ORCID: https://orcid.org/0000-0003-2449-5530; Sondermann, Verena; Schniewind, Iñaki; Hähnel, Tom; Dinter, Elisabeth; Kleineidam, Luca ORCID: https://orcid.org/0009-0006-3309-6856; Stark, Melina ORCID: https://orcid.org/0009-0005-3812-023X; Schmid, Matthias; Sodenkamp, Sebastian; Laske, Christoph ORCID: https://orcid.org/0009-0009-3434-936X; Spruth, Eike; Priller, Josef ORCID: https://orcid.org/0000-0001-7596-0979; Janowitz, Daniel ORCID: https://orcid.org/0009-0003-4090-547X; Bürger, Katharina; Kilimann, Ingo ORCID: https://orcid.org/0000-0002-3269-4452; Teipel, Stefan ORCID: https://orcid.org/0000-0002-3586-3194; Storch, Alexander; Hansen, Niels ORCID: https://orcid.org/0000-0001-5785-9594; Wiltfang, Jens ORCID: https://orcid.org/0000-0003-1492-5330; Glanz, Wenzel ORCID: https://orcid.org/0000-0002-5865-4176; Düzel, Emrah ORCID: https://orcid.org/0000-0002-0139-5388; Preis, Lukas ORCID: https://orcid.org/0000-0001-7601-6410; Peters, Oliver ORCID: https://orcid.org/0000-0003-0568-2998; Hellmann‐Regen, Julian; Wagner, Michael ORCID: https://orcid.org/0000-0003-2589-6440; Bernhardt, Alexander ORCID: https://orcid.org/0000-0002-2572-5062; Levin, Johannes ORCID: https://orcid.org/0000-0001-5092-4306; Petzold, Gabor C. ORCID: https://orcid.org/0000-0002-0145-8641; Kronmüller, Marie; Gamez, Anna; Spottke, Annika ORCID: https://orcid.org/0000-0001-9854-2972; Brosseron, Frederic ORCID: https://orcid.org/0000-0003-3137-7516; Rostamzadeh, Ayda ORCID: https://orcid.org/0000-0001-5189-134X; Jessen, Frank ORCID: https://orcid.org/0000-0003-1067-2102; Hermann, Andreas; Fliessbach, Klaus ORCID: https://orcid.org/0000-0002-0183-7510; Schneider, Anja ORCID: https://orcid.org/0000-0001-9540-8700 und Falkenburger, Björn H. ORCID: https://orcid.org/0000-0002-2387-526X
(2026):
Alpha‐synuclein quantitative seed amplification assay predicts conversion to dementia.
In: Alzheimer's & Dementia, Vol. 22, No. 1, e71167
[PDF, 598kB]
Abstract
INTRODUCTION:
The alpha-synuclein seed amplification assay (SAA) has shown excellent performance in the detection of Lewy body pathology in cerebrospinal fluid (CSF). Lewy body pathology is prognostically relevant in patients at risk for dementia. Current assays only provide binary results, so there is a need to quantify the extent of pathology in living patients.
METHODS:
In addition to the “standard” SAA, we developed a quantitative SAA (qnSAA) and measured 432 CSF samples (216 baseline–follow-up pairs).
RESULTS:
qnSAA results correlated with cognitive performance. Seventy-five percent of participants with fast qnSAA kinetics converted to dementia in the observed interval. Overall, participants with fast qnSAA kinetics accounted for 27.3% of dementia converters in the entire cohort.
DISCUSSION:
Findings demonstrate promising properties of qnSAA measurements in a cohort of patients at risk for dementia. qnSAA results showed improved prognostic relevance and have potential to measure target engagement of therapies against Lewy body pathology.
| Item Type: | Journal article |
|---|---|
| Faculties: | Medicine > Munich Cluster for Systems Neurology (SyNergy) Medicine > Institute for Stroke and Dementia Research (ISD) Medicine > Medical Center of the University of Munich > Neurological Clinic and Polyclinic with Friedrich Baur Institute |
| Subjects: | 600 Technology > 610 Medicine and health |
| URN: | urn:nbn:de:bvb:19-epub-132192-8 |
| ISSN: | 1552-5260 |
| Language: | English |
| Item ID: | 132192 |
| Date Deposited: | 16. Feb 2026 09:55 |
| Last Modified: | 16. Feb 2026 09:55 |
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