The oncological role of resection in newly diagnosed diffuse adult-type glioma defined by the WHO 2021 classification

Karschnia, Philipp ; Gerritsen, Jasper K. W.; Teske, Nico; Cahill, Daniel P.; Jakola, Asgeir S.; Bent, Martin van den; Weller, Michael; Schnell, Oliver; Vik-Mo, Einar O.; Thon, Niklas; Vincent, Arnaud J. P. E.; Kim, Michelle M.; Reifenberger, Guido; Chang, Susan M.; Hervey-Jumper, Shawn L.; Berger, Mitchel S. und Tonn, Joerg-Christian (2024): The oncological role of resection in newly diagnosed diffuse adult-type glioma defined by the WHO 2021 classification. A Review by the RANO resect group. In: Lancet Oncology, Vol. 25, No. 9, e404-e419

Abstract

Glioma resection is associated with prolonged survival, but neuro-oncological trials have frequently refrained from quantifying the extent of resection. The Response Assessment in Neuro-Oncology (RANO) resect group is an international, multidisciplinary group that aims to standardise research practice by delineating the oncological role of surgery in diffuse adult-type gliomas as defined per WHO 2021 classification. Favourable survival effects of more extensive resection unfold over months to decades depending on the molecular tumour profile. In tumours with a more aggressive natural history, supramaximal resection might correlate with additional survival benefit. Weighing the expected survival benefits of resection as dictated by molecular tumour profiles against clinical factors, including the introduction of neurological deficits, we propose an algorithm to estimate the oncological effects of surgery for newly diagnosed gliomas. The algorithm serves to select patients who might benefit most from extensive resection and to emphasise the relevance of quantifying the extent of resection in clinical trials.

• Item Type: Journal article
• Faculties: Medicine > Medical Center of the University of Munich > Neurosurgical Clinic and Polyclinic
• Subjects: 600 Technology > 610 Medicine and health
• ISSN: 14702045
• Annotation: This article is available under the Creative Commons CC-BY-NC license and permits non-commercial use, distribution and reproduction in any medium, provided the original work is properly cited (compare official publisher website)
• Language: English