The Role of Interleukin‐8 in the Estimation of Responsiveness to Steps 1 and 2 of Periodontal Therapy

Bumm, Caspar Victor ; Schwendicke, Falk; Heck, Katrin; Frasheri, Iris; Summer, Burkhard; Ern, Christina; Heym, Richard; Werner, Nils und Folwaczny, Matthias (2024): The Role of Interleukin‐8 in the Estimation of Responsiveness to Steps 1 and 2 of Periodontal Therapy. In: Journal of Clinical Periodontology, Vol. 51, No. 11: pp. 1433-1442

Abstract

Objective To investigate the association between interleukin-8 (IL-8) levels in gingival crevicular fluid (GCF) and total oral fluid (TOF) and the responsiveness to steps 1 and 2 of periodontal therapy.

Materials and Methods One-hundred and fifty-nine patients affected by periodontitis received steps 1 and 2 of periodontal therapy. At baseline, TOF and GCF samples were collected and analysed for IL-8 (Il-8TOF/IL-8GCF) using flow cytometry. Therapy outcomes were relative proportions of residual periodontal pockets (PPD%), pocket closure (PC) rates and pocket probing depth (PPD) reductions; these were associated with IL-8TOF/IL-8GCF.

Results High IL-8TOF was significantly associated with higher residual PPD% (p = 0.044) and lower PPD reduction compared to low IL-8TOF (high 0.79 ± 1.20 mm vs. low 1.20 ± 1.20 mm, p < 0.001) in non-smokers, while in smokers high IL-8GCF was related to lower PPD reduction (high 0.62 ± 1.22 mm vs. low 0.84 ± 1.12 mm, p = 0.009). Furthermore, high baseline IL-8TOF was significantly associated with poorer PC rates compared to medium and low concentrations in both non-smokers (high 41% vs. medium 55% vs. low 58%, p < 0.001) and smokers (high 34% vs. medium 44% vs. low 46%, p < 0.001).

Conclusion High IL-8 concentrations at baseline had a significant impact on residual PPD%, PC rates and PPD reduction. The findings suggest that, especially in non-smokers, baseline IL-8 levels collected from the TOF could serve as a component in the estimation of responsiveness to steps 1 and 2 of periodontal therapy.

• Item Type: Journal article
• Faculties: Medicine > Medical Center of the University of Munich > Polyclinic for Dental Preservation and Periodontology
• Subjects: 600 Technology > 610 Medicine and health
• ISSN: 0303-6979
• Language: English