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Heckmann, S.M.; Hujoel, P.; Habiger, S.; Friess, Wolfgang; Wichmann, M.; Heckmann, J.G. and Hummel, T. (2005): Zinc Gluconate in the Treatment of Dysgeusia—a Randomized Clinical Trial. In: Journal of Dental Research, Vol. 84, No. 1: pp. 35-38 [PDF, 401kB]


In the treatment of dysgeusia, the use of zinc has been frequently tried, with equivocal results. The aim of the present randomized clinical trial, which involved a sufficiently large sample, was therefore to determine the efficacy of zinc treatment. Fifty patients with idiopathic dysgeusia were carefully selected. Zinc gluconate (140 mg/day; n = 26) or placebo (lactose; n = 24) was randomly assigned to the patients. The patients on zinc improved in terms of gustatory function (p < 0.001) and rated the dysgeusia as being less severe (p < 0.05). Similarly, signs of depression in the zinc group were less severe (Beck Depression Inventory, p < 0.05; mood scale, p < 0.05). With the exception of the salivary calcium level, which was higher in the zinc patients (p < 0.05), no other significant group differences were found. In conclusion, zinc appears to improve general gustatory function and, consequently, general mood scores in dysgeusia patients.

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