Naeem, Haroon; Küffner, Robert; Zimmer, Ralf
MIRTFnet: analysis of miRNA regulated transcription factors.
In: PLOS ONE
Several expression datasets of miRNA transfection experiments are available to analyze the regulatory mechanisms downstream of miRNA effects. The miRNA induced regulatory effects can be propagated via transcription factors (TFs). We propose the method MIRTFnet to identify miRNA controlled TFs as active regulators if their downstream target genes are differentially expressed.