ORCID: https://orcid.org/0000-0002-1340-638X; Llibre-Guerra, Jorge J. ORCID: https://orcid.org/0000-0002-2137-7750; O'Connor, Antoinette und Levin, Johannes ORCID: https://orcid.org/0000-0001-5092-4306
(2026):
Lessons from the Colombian kindred: rethinking Alzheimer's prevention.
In: Lancet Neurology, Vol. 25, No. 2: pp. 117-119
Abstract
In The Lancet Neurology, Pierre N Tariot and colleagues present the Alzheimer's Prevention Initiative (API) Colombia Trial, a landmark public–private partnership, evaluating crenezumab in autosomal-dominant Alzheimer's disease (ADAD). The API ADAD Colombia Trial enrolled 252 members of the world's largest kindred in Medellín, Colombia, all carrying the PSEN1 Glu280Ala mutation, a population whose well characterised natural history, defined through decades of work by the late Francisco Lopera and colleagues, made it uniquely suited for a preventive intervention.
| Item Type: | Journal article |
|---|---|
| Faculties: | Medicine > Munich Cluster for Systems Neurology (SyNergy) Medicine > Medical Center of the University of Munich > Neurological Clinic and Polyclinic with Friedrich Baur Institute |
| Subjects: | 600 Technology > 610 Medicine and health |
| ISSN: | 1474-4422 |
| Language: | English |
| Item ID: | 132236 |
| Date Deposited: | 16. Feb 2026 15:05 |
| Last Modified: | 16. Feb 2026 15:05 |
| DFG: | Gefördert durch die Deutsche Forschungsgemeinschaft (DFG) - 390857198 |
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