ORCID: https://orcid.org/0009-0009-4722-9914; Klietz, Martin ORCID: https://orcid.org/0000-0002-3054-9905; Greten, Stephan; Kopp, Bruno; Berding, Georg ORCID: https://orcid.org/0000-0001-5592-8373; Brendel, Matthias ORCID: https://orcid.org/0000-0002-9247-2843; Wilkens, Ida ORCID: https://orcid.org/0009-0006-0270-0029; Katzdobler, Sabrina ORCID: https://orcid.org/0000-0002-3512-5984; Levin, Johannes ORCID: https://orcid.org/0000-0001-5092-4306; Danek, Adrian ORCID: https://orcid.org/0000-0001-8857-5383; Rogozinski, Sophia; Höglinger, Günter U. ORCID: https://orcid.org/0000-0001-7587-6187; Pötter-Nerger, Monika ORCID: https://orcid.org/0000-0001-7680-2147; Buhmann, Carsten ORCID: https://orcid.org/0000-0001-8540-3789; Buchert, Ralph ORCID: https://orcid.org/0000-0002-0945-0724 und Wegner, Florian
(2025):
Associations between neuropsychological profile and regional brain FDG uptake in progressive supranuclear palsy.
In: Journal of Parkinson’s Disease, Vol. 15, No. 4: pp. 904-912
[PDF, 3MB]
Abstract
Background
Progressive supranuclear palsy (PSP) is a rare neurodegenerative movement disorder clinically characterized by falls, axial rigidity, vertical supranuclear gaze palsy, bradykinesia, and cognitive decline. There is a relative lack of studies on the functional neuroimaging correlates of cognitive impairment in PSP.
Objective
This study investigated the relationship between regional cerebral glucose metabolism as assessed by static 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) with global scaling and the profile of cognitive performance according to the Consortium to Establish a Registry for Alzheimer's Disease (CERAD) test battery in a sample of PSP patients representative of clinical practice.
Methods
22 PSP patients from three tertiary movement disorder centers with CERAD testing and FDG-PET in close proximity were included retrospectively. Neuropsychological test performance was assessed for correlation with FDG uptake on a voxel-by-voxel basis with cluster-level correction for multiple testing, separately for each subtest.
Results
In comparison to matched healthy controls, PSP patients showed reduced FDG uptake in the left inferior frontal gyrus and right angular gyrus. Reduced overall cognitive performance according to Montreal Cognitive Assessment was associated with reduced FDG uptake in the right frontal eye field. Word list learning correlated with FDG uptake in the left frontal eye field, while language fluency was linked to FDG uptake in the bilateral premotor and supplementary motor areas.
Conclusions
Reduction of FDG uptake in PSP primarily affects frontal brain regions and is linked to the performance in specific cognitive domains. These findings may have implications for the interpretation of FDG-PET to support the etiological diagnosis of PSP.
| Item Type: | Journal article |
|---|---|
| Faculties: | Medicine > Munich Cluster for Systems Neurology (SyNergy) Medicine > Medical Center of the University of Munich > Neurological Clinic and Polyclinic with Friedrich Baur Institute Medicine > Medical Center of the University of Munich > Clinic and Polyclinic for Nuclear Medicine |
| Subjects: | 600 Technology > 610 Medicine and health |
| URN: | urn:nbn:de:bvb:19-epub-129516-3 |
| ISSN: | 1877-7171 |
| Language: | English |
| Item ID: | 129516 |
| Date Deposited: | 17. Nov 2025 14:40 |
| Last Modified: | 17. Nov 2025 14:40 |
| DFG: | Gefördert durch die Deutsche Forschungsgemeinschaft (DFG) - 390857198 |
Actions (login required)
- View Item
