ORCID: https://orcid.org/0000-0003-1554-7765; Kusche‐Palenga, Julia; Palleis, Carla ORCID: https://orcid.org/0000-0002-4331-8145; Neubauer, Antonia; Frontzkowski, Lukas ORCID: https://orcid.org/0000-0001-9321-956X; Jäck, Alexander; Kling, Agnes; Bauer, Theresa; Eyob, Hannah; Probst, Katharina; Roemer‐Cassiano, Sebastian N.; Bernhardt, Alexander M. ORCID: https://orcid.org/0000-0002-2572-5062; Katzdobler, Sabrina ORCID: https://orcid.org/0000-0002-3512-5984; Marth, Lena ORCID: https://orcid.org/0009-0004-9980-9981; Zaganjori, Mirlind ORCID: https://orcid.org/0009-0000-5740-4549; Hopfner, Franziska ORCID: https://orcid.org/0000-0001-6524-0281; Zwergal, Andreas ORCID: https://orcid.org/0000-0002-3839-8398; Häckert, Jan; Rullmann, Michael ORCID: https://orcid.org/0000-0002-2683-9432; Sabri, Osama ORCID: https://orcid.org/0000-0002-6425-3504; Barthel, Henryk; Stöcklein, Sophia ORCID: https://orcid.org/0000-0003-0325-4674; Werner, Rudolf A.; Simons, Mikael ORCID: https://orcid.org/0000-0001-5329-192X; Levin, Johannes ORCID: https://orcid.org/0000-0001-5092-4306; Herms, Jochen; Franzmeier, Nicolai ORCID: https://orcid.org/0000-0001-9736-2283; Höglinger, Günter U. ORCID: https://orcid.org/0000-0001-7587-6187 und Brendel, Matthias ORCID: https://orcid.org/0000-0002-9247-2843
(2026):
Longitudinal monitoring of tau aggregation in progressive supranuclear palsy with [18F]PI‐2620 PET.
In: Alzheimer's & Dementia, Vol. 22, No. 2, e71195
[PDF, 6MB]
Abstract
INTRODUCTION: Progressive supranuclear palsy (PSP), a 4-repeat tauopathy, can be visualized using [18F]PI-2620 tau positron emission tomography (PET). However, the value of sequential [18F]PI-2620 imaging for tracking tau accumulation during the disease course has not yet been investigated.
METHODS: Twenty-three PSP patients underwent two [18F]PI-2620 PET scans (interval: 21.4 ± 4.3 months) and were compared to cross-sectional data from 25 healthy controls. Regional volume of distribution ratio values were analyzed for longitudinal tau changes, clinical correlations, and network-based propagation. Post mortem analyses examined neuronal density and AT8 tau pathology.
RESULTS: Subcortical tau PET signals increased, strongest in the globus pallidus internus (P < 0.0001). Patients with low baseline tau showed the largest increases. Despite clinical worsening (Progressive Supranuclear Palsy Rating Scale +48%), tau PET change did not correlate with symptom progression. Tau accumulation followed functional connectivity (R = 0.34, P < 0.0001). Post mortem data linked elevated tau PET to higher AT8 burden despite neuronal loss.
DISCUSSION: [18F]PI-2620 PET enables monitoring of tau progression in PSP, indicating network-based tau propagation with saturation in advanced stages.
| Item Type: | Journal article |
|---|---|
| Faculties: | Medicine > Institute of Neuropathology Medicine > Munich Cluster for Systems Neurology (SyNergy) Medicine > Institute for Stroke and Dementia Research (ISD) Medicine > Medical Center of the University of Munich > Neurological Clinic and Polyclinic with Friedrich Baur Institute Medicine > Medical Center of the University of Munich > Clinic and Polyclinic for Nuclear Medicine Medicine > Medical Center of the University of Munich > Clinic and Polyclinic for Radiology Medicine > Medical Center of the University of Munich > German Center for Vertigo and Balance Disorders |
| Subjects: | 600 Technology > 610 Medicine and health |
| URN: | urn:nbn:de:bvb:19-epub-133148-6 |
| ISSN: | 1552-5260 |
| Language: | English |
| Item ID: | 133148 |
| Date Deposited: | 16. Mar 2026 15:54 |
| Last Modified: | 16. Mar 2026 15:54 |
| DFG: | Gefördert durch die Deutsche Forschungsgemeinschaft (DFG) - 390857198 |
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