Neutrophils and extracellular traps in crystal-associated diseases

Ma, Qiuyue und Steiger, Stefanie (2024): Neutrophils and extracellular traps in crystal-associated diseases. In: Trends in Molecular Medicine

Abstract

Crystalline material can cause a multitude of acute and chronic inflammatory diseases, such as gouty arthritis, silicosis, kidney disease, and atherosclerosis. Crystals of various types are thought to cause similar inflammatory responses, including the release of proinflammatory mediators and formation of neutrophil extracellular traps (NETs), processes that further promote necroinflammation and tissue damage. It has become apparent that the intensity of inflammation and the related mechanisms of NET formation and neutrophil death in crystalassociated diseases can vary depending on the crystal type, amount, and site of deposition. This review details new mechanistic insights into crystal biology, highlights the differential effects of various crystals on neutrophils and extracellular trap (ET) formation, and discusses treatment strategies and potential future approaches for crystal-associated disorders

• Item Type: Journal article
• Faculties: Medicine > Medical Center of the University of Munich > Medical Clinic and Outpatient Clinic IV (Endocrinology, nephrology, other sections)
• Subjects: 600 Technology > 610 Medicine and health
• ISSN: 14714914
• Language: English