ORCID: https://orcid.org/0000-0002-3192-1019; Pütz, Benno; Kielkowski, Pavel
ORCID: https://orcid.org/0000-0003-4910-6263; Cernilogar, Filippo M.; Maccarrone, Giuseppina; Giaimo, Rossella Di
ORCID: https://orcid.org/0000-0003-3604-3697 und Cappello, Silvia
(2024):
Extracellular vesicle-mediated trafficking of molecular cues during human brain development.
In: Cell Reports, Vol. 43, No. 10, 114755
[PDF, 6MB]

Abstract
Cellular crosstalk is an essential process influenced by numerous factors, including secreted vesicles that transfer nucleic acids, lipids, and proteins between cells. Extracellular vesicles (EVs) have been the center of many studies focusing on neurodegenerative disorders, but whether EVs display cell-type-specific features for cellular crosstalk during neurodevelopment is unknown. Here, using human-induced pluripotent stem cell-derived cerebral organoids, neural progenitors, neurons, and astrocytes, we identify heterogeneity in EV protein content and dynamics in a cell-type-specific and time-dependent manner. Our results support the trafficking of key molecules via EVs in neurodevelopment, such as the transcription factor YAP1, and their localization to differing cell compartments depending on the EV recipient cell type. This study sheds new light on the biology of EVs during human brain development.
Item Type: | Journal article |
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Faculties: | Medicine Chemistry and Pharmacy > Department of Chemistry Medicine > Institute of Physiology Medicine > Adolf Butenandt Institute Medicine > Munich Cluster for Systems Neurology (SyNergy) Medicine > Medical Center of the University of Munich > Medical Clinic and Outpatient Clinic I (Cardiology) |
Subjects: | 600 Technology > 610 Medicine and health |
URN: | urn:nbn:de:bvb:19-epub-123166-0 |
ISSN: | 2211-1247 |
Language: | English |
Item ID: | 123166 |
Date Deposited: | 17. Dec 2024 14:09 |
Last Modified: | 17. Dec 2024 14:09 |
DFG: | Gefördert durch die Deutsche Forschungsgemeinschaft (DFG) - 390857198 |