christian; Bartel, Karin; Vollmar, Angelika M. und Biel, Martin (2018): Endolysosomal Cation Channels and Cancer-A Link with Great Potential. In: Pharmaceuticals, Bd. 11, Nr. 1 [PDF, 782kB]

Plesch, Eva; Chen, Cheng-Chang; Butz, Elisabeth; Rosato, Anna Scotto; Krogsaeter, Einar K.; Yinan, Hua; Bartel, Karin; Keller, Marco; Robaa, Dina; Teupser, Daniel; Holdt, Lesca M.; Vollmar, Angelika M.; Sippl, Wolfgang; Puertollano, Rosa; Medina, Diego; Biel, Martin; Wahl-Schott, Christian; Bracher, Franz und Grimm, Christian (2018): Selective agonist of TRPML2 reveals direct role in chemokine release from innate immune cells. In: eLife, Bd. 7, e39720 [PDF, 4MB]

Grimm, Christian; Chen, Cheng-Chang; Wahl-Schott, Christian und Biel, Martin (Februar 2017): Two-Pore Channels: Catalyzers of Endolysosomal Transport and Function. In: Frontiers in Pharmacology, Bd. 8, 45 [PDF, 662kB]

Nguyen, Ong Nam Phuong; Grimm, Christian; Schneider, Lina S.; Chao, Yu-Kai; Atzberger, Carina; Bartel, Karin; Watermann, Anna; Ulrich, Melanie; Mayr, Doris; Wahl-Schott, Christian; Biel, Martin und Vollmar, Angelika M. (2017): Two-Pore Channel Function Is Crucial for the Migration of Invasive Cancer Cells. In: Cancer Research, Bd. 77, Nr. 6: S. 1427-1438

Chao, Yu-Kai; Schludi, Verena; Chen, Cheng-Chang; Butz, Elisabeth; Nguyen, O. N. Phuong; Müller, Martin; Krüger, Jens; Kammerbauer, Claudia; Ben-Johny, Manu; Vollmar, Angelika M.; Berking, Carola; Biel, Martin; Wahl-Schott, Christian A. und Grimm, Christian (2017): TPC2 polymorphisms associated with a hair pigmentation phenotype in humans result in gain of channel function by independent mechanisms. In: Proceedings of the National Academy of Sciences of the United States of America, Bd. 114, Nr. 41, E8595-E8602

Grimm, Christian; Butz, Elisabeth; Chen, Cheng-Chang; Wahl-Schott, Christian und Biel, Martin (2017): From mucolipidosis type IV to Ebola: TRPML and two-pore channels at the crossroads of endo-lysosomal trafficking and disease. In: Cell Calcium, Bd. 67: S. 148-155

Castonguay, Jan; Orth, Joachim H. C.; Müller, Thomas; Sleman, Faten; Grimm, Christian; Wahl-Schott, Christian; Biel, Martin; Mallmann, Robert Theodor; Bildl, Wolfgang; Schulte, Uwe und Klugbauer, Norbert (2017): The two-pore channel TPC1 is required for efficient protein processing through early and recycling endosomes. In: Scientific Reports, Bd. 7, 10038 [PDF, 4MB]

Chen, Cheng-Chang; Cang, Chunlei; Fenske, Stefanie; Butz, Elisabeth; Chao, Yu-Kai; Biel, Martin; Ren, Dejian; Wahl-Schott, Christian und Grimm, Christian (2017): Patch-clamp technique to characterize ion channels in enlarged individual endolysosomes. In: Nature Protocols, Bd. 12, Nr. 8: S. 1639-1658

Chen, Cheng-Chang; Butz, Elisabeth S.; Chao, Yu-Kai; Grishchuk, Yulia; Becker, Lars; Heller, Stefan; Slaugenhaupt, Susan A.; Biel, Martin; Wahl-Schott, Christian und Grimm, Christian (2017): Small Molecules for Early Endosome-Specific Patch Clamping. In: Cell Chemical Biology, Bd. 24, Nr. 7: S. 907-916

Bobak, Nicole; Feliciangeli, Sylvain; Chen, Cheng-Chang; Ben Soussia, Ismail; Bittner, Stefan; Pagnotta, Sophie; Ruck, Tobias; Biel, Martin; Wahl-Schott, Christian; Grimm, Christian; Meuth, Sven G. und Lesage, Florian (2017): Recombinant tandem of pore-domains in a Weakly Inward rectifying K+ channel 2 (TWIK2) forms active lysosomal channels. In: Scientific Reports, Bd. 7, 649 [PDF, 11MB]

Grimm, Christian; Barben, Maya; Ail, Divya; Kast, Brigitt; Schori, Christian; Giger-Lange, Christina; Michalakis, Stylianos und Samardzija, Marijana (2016): Inactivation of Hif1a rescues rods and cones from degeneration induced by a chronic hypoxia-like response: HIF1A as therapeutic target in AMD? In: Investigative Ophthalmology & Visual Science, Bd. 57, Nr. 12

Kilpatrick, Bethan S.; Yates, Elizabeth; Grimm, Christian; Schapira, Anthony H. und Patel, Sandip (2016): Endo-lysosomal TRP mucolipin-1 channels trigger global ER Ca2+ release and Ca2+ influx. In: Journal of Cell Science, Bd. 129, Nr. 20: S. 3859-3867

Beck, Simon; Henß, Lisa; Weidner, Tatjana; Herrmann, Jennifer; Müller, Rolf; Chao, Yu-Kai; Grimm, Christian; Weber, Christopher; Sliva, Katja und Schnierle, Barbara S. (2016): Identification of entry inhibitors of Ebola virus pseudotyped vectors from a myxobacterial compound library. In: Antiviral Research, Bd. 132: S. 85-91

Grimm, Christian; Holdt, Lesca M.; Chen, Cheng-Chang; Hassan, Sami; Müller, Christoph; Jörs, Simone; Cuny, Hartmut; Kissing, Sandra; Schröder, Bernd; Butz, Elisabeth; Northoff, Bernd; Castonguay, Jan; Luber, Christian A.; Moser, Markus; Spahn, Saskia; Luellmann-Rauch, Renate; Fendel, Christina; Klugbauer, Norbert; Griesbeck, Oliver; Haas, Albert; Mann, Matthias; Bracher, Franz; Teupser, Daniel; Saftig, Paul; Biel, Martin und Wahl-Schott, Christian (2014): High susceptibility to fatty liver disease in two-pore channel 2-deficient mice. In: Nature Communications, Bd. 5, 4699 [PDF, 3MB]

Chen, Cheng-Chang; Keller, Marco; Hess, Martin; Schiffmann, Raphael; Urban, Nicole; Wolfgardt, Annette; Schaefer, Michael; Bracher, Franz; Biel, Martin; Wahl-Schott, Christian und Grimm, Christian (2014): A small molecule restores function to TRPML1 mutant isoforms responsible for mucolipidosis type IV. In: Nature Communications, Bd. 5, 4681 [PDF, 1MB]

Guo, Zhaohua; Grimm, Christian; Becker, Lars; Ricci, Anthony J. und Heller, Stefan (2013): A novel ion channel formed by interaction of TRPML3 with TRPV5.
In: PLOS ONE 8(2), e58174 [PDF, 893kB]

Fischer, M. Dominik; Huber, Gesine; Beck, Susanne C.; Tanimoto, Naoyuki; Muehlfriedel, Regine; Fahl, Edda; Grimm, Christian; Wenzel, Andreas; Remé, Charlotte E.; van de Pavert, Serge A.; Wijnholds, Jan; Pacal, Marek; Bremner, Rod und Seeliger, Mathias W. (2009): Noninvasive, in vivo assessment of mouse retinal structure using optical coherence tomography.
In: PLOS ONE 4(10), e7507 [PDF, 1MB]

Zeitungsartikel

Grimm, Christian (22. Juni 2020): "Ursache ist ein Gendefekt". In: Münchner Merkur: S. 8

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