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Anzahl der Publikationen: 37
Zeitschriftenartikel
Chou, Jinjiang; Kaller, Markus; Jaeckel, Stephanie; Rokavec, Matjaz und Hermeking, Heiko
(27. Mai 2022):
AP4 suppresses DNA damage, chromosomal instability and senescence via inducing MDC1/Mediator of DNA damage Checkpoint 1 and repressing MIR22HG/miR-22-3p.
In: Molecular Cancer, Bd. 21
[PDF, 13MB]
Wirth, Anna-Katharina; Wange, Lucas; Vosberg, Sebastian; Henrich, Kai-Oliver; Rausch, Christian; Oezdemir, Erbey; Zeller, Christina M.; Richter, Daniel; Feuchtinger, Tobias; Kaller, Markus; Hermeking, Heiko; Greif, Philipp A.; Senft, Daniela; Jurinovic, Vindi; Bahrami, Ehsan; Jayavelu, Ashok Kumar; Westermann, Frank; Mann, Matthias; Enard, Wolfgang; Herold, Tobias und Jeremias, Irmela
(2022):
In vivo PDX CRISPR/Cas9 screens reveal mutual therapeutic targets to overcome heterogeneous acquired chemo-resistance.
In: Leukemia, Bd. 36: S. 2863-2874
Metzger, Rebecca; Winter, Lis; Bouznad, Nassim; Garzetti, Debora; Armansperg, Benedikt von; Rokavec, Matjaz; Lutz, Konstantin; Schafer, Yvonne; Krebs, Sabrina; Winheim, Elena; Friedrich, Verena; Matzek, Dana; Oellinger, Rupert; Rad, Roland; Stecher, Barbel; Hermeking, Heiko; Brocker, Thomas und Krug, Anne B.
(2022):
CCL17 Promotes Colitis-Associated Tumorigenesis Dependent on the Microbiota.
In: Journal of Immunology, Bd. 209, Nr. 11: S. 2227-2238
Loevenich, Leon P.; Tschurtschenthaler, Markus; Rokavec, Matjaz; Silva, Miguel G.; Jesinghaus, Moritz; Kirchner, Thomas; Klauschen, Frederick; Saur, Dieter; Neumann, Jens; Hermeking, Heiko und Jung, Peter
(2022):
SMAD4 Loss Induces c-MYC-Mediated NLE1 Upregulation to Support Protein Biosynthesis, Colorectal Cancer Growth, and Metastasis.
In: Cancer Research, Bd. 82, Nr. 24: S. 4604-4623
Boos, Sophie L.; Loevenich, Leon P.; Vosberg, Sebastian; Engleitner, Thomas; Öllinger, Rupert; Kumbrink, Joerg; Rokavec, Matjaz; Michl, Marlies; Greif, Philipp A.; Jung, Andreas; Hermeking, Heiko; Neumann, Jens; Kirchner, Thomas; Rad, Roland und Jung, Peter
(2022):
Disease Modeling on Tumor Organoids Implicates AURKA as a Therapeutic Target in Liver Metastatic Colorectal Cancer.
In: Cellular and Molecular Gastroenterology and Hepatology, Bd. 13, Nr. 2: S. 517-540
Liu, Fangteng; Bouznad, Nassim; Kaller, Markus; Shi, Xiaolong; König, Janine; Jaeckel, Stephanie und Hermeking, Heiko
(2022):
Csf1r mediates enhancement of intestinal tumorigenesis caused by inactivation of Mir34a.
In: International Journal of Biological Sciences, Bd. 18, Nr. 14: S. 5415-5437
[PDF, 6MB]
Siemens, Helge; Neumann, Jens; Jackstadt, Rene; Mansmann, Ulrich 
ORCID: https://orcid.org/0000-0002-9955-8906; Horst, David; Kirchner, Thomas und Hermeking, Heiko
(2022):
Correction: Detection of miR-34a Promoter Methylation in Combination with Elevated Expression of c-Met and β-Catenin Predicts Distant Metastasis of Colon Cancer.
In: Clinical Cancer Research, Bd. 28, Nr. 8: S. 1739
ORCID: https://orcid.org/0000-0002-9955-8906; Horst, David; Kirchner, Thomas und Hermeking, Heiko
(2022):
Correction: Detection of miR-34a Promoter Methylation in Combination with Elevated Expression of c-Met and β-Catenin Predicts Distant Metastasis of Colon Cancer.
In: Clinical Cancer Research, Bd. 28, Nr. 8: S. 1739
Winter, Markus; Rokavec, Matjaz und Hermeking, Heiko
(2021):
14-3-3 sigma Functions as an Intestinal Tumor Suppressor.
In: Cancer Research, Bd. 81, Nr. 13: S. 3621-3634
Gatsiou, Aikaterini; Georgiopoulos, Georgios; Vlachogiannis, Nikolaos I.; Pfisterer, Larissa; Fischer, Ariane; Sachse, Marco; Laina, Ageliki; Bonini, Francesca; Delialis, Dimitrios; Tual-Chalot, Simon; Zormpas, Eleftherios; Achangwa, Rawlings; Jiang, Longchang; Kontogiannis, Christos; Patras, Raphael; Hermeking, Heiko; Zeiher, Andreas M.; Stamatelopoulos, Kimon; Dimmeler, Stefanie und Stellos, Konstantinos
(2021):
Additive contribution of microRNA-34a/b/c to human arterial ageing and atherosclerosis.
In: Atherosclerosis, Bd. 327: S. 49-58
Iftekhar, Amina; Berger, Hilmar; Bouznad, Nassim; Heuberger, Julian; Boccellato, Francesco; Dobrindt, Ulrich; Hermeking, Heiko; Sigal, Michael und Meyer, Thomas F.
(2021):
Genomic aberrations after short-term exposure to colibactin-producing E. coli transform primary colon epithelial cells.
In: Nature Communications, Bd. 12, Nr. 1, 1003
Wong, Matthew Man-Kin; Joyson, Sancy Mary; Hermeking, Heiko und Chiu, Sung Kay
(2021):
Transcription Factor AP4 Mediates Cell Fate Decisions: To Divide, Age, or Die.
In: Cancers, Bd. 13, Nr. 4, 676
Dietinger, Vanessa; de Durango, Cira R. Garcia; Wiechmann, Svenja; Boos, Sophie L.; Michl, Marlies; Neumann, Jens; Hermeking, Heiko; Kuster, Bernhard und Jung, Peter
(2020):
Wnt-driven LARGE2 mediates laminin-adhesive O-glycosylation in human colonic epithelial cells and colorectal cancer.
In: Cell Communication and Signaling, Bd. 18, Nr. 1, 102
Hidalgo-Sastre, Ana; Lubeseder-Martellato, Clara; Engleitner, Thomas; Steiger, Katja; Zhong, Suyang; Desztics, Judit; Öllinger, Rupert; Rad, Roland; Schmid, Roland M.; Hermeking, Heiko; Siveke, Jens T. und Figura, Guido von
(2020):
Mir34a constrains pancreatic carcinogenesis.
In: Scientific Reports, Bd. 10, Nr. 1, 9654
[PDF, 4MB]
Shi, Xiaolong; Kaller, Markus; Rokavec, Matjaz; Kirchner, Thomas; Horst, David und Hermeking, Heiko
(2020):
Characterization of a p53/miR-34a/CSF1R/STAT3 Feedback Loop in Colorectal Cancer.
In: Cellular and Molecular Gastroenterology and Hepatology, Bd. 10, Nr. 2: S. 391-418
Rokavec, Matjaz; Bouznad, Nassim und Hermeking, Heiko
(2019):
Paracrine Induction of Epithelial-Mesenchymal Transition Between Colorectal Cancer Cells and its Suppression by a p53/miR-192/215/NID1 Axis.
In: Cellular and Molecular Gastroenterology and Hepatology, Bd. 7, Nr. 4: S. 783-802
Oener, Meryem Guelfem; Rokavec, Matjaz; Kaller, Markus; Bouznad, Nassim; Horst, David; Kirchner, Thomas und Hermeking, Heiko
(2018):
Combined Inactivation of TP53 and MIR34A Promotes Colorectal Cancer Development and Progression in Mice Via Increasing Levels of IL6R and PAI1.
In: Gastroenterology, Bd. 155, Nr. 6: S. 1868-1882
Schmidt, Eva Marina; Lamprecht, Sebastian; Blaj, Cristina; Schaaf, Christian; Krebs, Stefan; Blum, Helmut; Hermeking, Heiko; Jung, Andreas; Kirchner, Thomas und Horst, David
(2018):
Targeting tumor cell plasticity by combined inhibition of NOT CH and MAPK signaling in colon cancer.
In: Journal of Experimental Medicine, Bd. 215, Nr. 6: S. 1693-1708
Jaeckel, Stephanie; Kaller, Markus; Jackstadt, Rene; Götz, Ursula; Müller, Susanna; Boos, Sophie; Horst, David; Jung, Peter und Hermeking, Heiko
(2018):
Ap4 is rate limiting for intestinal tumor formation by controlling the homeostasis of intestinal stem cells.
In: Nature Communications, Bd. 9, 3573
[PDF, 3MB]
Lamprecht, Sebastian; Kaller, Markus; Schmidt, Eva Marina; Blaj, Cristina; Schiergens, Tobias S.; Engel, Jutta; Jung, Andreas; Hermeking, Heiko; Grünewald, Thomas G. P.; Kirchner, Thomas und Horst, David
(2018):
PBX3 Is Part of an EMT Regulatory Network and Indicates Poor Outcome in Colorectal Cancer.
In: Clinical cancer research, Bd. 24, Nr. 8: S. 1974-1986
Blaj, Cristina; Bringmann, Agnes; Schmidt, Eva Marina; Urbischek, Manuela; Lamprecht, Sebastian; Fröhlich, Thomas; Arnold, Georg J.; Krebs, Stefan; Blum, Helmut; Hermeking, Heiko; Jung, Andreas; Kirchner, Thomas und Horst, David
(2017):
ADNP Is a Therapeutically Inducible Repressor of WNT Signaling in Colorectal Cancer.
In: Clinical Cancer Research, Bd. 23, Nr. 11: S. 2769-2780
Blaj, Cristina; Schmidt, Eva Marina; Lamprecht, Sebastian; Hermeking, Heiko; Jung, Andreas; Kirchner, Thomas und Horst, David
(2017):
Oncogenic Effects of High MAPK Activity in Colorectal Cancer Mark Progenitor Cells and Persist Irrespective of RAS Mutations.
In: Cancer Research, Bd. 77, Nr. 7: S. 1763-1774
Lamprecht, Sebastian; Schmidt, Eva Marina; Blaj, Cristina; Hermeking, Heiko; Jung, Andreas; Kirchner, Thomas und Horst, David
(2017):
Multicolor lineage tracing reveals clonal architecture and dynamics in colon cancer.
In: Nature Communications, Bd. 8, 1406
[PDF, 4MB]
Li, Huihui; Rokavec, Matjaz; Jiang, Longchang; Horst, David und Hermeking, Heiko
(2017):
Antagonistic Effects of p53 and HIF1A on microRNA-34a Regulation of PPP1R11 and STAT3 and Hypoxia-induced Epithelial to Mesenchymal Transition in Colorectal Cancer Cells.
In: Gastroenterology, Bd. 153, Nr. 2: S. 505-520
Rokavec, Matjaz; Kaller, Markus; Horst, David und Hermeking, Heiko
(2017):
Pan-cancer EMT-signature identifies RBM47 down-regulation during colorectal cancer progression.
In: Scientific Reports, Bd. 7, 4687
[PDF, 6MB]
Jiang, Longchang und Hermeking, Heiko
(2017):
miR-34a and miR-34b/c Suppress Intestinal Tumorigenesis.
In: Cancer Research, Bd. 77, Nr. 10: S. 2746-2758
Rokavec, Matjaz; Horst, David und Hermeking, Heiko
(2017):
Cellular Model of Colon Cancer Progression Reveals Signatures of mRNAs, miRNA, lncRNAs, and Epigenetic Modifications Associated with Metastasis.
In: Cancer Research, Bd. 77, Nr. 8: S. 1854-1867
Rokavec, Matjaz; Öner, Meryem Gülfem und Hermeking, Heiko
(2016):
lnflammation-induced epigenetic switches in cancer.
In: Cellular and Molecular Life Sciences, Bd. 73, Nr. 1: S. 23-39
Ma-Lauer, Yue; Carbajo-Lozoya, Javier; Hein, Marco Y.; Müller, Marcel A.; Deng, Wen; Lei, Jian; Meyer, Benjamin; Kusov, Yuri; Brunn, Brigitte von; Bairad, Dev Raj; Hünten, Sabine; Drosten, Christian; Hermeking, Heiko; Leonhardt, Heinrich; Mann, Matthias; Hilgenfeld, Rolf und Brunn, Albrecht von
(2016):
p53 down-regulates SARS coronavirus replication and is targeted by the SARS-unique domain and PLpro via E3 ubiquitin ligase RCHY1.
In: Proceedings of the National Academy of Sciences of the United States of America, Bd. 113, Nr. 35, E5192-E5201
Winter, Markus; Lodygin, Dmitri; Verdoodt, Berlinda und Hermeking, Heiko
(2016):
Deletion of 14-3-3 sigma sensitizes mice to DMBA/TPA-induced papillomatosis.
In: Oncotarget, Bd. 7, Nr. 30: S. 46862-46870
Knösel, Thomas; Altendorf-Hofmann, Annelore; Lindner, Lars H.; Issels, Rolf; Hermeking, Heiko; Schuebbe, Gesa; Gibis, Sebastian; Siemens, Helge; Kampmann, Eric und Kirchner, Thomas
(2014):
Loss of p16(INK4a) is associated with reduced patient survival in soft tissue tumours, and indicates a senescence barrier.
In: Journal of clinical pathology, Bd. 67, Nr. 7: S. 592-598
[PDF, 1MB]
Cheng, Chieh-Yang; Hwang, Chang-Il; Corney, David C.; Flesken-Nikitin, Andrea; Jiang, Longchang; Oener, Guelfem Meryem; Munroe, Robert J.; Schimenti, John C.; Hermeking, Heiko und Nikitin, Alexander Yu.
(2014):
miR-34 Cooperates with p53 in Suppression of Prostate Cancer by Joint Regulation of Stem Cell Compartment.
In: Cell Reports, Bd. 6, Nr. 6: S. 1000-1007
[PDF, 3MB]
Cernat, Laura; Blaj, Cristina; Jackstadt, Rene; Brandl, Lydia; Engel, Jutta; Hermeking, Heiko; Jung, Andreas; Kirchner, Thomas und Horst, David
(2014):
Colorectal Cancers Mimic Structural Organization of Normal Colonic Crypts.
In: PLOS ONE 9(8), e104284 [PDF, 24MB]
In: PLOS ONE 9(8), e104284 [PDF, 24MB]
Kriegl, Lydia; Jung, Andreas; Horst, David; Rizzani, Antonia; Jackstadt, Rene; Hermeking, Heiko; Gallmeier, Eike; Gerbes, Alexander L.; Kirchner, Thomas; Göke, Burkhard und De Toni, Enrico N.
(2012):
Microsatellite instability, KRAS mutations and cellular distribution of TRAIL-receptors in early stage colorectal cancer.
In: PLOS ONE 7(12), e51654 [PDF, 646kB]
In: PLOS ONE 7(12), e51654 [PDF, 646kB]
Wolf, Dieter A.; Herzinger, Thomas; Hermeking, Heiko; Blasschke, Dorothea und Hörz, Wolfram
(1993):
Transcriptional and posttranscriptional regulation of human androgen receptor expression by androgen.
In: Molecular Endocrinology, Bd. 7, Nr. 7: S. 924-936
[PDF, 2MB]
Buchbeitrag
Kaller, Markus; Hünten, Sabine; Siemens, Helge und Hermeking, Heiko
(2022):
Analysis of the p53/microRNA Network in Cancer.
In: Schmitz, Ulf; Wolkenhauer, Olaf und Vera-González, Julio (Hrsg.):
Systems Biology of MicroRNAs in Cancer. Advances in Experimental Medicine and Biology, Bd. 1385. Cham: Springer. S. 187-228
Jackstadt, Rene; Kaller, Markus; Menssen, Antje und Hermeking, Heiko
(2021):
Genome-Wide Analysis of c-MYC-Regulated mRNAs and miRNAs and c-MYC DNA-Binding by Next-Generation Sequencing.
In: Soucek, Laura und Whitfield, Jonathan (Hrsg.):
The Myc Gene. Methods in Molecular Biology, Bd. 2318. S. 119-160
Kaller, Markus und Hermeking, Heiko
(2016):
Interplay Between Transcription Factors and MicroRNAs Regulating Epithelial-Mesenchymal Transitions in Colorectal Cancer.
In: Slaby, Ondrej und Calin, George A. (Hrsg.):
Non-coding RNAs in Colorectal Cancer. Advances in Experimental Medicine and Biology, Bd. 937. Cham: Springer. S. 71-92