Novel approaches to CAR T cell target identification in acute myeloid leukemia

Hoffmann, Gordon Victor ; Gottschlich, Adrian ; Subklewe, Marion und Kobold, Sebastian (June 2025): Novel approaches to CAR T cell target identification in acute myeloid leukemia. In: Current Opinion in Pharmacology, Vol. 82, 102524

Abstract

Identifying safe and effective CAR T cell targets in acute myeloid leukemia (AML) is challenging due to the disease’s complexity and overlap with normal hematopoiesis. This review highlights advances in target discovery for AML, emphasizing innovative approaches. Structural surfaceomics identifies tumor-specific protein conformations, while AI-driven single-cell RNA sequencing integrates multi-source data to pinpoint optimal targets. Refined cell surface capture technology maps the AML surfaceome without relying on predefined antibodies. These strategies enhance CAR T cell specificity and minimize off-tumor effects, offering promising pathways for safer and more effective AML treatments and broader cancer therapies.

• Item Type: Journal article
• EU Funded Grant Agreement Number: 955575
• Faculties: Medicine > Walther Straub Institute of Pharmacology and toxicology; Medicine > Medical Center of the University of Munich > Medical Clinic and Outpatient Clinic III (Oncology)
• Subjects: 600 Technology > 610 Medicine and health
• ISSN: 14714892
• Language: English
• DFG: Gefördert durch die Deutsche Forschungsgemeinschaft (DFG) - 452881907