ORCID: https://orcid.org/0009-0005-7117-0335; Gerhards, Ramona ORCID: https://orcid.org/0000-0002-5398-3632; Boldrini, Vinicius; Wichmann, Christian; Peters, Anneli ORCID: https://orcid.org/0000-0002-8259-2219 und Meinl, Edgar ORCID: https://orcid.org/0000-0002-2570-6785
(24. February 2025):
BTK‐Inhibition Enhances TLR‐7‐Mediated Interferon‐Alpha Production in pDCs by Blocking the Inhibitory BDCA‐2 Pathway.
In: European Journal of Immunology, Vol. 55, No. 2, e202450985
[PDF, 543kB]
Abstract
In pDCs, BTK-inhibition (BTKi) blocks the IFN-α production via TLR-9, but not via TLR-7. Upon TLR-7 stimulation, BTKi enhances the production of IFN-α by blocking the inhibitory BDCA-2 pathway. This might explain partially the failure of BTKi in SLE and is of interest for BTKi trials in multiple sclerosis.
| Item Type: | Journal article |
|---|---|
| Faculties: | Medicine > Medical Center of the University of Munich > Neurosurgical Clinic and Polyclinic |
| Subjects: | 600 Technology > 610 Medicine and health |
| URN: | urn:nbn:de:bvb:19-epub-128826-3 |
| ISSN: | 0014-2980 |
| Language: | English |
| Item ID: | 128826 |
| Date Deposited: | 22. Oct 2025 14:32 |
| Last Modified: | 22. Oct 2025 14:32 |
| DFG: | Gefördert durch die Deutsche Forschungsgemeinschaft (DFG) - 213904703 |
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