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Holzapfel, Christina; Grallert, Harald; Baumert, Jens; Thorand, Barbara; Döring, Angela; Wichmann, Heinz-Erich; Hauner, Hans; Illig, Thomas; Mielck, Andreas (February 2011): First investigation of two obesity-related loci (TMEM18, FTO) concerning their association with educational level as well as income: the MONICA/KORA study. In: Journal of epidemiology and community health, Vol. 65, No. 2: pp. 174-176




Strong evidence exists for an association between socioeconomic status and body mass index (BMI) as well as between genetic variants and BMI. The association of genetic variants with socioeconomic status has not yet been investigated. The aim of this study was to investigate two obesity-related loci--the transmembrane 18 (TMEM18) and the fat mass and obesity-associated (FTO) gene--for their association with educational level and per capita income, and to test whether the detected genotype-BMI association is mediated by these social factors.