Longitudinal associations between exercise and biomarkers in autosomal dominant Alzheimer's disease

Sewell, Kelsey R. ; Doecke, James D.; Xiong, Chengjie; Benzinger, Tammie; Masters, Colin L.; Laske, Christoph; Jucker, Mathias; Lopera, Francisco; Gordon, Brian A.; Llibre‐Guerra, Jorge; Levin, Johannes ; Huey, Edward D.; Hassenstab, Jason; Schofield, Peter R.; Day, Gregory S.; Fox, Nick C.; Chhatwal, Jasmeer; Ibanez, Laura; Roh, Jee Hoon; Perrin, Richard; Lee, Jae‐Hong; Allegri, Ricardo F.; Supnet‐Bell, Charlene; Berman, Sarah B.; Daniels, Alisha; Noble, James; Martins, Ralph N.; Rainey‐Smith, Stephanie; Peiffer, Jeremiah; Gardener, Samantha L.; Bateman, Randall J.; Morris, John C.; McDade, Eric; Erickson, Kirk I.; Sohrabi, Hamid R. und Brown, Belinda M. (2024): Longitudinal associations between exercise and biomarkers in autosomal dominant Alzheimer's disease. In: Alzheimer's & Dementia, Vol. 20, No. 11: pp. 7923-7939

Abstract

Introduction : We investigated longitudinal associations between self-reported exercise and Alzheimer's disease (AD)-related biomarkers in individuals with autosomal dominant AD (ADAD) mutations. Methods : Participants were 308 ADAD mutation carriers aged 39.7 ± 10.8 years from the Dominantly Inherited Alzheimer's Network. Weekly exercise volume was measured via questionnaire and associations with brain volume (magnetic resonance imaging), cerebrospinal fluid biomarkers, and brain amyloid beta (Aβ) measured by positron emission tomography were investigated. Results : Greater volume of weekly exercise at baseline was associated with slower accumulation of brain Aβ at preclinical disease stages β = –0.16 [–0.23 to –0.08], and a slower decline in multiple brain regions including hippocampal volume β = 0.06 [0.03 to 0.08]. Discussion : Exercise is associated with more favorable profiles of AD-related biomarkers in individuals with ADAD mutations. Exercise may have therapeutic potential for delaying the onset of AD; however, randomized controlled trials are vital to determine a causal relationship before a clinical recommendation of exercise is implemented.

• Item Type: Journal article
• Faculties: Medicine > Munich Cluster for Systems Neurology (SyNergy); Medicine > Institute for Stroke and Dementia Research (ISD); Medicine > Medical Center of the University of Munich > Neurological Clinic and Polyclinic with Friedrich Baur Institute
• Subjects: 600 Technology > 610 Medicine and health
• ISSN: 1552-5260
• Language: English
• DFG: Gefördert durch die Deutsche Forschungsgemeinschaft (DFG) - 390857198