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Biel, Martin; Altenhofen, Wolfram; Hullin, Roger; Ludwig, Jost; Freichel, Marc; Flockerzi, Veit; Dascal, Nathan; Kaupp, U. Benjamin; Hofmann, Franz (1993): Primary structure and functional expression of a cyclic nucleotidegated channel from rabbit aorta. In: FEBS Letters, Vol. 329, No. 1 - 2: pp. 134-138




Sequences specific for cyclic nucleotide-gated channels (CNG channels) have been amplified by PCR from cDNA of heart, aorta, sinoatrial node, cerebellum, C-cells and kidney. The complete amino acid sequence of a CNG channel from rabbit aorta has been deduced by cloning and sequence analysis of the cDNA. Synthetic RNA derived from this cDNA induces the formation of a functional CNG channel in Xenopus oocytes.