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Johannes Denk, Felix Oberhauser, Johannes Kornhuber, Jens Wiltfang, Klaus Fassbender, Matthias L. Schroeter, Alexander E. Volk, Janine Diehl-Schmid, Johannes Prudlo, Adrian Danek, Bernhard Landwehrmeyer, Martin Lauer, Markus Otto, Holger Jahn, for the FTLDc study group
Specific serum and CSF microRNA profiles distinguish sporadic behavioural variant of frontotemporal dementia compared with Alzheimer patients and cognitively healthy controls
www.plosone.org
www.plosone.org
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(any)Tj
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(entries)Tj
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(in)Tj
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(the)Tj
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(database.)Tj
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(data)Tj
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(\(GLP\))Tj
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(and)Tj
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1 j
1 J
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11.9999 0 0 11.9999 200.0125 561.3732 cm
BT
/F11 1 Tf
1 TL
-0.0033 Tc
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(data)Tj
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(47)Tj
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(serum\))Tj
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(control)Tj
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5.4594 0 Td
(\(FTLDc\),)Tj
3.9572 0 Td
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2.6532 0 Td
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3.7417 0 Td
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1.1736 0 Td
(academic)Tj
3.9685 0 Td
(centers)Tj
3.0727 0 Td
(across)Tj
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([)Tj
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(19)Tj
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(].)Tj
-35.0133 -1.2982 Td
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1.3946 0 Td
(bvFTD)Tj
3.0557 0 Td
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(diagnostic)Tj
4.32 0 Td
(criteria)Tj
3.0727 0 Td
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4.1896 0 Td
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1.0261 0 Td
(Rascovsky)Tj
4.3313 0 Td
(et)Tj
0.9411 0 Td
(al.)Tj
1.1282 0 Td
(\(2011\))Tj
2.8006 0 Td
([)Tj
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(20)Tj
0 g
(].)Tj
-35.1153 -1.2983 Td
(Alzheimer's)Tj
4.9719 0 Td
(disease)Tj
3.016 0 Td
(\(AD\))Tj
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1.7007 0 Td
(diagnosed)Tj
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(according)Tj
4.1896 0 Td
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1.0261 0 Td
(criteria)Tj
3.0728 0 Td
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2.211 0 Td
(the)Tj
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3.6907 0 Td
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(of)Tj
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5.3744 0 Td
(and)Tj
1.7291 0 Td
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6.6727 0 Td
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3.5887 0 Td
(and)Tj
1.7291 0 Td
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2.7949 0 Td
(\(NINCDS\)Alzheimer's)Tj
9.8532 0 Td
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3.2315 0 Td
(and)Tj
-34.9736 -1.2983 Td
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3.1917 0 Td
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4.1499 0 Td
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4.8756 0 Td
([)Tj
0.83 0.64 0.02 0 k
(21)Tj
0 g
(].)Tj
2.0749 0 Td
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5.0003 0 Td
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(assessed)Tj
3.4696 0 Td
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2.0012 0 Td
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(examination,)Tj
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1.0148 0 Td
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(,)Tj
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3.5546 0 Td
[( \n)]TJ
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(,)Tj
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2.4038 0 Td
[(\r)]TJ
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2.8799 0 Td
(for)Tj
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(pathogenic)Tj
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(CSF)Tj
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3.1294 0 Td
(puncture)Tj
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0.6519 0 Td
(sitting)Tj
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(according)Tj
4.1896 0 Td
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1.0261 0 Td
(standard)Tj
3.719 0 Td
(procedures)Tj
4.6772 0 Td
([)Tj
0.83 0.64 0.02 0 k
(22)Tj
0 g
(].)Tj
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(4)Tj
0.6973 0 Td
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1.287 0 Td
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1.8425 0 Td
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(diagnosis)Tj
3.9628 0 Td
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1.0148 0 Td
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1.8198 0 Td
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1.0148 0 Td
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1.7291 0 Td
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(contaminations)Tj
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1.7291 0 Td
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1.3889 0 Td
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1.8879 0 Td
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1.7007 0 Td
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(\(1600)Tj
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-36.1131 -1.2983 Td
(10)Tj
1.1678 0 Td
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2.1997 0 Td
(and)Tj
1.7291 0 Td
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(30)Tj
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(7.5)Tj
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1.2869 0 Td
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5.3971 0 Td
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1.6044 0 Td
(Z)Tj
0.8221 0 Td
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2.3357 0 Td
(\(Sarstedt,)Tj
3.9742 0 Td
(Germany\),)Tj
4.5524 0 Td
(incubated)Tj
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1.389 0 Td
(10)Tj
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1.6781 0 Td
(cen-)Tj
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2.4604 0 Td
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0.9128 0 Td
(4C,)Tj
1.9729 0 Td
(10)Tj
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1.7291 0 Td
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(3040)Tj
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1.8539 0 Td
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(-80C)Tj
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1.7575 0 Td
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1.7801 0 Td
(CSF)Tj
1.8879 0 Td
(and)Tj
1.7291 0 Td
(serum)Tj
2.7213 0 Td
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3.3845 0 Td
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0.9524 0 Td
(no)Tj
1.2756 0 Td
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2.0296 0 Td
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1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 291.685 cm
BT
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3.4204 0 Td
(analyses)Tj
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0.6577 0 Td
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4.0818 0 Td
(expansion,)Tj
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(analysis)Tj
3.3278 0 Td
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1.3833 0 Td
(confirmation)Tj
-31.6741 -1.3039 Td
(\(Akimoto)Tj
4.1385 0 Td
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0.9411 0 Td
(al.,)Tj
1.3493 0 Td
(2014\))Tj
2.4661 0 Td
([)Tj
0.83 0.64 0.02 0 k
(23)Tj
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(].)Tj
2.075 0 Td
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1.1111 0 Td
(samples)Tj
3.3789 0 Td
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2.2054 0 Td
(participants)Tj
4.9605 0 Td
(with)Tj
1.9956 0 Td
(a)Tj
0.6577 0 Td
(familial)Tj
3.2201 0 Td
(history)Tj
3.0047 0 Td
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1.0148 0 Td
(a)Tj
0.6576 0 Td
(neurode-)Tj
-33.1764 -1.2983 Td
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4.3313 0 Td
(disease,)Tj
3.2428 0 Td
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1.1452 0 Td
(exons)Tj
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3.4526 0 Td
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[(\r)]TJ
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2.88 0 Td
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1.7348 0 Td
[( \n)]TJ
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2.177 0 Td
(were)Tj
2.1203 0 Td
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-33.0517 -1.2982 Td
(by)Tj
1.1792 0 Td
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2.9366 0 Td
(sequencing)Tj
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(\(details)Tj
3.118 0 Td
(available)Tj
3.668 0 Td
(upon)Tj
2.3188 0 Td
(request\).)Tj
3.702 0 Td
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1.7801 0 Td
(sequencing)Tj
4.7169 0 Td
(results)Tj
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-33.0687 -1.3039 Td
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4.3029 0 Td
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(NM_005910,)Tj
5.4254 0 Td
(NM_002087\))Tj
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1.474 0 Td
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3.3619 0 Td
(systems\).)Tj
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Q
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11.9999 0 0 11.9999 200.0125 151.9937 cm
BT
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1 TL
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4.8709 0 Td
(markers)Tj
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Q
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1 TL
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1.7801 0 Td
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3.7928 0 Td
(IgG,)Tj
1.9672 0 Td
(IgA)Tj
1.7064 0 Td
(and)Tj
1.7348 0 Td
(IgM)Tj
1.9162 0 Td
(in)Tj
1.0375 0 Td
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1.8822 0 Td
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1.7348 0 Td
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1.8085 0 Td
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4.8472 0 Td
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1.0148 0 Td
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-33.7604 -1.2982 Td
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(\(Jesse)Tj
2.4605 0 Td
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0.9411 0 Td
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1.3492 0 Td
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([)Tj
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(24)Tj
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1.4684 0 Td
(neurochemical)Tj
6.1624 0 Td
(lab)Tj
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(depart-)Tj
-33.8114 -1.2983 Td
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2.3073 0 Td
(of)Tj
1.0148 0 Td
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4.4617 0 Td
(in)Tj
1.0318 0 Td
(Ulm.)Tj
2.2507 0 Td
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5.8961 0 Td
(available)Tj
3.668 0 Td
(ELISA)Tj
2.8233 0 Td
(kits)Tj
1.644 0 Td
(were)Tj
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2.058 0 Td
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1.3833 0 Td
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-30.665 -1.3039 Td
(light)Tj
2.0239 0 Td
(chain)Tj
2.4207 0 Td
(\(NfL\))Tj
2.4605 0 Td
(\(IBL,)Tj
2.245 0 Td
(Hamburg,)Tj
4.337 0 Td
(Germany\),)Tj
4.5524 0 Td
(phosphorylated)Tj
6.4403 0 Td
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(an)Tj
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(l)Tj
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(containing)Tj
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(0.8)Tj
/F12 1 Tf
1.3776 0 Td
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(g/)Tj
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[()]TJ
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(MS2)Tj
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(\(Roche\))Tj
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(S3)Tj
1.4967 0 Td
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(\).)Tj
-34.7128 -1.2982 Td
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1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 568.0629 cm
BT
/F11 1 Tf
1 TL
-0.0033 Tc
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Q
q
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1 J
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1 TL
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(groups,)Tj
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5.108 0 Td
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0 Tc
0.771 0 Td
(<)Tj
/F5 1 Tf
-0.004 Tc
0.9865 0 Td
(0.05)Tj
1.8765 0 Td
(\(two)Tj
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(sided\))Tj
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(consid-)Tj
-34.4123 -1.2983 Td
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1.9672 0 Td
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1.0148 0 Td
(statistically)Tj
4.6091 0 Td
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1.7801 0 Td
(false)Tj
1.9729 0 Td
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(controlled)Tj
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-32.7739 -1.3039 Td
(Hochberg)Tj
4.2122 0 Td
(procedure)Tj
4.3143 0 Td
(when)Tj
2.4038 0 Td
(conducting)Tj
4.7565 0 Td
(multiple)Tj
3.5659 0 Td
(comparisons.)Tj
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-32.156 -1.2982 Td
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3.4242 0 Td
(r)Tj
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(data)Tj
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(or)Tj
1.0999 0 Td
(the)Tj
1.4683 0 Td
(Spearman)Tj
4.2463 0 Td
(test)Tj
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2.4038 0 Td
(data)Tj
1.9162 0 Td
(were)Tj
2.1203 0 Td
(not)Tj
1.576 0 Td
(nor-)Tj
-34.5767 -1.2983 Td
(mally)Tj
2.4207 0 Td
(distributed)Tj
4.5978 0 Td
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0.9524 0 Td
(a)Tj
0.652 0 Td
(5%)Tj
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(significance)Tj
4.9379 0 Td
(level.)Tj
2.2394 0 Td
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1.3379 0 Td
(evaluate)Tj
3.464 0 Td
(diagnostic)Tj
4.3199 0 Td
(accuracy)Tj
3.7077 0 Td
(we)Tj
1.3323 0 Td
(used)Tj
2.0579 0 Td
(receiver)Tj
-33.4712 -1.3039 Td
(operating)Tj
4.0535 0 Td
(curves)Tj
2.7779 0 Td
(and)Tj
1.7291 0 Td
(discriminant)Tj
5.3575 0 Td
(analysis.)Tj
3.5489 0 Td
(Unsupervised)Tj
5.743 0 Td
(hierarchical)Tj
4.9379 0 Td
(clustering)Tj
4.1499 0 Td
(and)Tj
1.7291 0 Td
(differen-)Tj
-34.0268 -1.2983 Td
(tial)Tj
1.4626 0 Td
(correlations)Tj
4.9776 0 Td
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2.126 0 Td
(calculated)Tj
4.2066 0 Td
(by)Tj
1.1792 0 Td
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2.3867 0 Td
(the)Tj
1.4741 0 Td
(DiffCorr)Tj
3.7076 0 Td
(v0.4.1)Tj
2.5569 0 Td
(package)Tj
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1.3833 0 Td
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0.8447 0 Td
([)Tj
0.83 0.64 0.02 0 k
(32)Tj
0 g
(].)Tj
-28.522 -1.2983 Td
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4.9662 0 Td
(Factor)Tj
2.778 0 Td
(Analysis)Tj
3.5773 0 Td
(\(EFA\))Tj
2.6815 0 Td
(permits)Tj
3.2769 0 Td
(examination)Tj
5.2327 0 Td
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1.0148 0 Td
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1.9389 0 Td
(unmeasured)Tj
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(latent)Tj
2.4718 0 Td
(vari-)Tj
-34.3216 -1.3039 Td
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(\(factors\))Tj
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(summarize)Tj
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3.5262 0 Td
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(\(KMO\))Tj
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0 Tc
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/F5 1 Tf
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0 Tc
3.5773 0 Td
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4.1839 0 Td
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-34.2252 -1.3039 Td
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(\(v24\))Tj
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(statistical)Tj
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-30.4212 -1.3039 Td
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3.7643 0 Td
(\(R)Tj
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5.6183 0 Td
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2.1883 0 Td
(2008\).)Tj
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Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 247.9748 cm
BT
/F2 1 Tf
1 TL
-0.0033 Tc
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0 -1.4976 Td
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2.4992 0 Td
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Q
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1 j
1 J
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10 0 0 10 200.0125 212.9952 cm
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1 TL
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1.2642 0 Td
(summarized)Tj
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-34.8432 -1.2982 Td
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3.2031 0 Td
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1.0261 0 Td
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1.4684 0 Td
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1.6384 0 Td
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(\(p)Tj
/F13 1 Tf
0 Tc
(<)Tj
/F5 1 Tf
-0.004 Tc
(0.05\).)Tj
-33.6016 -1.3039 Td
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3.6566 0 Td
(protein)Tj
3.1521 0 Td
(biomarkers)Tj
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1.4683 0 Td
(AD)Tj
1.6385 0 Td
(patients)Tj
3.3675 0 Td
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-33.9758 -1.2983 Td
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1.0262 0 Td
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1.4683 0 Td
(bvFTD)Tj
3.0557 0 Td
(and)Tj
1.7291 0 Td
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(cases)Tj
2.2224 0 Td
(\(p)Tj
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0 Tc
(<)Tj
/F5 1 Tf
-0.004 Tc
(0.0001\).)Tj
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