Müller, C. A.; Engler-Blum, G.; Gekeler, V.; Steiert, I.; Weiss, Elisabeth H.; Schmidt, H.
Genetic and serological heterogeneity of the supertypic HLA-B locus specificities Bw4 and Bw6.
In: Immunogenetics, Vol. 30: pp. 200-207
Gene cloning and sequencing of the HLA-B
locus split antigens B38 (B16.1) and B39 (B16.2) allowed
localization of their subtypic as well as their public
specificities HLA-Bw4 or -Bw6 to the c~-helical region of
the c~ 1 domain flanked by the amino acid positions 74-83.
Comparison of their amino acid sequences with those of
other HLA-B-locus alleles established HLA-Bw6 to be
distinguished by Ser at residue 77 and Asn at residue 80.
In contrast, HLA-Bw4 is characterized by at least seven
different patterns of amino acid exchanges at positions 77
and 80-83. Reactivity patterns of Bw4- or Bw6-specific
monoclonal antibodies reveal two alloantigenic epitopes
contributing to the HLA-Bw4 or -Bw6 specificity residing
next to the region of highest diversity of the cr domain.