Correlation of early-phase β-amyloid positron-emission-tomography and neuropsychological testing in patients with Alzheimer’s disease

Völter, Friederike ; Eckenweber, Sebastian; Scheifele, Maximilian; Eckenweber, Florian; Hirsch, Fabian; Franzmeier, Nicolai ; Kreuzer, Annika; Griessl, Maria; Steward, Anna ; Janowitz, Daniel ; Palleis, Carla ; Bernhardt, Alexander ; Vöglein, Jonathan ; Stockbauer, Anna; Rauchmann, Boris-Stephan ; Schöberl, Florian; Wlasich, Elisabeth; Buerger, Katharina ; Wagemann, Olivia; Perneczky, Robert ; Weidinger, Endy; Höglinger, Günter ; Levin, Johannes ; Brendel, Matthias und Schönecker, Sonja (2025): Correlation of early-phase β-amyloid positron-emission-tomography and neuropsychological testing in patients with Alzheimer’s disease. In: European Journal of Nuclear Medicine and Molecular Imaging, Vol. 52: pp. 2918-2928

Abstract

Purpose : Clinical staging in individuals with Alzheimer’s disease (AD) typically relies on neuropsychological testing. Recognizing the imperative for an objective measure of clinical AD staging, regional perfusion in early-phase β-amyloid-PET may aid as a cost-efficient index for the assessment of neurodegeneration severity in patients with Alzheimer’s disease.

Methods : Regional perfusion deficits in early-phase β-amyloid-PET as well as neuropsychological testing (max. 90 days delay) were evaluated in 82 patients with biologically defined AD according to the ATN classification. In reference to the Braak staging system patients were classified into the groups stage0, stageI−II+, stageI−IV+, stageI−VI+, and stageatypical+ according to regional perfusion deficits in regions of interest (ROIs) published by the Alzheimer’s Disease Neuroimaging Initiative. Multiple regression analysis controlling for age, gender, and education was used to evaluate the association of regional z-scores on perfusion-phase PET with clinical scores for all patients and with annual decline of cognitive performance in 23 patients with follow-up data.

Results : Patients classified as stage0 and stageI−II+ demonstrated significantly superior neuropsychological performance compared to those classified as stageI−IV+ and stageI−VI+. Lower cognitive performance was associated with decreased perfusion in early-phase β-amyloid-PET globally and regionally, with the most pronounced association identified in the left temporal lobe. Mean z-scores on early-phase PET in temporal and parietal regions offered a robust prediction of future annual decline in MMSE and sum scores of the CERAD-Plus (Consortium to Establish a Registry for Alzheimer’s Disease) test battery.

Conclusion : Regional and global perfusion deficits in early-phase β-amyloid-PET can serve as an objective index of neurodegeneration severity and may act as prognostic markers of future cognitive decline in AD.

• Item Type: Journal article
• Faculties: Medicine > Munich Cluster for Systems Neurology (SyNergy); Medicine > Institute for Stroke and Dementia Research (ISD); Medicine > Medical Center of the University of Munich; Medicine > Medical Center of the University of Munich > Medical Clinic and Outpatient Clinic IV (Endocrinology, nephrology, other sections); Medicine > Medical Center of the University of Munich > Neurological Clinic and Polyclinic with Friedrich Baur Institute; Medicine > Medical Center of the University of Munich > Clinic and Polyclinic for Nuclear Medicine
• Subjects: 600 Technology > 610 Medicine and health
• ISSN: 1619-7070
• Language: English
• DFG: Gefördert durch die Deutsche Forschungsgemeinschaft (DFG) - 390857198