van de Pol, L. A.; Verhey, F.; Frisoni, G. B.; Tsolaki, M.; Papapostolou, P.; Nobili, F.; Wahlund, L-O.; Minthon, L,; Frölich, L.; Hampel, Harald; Soininen, H.; Knol, D. L.; Barkhof, F.; Scheltens, P.; Visser, P. J.
White matter hyperintensities and medial temporal lobe atrophy in clinical subtypes of mild cognitive impairment: the DESCRIPA study.
In: Journal of Neurology, Neurosurgery and Psychiatry, Vol. 80: pp. 1069-1074
Background: Clinical subtypes of mild cognitive impairment
(MCI) may represent different underlying aetiologies.
Methods: This European, multicentre, memory clinic
based study (DESCRIPA) of non-demented subjects
investigated whether MCI subtypes have different brain
correlates on MRI and whether the relation between
subtypes and brain pathology is modified by age. Using
visual rating scales, medial temporal lobe atrophy (MTA)
(0–4) and white matter hyperintensities (WMH) (0–30)
Results: Severity of MTA differed between MCI subtypes
(p,0.001), increasing from a mean of 0.8 (SD 0.7) in
subjective complaints (n=77) to 1.3 (0.8) in nonamnestic
MCI (n=93), and from 1.4 (0.9) in single
domain amnestic MCI (n=70) to 1.7 (0.9) in multiple
domain amnestic MCI (n=89). The association between
MCI subtype and MTA was modified by age and mainly
present in subjects .70 years of age. Severity of WMH
did not differ between MCI subtypes (p=0.21).
However, the combination of MTA and WMH differed
between MCI subtypes (p=0.02)
Conclusion: We conclude that MCI subtypes may have
different brain substrates, especially in older subjects.
Isolated MTA was mainly associated with amnestic MCI
subtypes, suggesting AD as the underlying cause. In nonamnestic
MCI, the relatively higher prevalence of MTA in
combination with WMH may suggest a different