%PDF-1.6
%
1 0 obj
<>
endobj
2 0 obj
<>stream
Elena Kilian, Jan S. Suchodolski, Katrin Hartmann, Ralf S. Mueller, Gerhard Wess, Stefan Unterer
Long-term effects of canine parvovirus infection in dogs
www.plosone.org
www.plosone.org
endstream
endobj
3 0 obj
<>/XObject<>>>/CropBox[0 0 612 792]/MediaBox[0 0 612 792]/Parent 10 0 R/Annots 11 0 R/Contents 12 0 R/TrimBox[0 0 612 792]>>
endobj
11 0 obj
[13 0 R 14 0 R 15 0 R 16 0 R 17 0 R 18 0 R 19 0 R 20 0 R 21 0 R 22 0 R 23 0 R 24 0 R 25 0 R 26 0 R]
endobj
13 0 obj
<>/Border[0 0 0]/Dest(Rpone.0192198.ref001)>>
endobj
14 0 obj
<>/Border[0 0 0]/Dest(Rpone.0192198.ref003)>>
endobj
15 0 obj
<>/Border[0 0 0]/Dest(Rpone.0192198.ref004)>>
endobj
16 0 obj
<>/Border[0 0 0]/Dest(Rpone.0192198.ref005)>>
endobj
17 0 obj
<>/Border[0 0 0]/Dest(Rpone.0192198.ref006)>>
endobj
18 0 obj
<>/Border[0 0 0]/Dest(Rpone.0192198.ref007)>>
endobj
19 0 obj
<>/Border[0 0 0]/Dest(Rpone.0192198.ref009)>>
endobj
20 0 obj
<>/Border[0 0 0]/Dest(Rpone.0192198.ref007)>>
endobj
21 0 obj
<>/Border[0 0 0]/Dest(Rpone.0192198.ref002)>>
endobj
22 0 obj
<>/Border[0 0 0]/Dest(Rpone.0192198.ref010)>>
endobj
23 0 obj
<>/Border[0 0 0]/Dest(Rpone.0192198.ref011)>>
endobj
24 0 obj
<>/Border[0 0 0]/Dest(Rpone.0192198.ref012)>>
endobj
25 0 obj
<>/Border[0 0 0]/Dest(Rpone.0192198.ref013)>>
endobj
26 0 obj
<>/Border[0 0 0]/A 27 0 R>>
endobj
27 0 obj
<>
endobj
12 0 obj
[28 0 R 29 0 R 30 0 R 31 0 R 32 0 R 33 0 R 34 0 R 35 0 R 36 0 R 37 0 R 38 0 R 39 0 R 40 0 R 41 0 R 42 0 R 43 0 R 44 0 R]
endobj
28 0 obj
<>stream
q
0.83 0.64 0.02 0 k
538.8661 688.0252 m
543.6283 688.0252 l
h
f*
548.7874 688.0252 m
553.5496 688.0252 l
h
f*
439.7669 662.0031 m
444.5291 662.0031 l
h
f*
389.1402 635.9811 m
393.8457 635.9811 l
h
f*
398.3244 635.9811 m
403.0866 635.9811 l
h
f*
440.3339 622.9984 m
445.0394 622.9984 l
h
f*
450.2551 622.9984 m
455.0173 622.9984 l
h
f*
500.485 610.0157 m
505.2472 610.0157 l
h
f*
442.5449 571.011 m
447.3071 571.011 l
h
f*
465.222 519.0236 m
474.7465 519.0236 l
h
f*
498.274 466.9795 m
507.7984 466.9795 l
h
f*
512.2205 466.9795 m
521.7449 466.9795 l
h
f*
372.2457 441.0142 m
381.7134 441.0142 l
h
f*
0 g
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 706.0535 cm
BT
/F2 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(Introduction)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 689.1023 cm
BT
/F7 1 Tf
1 TL
-0.004 Tc
0 0 Td
(Canine)Tj
3.101 0 Td
(parvovirus)Tj
4.4901 0 Td
(\(CPV\))Tj
2.8176 0 Td
(represents)Tj
4.32 0 Td
(a)Tj
0.6519 0 Td
(common)Tj
3.8438 0 Td
(viral)Tj
1.9956 0 Td
(cause)Tj
2.3867 0 Td
(of)Tj
1.0148 0 Td
(acute)Tj
2.3301 0 Td
(enteritis)Tj
3.4752 0 Td
(in)Tj
1.0375 0 Td
(dogs)Tj
2.0806 0 Td
([)Tj
0.83 0.64 0.02 0 k
(1)Tj
0 g
()Tj
0.83 0.64 0.02 0 k
(3)Tj
0 g
(].)Tj
2.5966 0 Td
(As)Tj
-36.1415 -1.3039 Td
(parvoviruses)Tj
5.2667 0 Td
(require)Tj
3.1124 0 Td
(cells)Tj
1.9219 0 Td
(with)Tj
1.9956 0 Td
(a)Tj
0.6576 0 Td
(high)Tj
2.0069 0 Td
(proliferation)Tj
5.2668 0 Td
(rate)Tj
1.7461 0 Td
(for)Tj
1.3833 0 Td
(replication)Tj
4.524 0 Td
(they)Tj
1.9276 0 Td
(have)Tj
2.0579 0 Td
(a)Tj
0.6577 0 Td
(high)Tj
2.0069 0 Td
(affinity)Tj
-34.5314 -1.2982 Td
(for)Tj
1.3832 0 Td
(the)Tj
1.4684 0 Td
(small)Tj
2.3244 0 Td
(intestine,)Tj
3.8778 0 Td
(bone)Tj
2.1996 0 Td
(marrow,)Tj
3.634 0 Td
(and)Tj
1.7291 0 Td
(lymphatic)Tj
4.2066 0 Td
(tissues)Tj
2.812 0 Td
([)Tj
0.83 0.64 0.02 0 k
(4)Tj
0 g
(].)Tj
1.5987 0 Td
(In)Tj
1.1055 0 Td
(puppies,)Tj
3.5773 0 Td
(CPV)Tj
2.1317 0 Td
(can)Tj
1.627 0 Td
(also)Tj
1.7632 0 Td
(affect)Tj
-35.4385 -1.2983 Td
(myocardial)Tj
4.7054 0 Td
(cells)Tj
1.9162 0 Td
(during)Tj
2.931 0 Td
(the)Tj
1.4684 0 Td
(time)Tj
2.0296 0 Td
(of)Tj
1.0148 0 Td
(high)Tj
2.0069 0 Td
(cell)Tj
1.559 0 Td
(turnover)Tj
3.7247 0 Td
(rate)Tj
1.7462 0 Td
(from)Tj
2.2053 0 Td
(the)Tj
1.4683 0 Td
(time)Tj
2.0296 0 Td
(of)Tj
1.0148 0 Td
(intrauterine)Tj
5.0003 0 Td
(devel-)Tj
-34.8205 -1.3039 Td
(opment)Tj
3.3335 0 Td
(until)Tj
2.1089 0 Td
(up)Tj
1.2643 0 Td
(to)Tj
1.0261 0 Td
(the)Tj
1.4684 0 Td
(age)Tj
1.542 0 Td
(of)Tj
1.0148 0 Td
(about)Tj
2.4945 0 Td
(two)Tj
1.7064 0 Td
(weeks)Tj
2.6135 0 Td
([)Tj
0.83 0.64 0.02 0 k
(5)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
1.2586 0 Td
(6)Tj
0 g
(])Tj
1.0375 0 Td
(leading)Tj
3.1294 0 Td
(to)Tj
1.0261 0 Td
(acute)Tj
2.3301 0 Td
(heart)Tj
2.2734 0 Td
(failure)Tj
2.7779 0 Td
(frequently)Tj
-32.4054 -1.2983 Td
(resulting)Tj
3.7303 0 Td
(in)Tj
1.0318 0 Td
(sudden)Tj
3.1351 0 Td
(death)Tj
2.4321 0 Td
(within)Tj
2.812 0 Td
(the)Tj
1.474 0 Td
(first)Tj
1.8028 0 Td
(eight)Tj
2.2054 0 Td
(weeks)Tj
2.6078 0 Td
(of)Tj
1.0148 0 Td
(life)Tj
1.4457 0 Td
([)Tj
0.83 0.64 0.02 0 k
(7)Tj
0 g
()Tj
0.83 0.64 0.02 0 k
(9)Tj
0 g
(].)Tj
2.5908 0 Td
(Structural)Tj
4.1953 0 Td
(changes)Tj
3.4015 0 Td
(in)Tj
1.0375 0 Td
(myo-)Tj
-34.9169 -1.2982 Td
(cardial)Tj
2.9253 0 Td
(tissue)Tj
2.4548 0 Td
(have)Tj
2.0636 0 Td
(been)Tj
2.1203 0 Td
(detected)Tj
3.5659 0 Td
(in)Tj
1.0375 0 Td
(puppies)Tj
3.3505 0 Td
(surviving)Tj
3.9345 0 Td
(acute)Tj
2.3301 0 Td
(CPV)Tj
2.1373 0 Td
(infection)Tj
3.787 0 Td
([)Tj
0.83 0.64 0.02 0 k
(7)Tj
0 g
(],)Tj
1.6044 0 Td
(however)Tj
3.6114 0 Td
(their)Tj
-34.9226 -1.304 Td
(clinical)Tj
3.0727 0 Td
(consequence)Tj
5.3404 0 Td
(is)Tj
0.8447 0 Td
(unclear.)Tj
3.4243 0 Td
(In)Tj
1.1055 0 Td
(the)Tj
1.4683 0 Td
(intestine,)Tj
3.8835 0 Td
(characteristic)Tj
5.5445 0 Td
(histologic)Tj
4.0875 0 Td
(findings)Tj
3.498 0 Td
(of)Tj
1.0147 0 Td
(parvovirus)Tj
-33.2841 -1.2982 Td
(enteritis)Tj
3.4752 0 Td
(include)Tj
3.1861 0 Td
(necrosis)Tj
3.4809 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4741 0 Td
(intestinal)Tj
3.9117 0 Td
(crypt)Tj
2.2847 0 Td
(epithelium,)Tj
4.7622 0 Td
(shortening)Tj
4.5411 0 Td
(or)Tj
1.0942 0 Td
(obliteration)Tj
4.8982 0 Td
(of)Tj
1.0148 0 Td
(villi,)Tj
-35.138 -1.2983 Td
(and)Tj
1.7291 0 Td
(dilation)Tj
3.3165 0 Td
(of)Tj
1.0148 0 Td
(intestinal)Tj
3.9118 0 Td
(crypts)Tj
2.6475 0 Td
(with)Tj
1.9956 0 Td
(necrotic)Tj
3.4809 0 Td
(cellular)Tj
3.1408 0 Td
(debris)Tj
2.6759 0 Td
([)Tj
0.83 0.64 0.02 0 k
(2)Tj
0 g
(].)Tj
1.6044 0 Td
(These)Tj
2.5681 0 Td
(changes)Tj
3.4016 0 Td
(as)Tj
1.0148 0 Td
(well)Tj
1.8198 0 Td
(as)Tj
1.0148 0 Td
(the)Tj
-35.3364 -1.2983 Td
(haemorrhagic)Tj
5.7883 0 Td
(diarrhoea)Tj
4.0875 0 Td
(seen)Tj
1.9729 0 Td
(in)Tj
1.0375 0 Td
(these)Tj
2.2563 0 Td
(dogs)Tj
2.0806 0 Td
(are)Tj
1.4457 0 Td
(associated)Tj
4.2576 0 Td
(with)Tj
1.9956 0 Td
(destruction)Tj
4.7735 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.474 0 Td
(intestinal)Tj
-32.1843 -1.3039 Td
(barrier.)Tj
3.1917 0 Td
(An)Tj
1.4514 0 Td
(intact)Tj
2.4888 0 Td
(intestinal)Tj
3.9118 0 Td
(barrier)Tj
2.965 0 Td
(is)Tj
0.8504 0 Td
(crucial)Tj
2.914 0 Td
(for)Tj
1.3833 0 Td
(the)Tj
1.4683 0 Td
(development)Tj
5.4141 0 Td
(and)Tj
1.7292 0 Td
(stimulation)Tj
4.7962 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4683 0 Td
(im-)Tj
-35.0473 -1.2982 Td
(mune)Tj
2.5398 0 Td
(system)Tj
2.9367 0 Td
(and)Tj
1.7291 0 Td
(establishment)Tj
5.7373 0 Td
(of)Tj
1.0148 0 Td
(oral)Tj
1.7801 0 Td
(tolerance.)Tj
4.1216 0 Td
(Severe)Tj
2.7892 0 Td
(destruction)Tj
4.7735 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4684 0 Td
(intestinal)Tj
3.9174 0 Td
(barrier)Tj
-33.8227 -1.2983 Td
(might)Tj
2.5965 0 Td
(lead)Tj
1.8538 0 Td
(to)Tj
1.0205 0 Td
(a)Tj
0.6576 0 Td
(higher)Tj
2.8006 0 Td
(risk)Tj
1.7178 0 Td
(for)Tj
1.3833 0 Td
(immunological)Tj
6.2986 0 Td
(diseases)Tj
3.3788 0 Td
(later)Tj
1.9956 0 Td
(in)Tj
1.0375 0 Td
(life)Tj
1.44 0 Td
([)Tj
0.83 0.64 0.02 0 k
(10)Tj
0 g
(].)Tj
-24.9844 -1.3039 Td
(Puppies)Tj
3.3958 0 Td
(with)Tj
1.9956 0 Td
(CPV)Tj
2.1373 0 Td
(enteritis)Tj
3.481 0 Td
(in)Tj
1.0318 0 Td
(combination)Tj
5.3517 0 Td
(with)Tj
1.9956 0 Td
(neutropenia)Tj
5.0853 0 Td
(are)Tj
1.4514 0 Td
(prone)Tj
2.5851 0 Td
(to)Tj
1.0262 0 Td
(become)Tj
3.3222 0 Td
(septic.)Tj
-34.0552 -1.2983 Td
(Therefore,)Tj
4.3936 0 Td
(aggressive)Tj
4.2463 0 Td
(intravenous,)Tj
5.1874 0 Td
(broad-spectrum,)Tj
6.8824 0 Td
(bactericidal)Tj
4.8416 0 Td
(antibiotic)Tj
4.0365 0 Td
(treatment)Tj
4.1386 0 Td
(is)Tj
0.8503 0 Td
(part)Tj
1.8369 0 Td
(of)Tj
-36.4136 -1.2982 Td
(the)Tj
1.4683 0 Td
(therapy.)Tj
3.4696 0 Td
(In)Tj
1.1111 0 Td
(humans,)Tj
3.6624 0 Td
(recent)Tj
2.7099 0 Td
(studies)Tj
2.9877 0 Td
(have)Tj
2.0579 0 Td
(shown)Tj
2.8517 0 Td
(that)Tj
1.7744 0 Td
(early-life)Tj
3.7247 0 Td
(exposure)Tj
3.8211 0 Td
(to)Tj
1.0205 0 Td
(antibiotics)Tj
4.3993 0 Td
(is)Tj
-35.0586 -1.304 Td
(associated)Tj
4.2576 0 Td
(with)Tj
1.9955 0 Td
(an)Tj
1.2019 0 Td
(increased)Tj
4.0025 0 Td
(risk)Tj
1.7121 0 Td
(for)Tj
1.389 0 Td
(the)Tj
1.4683 0 Td
(development)Tj
5.4085 0 Td
(of)Tj
1.0148 0 Td
(allergic)Tj
3.1011 0 Td
(disorders)Tj
3.9344 0 Td
([)Tj
0.83 0.64 0.02 0 k
(11)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
1.7348 0 Td
(12)Tj
0 g
(].)Tj
1.7405 0 Td
(Metadata)Tj
-32.961 -1.2982 Td
(analysis)Tj
3.3278 0 Td
(suggests)Tj
3.4809 0 Td
(an)Tj
1.2019 0 Td
(association)Tj
4.6261 0 Td
(between)Tj
3.532 0 Td
(acute)Tj
2.3244 0 Td
(gastroenteritis)Tj
5.9187 0 Td
(and)Tj
1.7291 0 Td
(development)Tj
5.4085 0 Td
(of)Tj
1.0148 0 Td
(post-infec-)Tj
-32.5642 -1.2983 Td
(tious)Tj
2.1769 0 Td
(irritable)Tj
3.4073 0 Td
(bowel)Tj
2.5908 0 Td
(syndrome)Tj
4.2293 0 Td
(in)Tj
1.0375 0 Td
(humans)Tj
3.4412 0 Td
([)Tj
0.83 0.64 0.02 0 k
(13)Tj
0 g
(].)Tj
2.0749 0 Td
(Taken)Tj
2.7326 0 Td
(together,)Tj
3.7587 0 Td
(there)Tj
2.2677 0 Td
(is)Tj
0.8448 0 Td
(reason)Tj
2.8686 0 Td
(to)Tj
1.0261 0 Td
(suspect)Tj
3.1295 0 Td
(that)Tj
-35.5859 -1.2983 Td
(severe)Tj
2.6758 0 Td
(enteritis)Tj
3.481 0 Td
(in)Tj
1.0318 0 Td
(combination)Tj
5.3517 0 Td
(with)Tj
1.9956 0 Td
(antibiotic)Tj
4.0365 0 Td
(exposure)Tj
3.8154 0 Td
(in)Tj
1.0375 0 Td
(early)Tj
2.1487 0 Td
(life)Tj
1.4456 0 Td
(might)Tj
2.5965 0 Td
(also)Tj
1.7688 0 Td
(predispose)Tj
-31.3849 -1.3039 Td
(dogs)Tj
2.0806 0 Td
(to)Tj
1.0261 0 Td
(signs)Tj
2.2224 0 Td
(of)Tj
1.0147 0 Td
(chronic)Tj
3.2882 0 Td
(gastrointestinal)Tj
6.3496 0 Td
(disease)Tj
3.016 0 Td
(later.)Tj
-17.8014 -1.2982 Td
(So)Tj
1.2075 0 Td
(far,)Tj
1.5364 0 Td
(information)Tj
5.074 0 Td
(about)Tj
2.4944 0 Td
(long-term)Tj
4.252 0 Td
(consequences)Tj
5.6976 0 Td
(of)Tj
1.0148 0 Td
(CPV)Tj
2.1373 0 Td
(infection)Tj
3.7927 0 Td
(is)Tj
0.8447 0 Td
(sparse,)Tj
2.914 0 Td
(and)Tj
1.7292 0 Td
(only)Tj
1.9785 0 Td
(few)Tj
-0.01 Tc
-35.8693 -1.2983 Td
(studies)Tj
2.9423 0 Td
(in)Tj
1.0261 0 Td
(veterinary)Tj
4.2066 0 Td
(medicine)Tj
3.8721 0 Td
(address)Tj
3.1861 0 Td
(long-term)Tj
4.1953 0 Td
(effects)Tj
2.6815 0 Td
(of)Tj
1.0035 0 Td
(acute)Tj
2.2961 0 Td
(intestinal)Tj
3.855 0 Td
(disorders)Tj
3.8835 0 Td
(in)Tj
1.0261 0 Td
(general.)Tj
-34.1742 -1.3039 Td
(However,)Tj
4.0251 0 Td
(this)Tj
1.6554 0 Td
(knowledge)Tj
4.4844 0 Td
(would)Tj
2.6873 0 Td
(be)Tj
1.1338 0 Td
(important)Tj
4.2293 0 Td
(to)Tj
1.0148 0 Td
(establish)Tj
3.5886 0 Td
(long-term)Tj
4.2009 0 Td
(prognosis.)Tj
4.286 0 Td
(Thus,)Tj
2.4434 0 Td
(the)Tj
1.4514 0 Td
(aim)Tj
-35.2004 -1.2983 Td
(of)Tj
1.0034 0 Td
(this)Tj
1.6498 0 Td
(study)Tj
2.3584 0 Td
(was)Tj
1.6781 0 Td
(to)Tj
1.0148 0 Td
(evaluate)Tj
3.4129 0 Td
(whether)Tj
3.4355 0 Td
(dogs)Tj
2.058 0 Td
(that)Tj
1.7574 0 Td
(survived)Tj
3.5547 0 Td
(a)Tj
0.6519 0 Td
(clinical)Tj
3.0274 0 Td
(manifestation)Tj
5.6352 0 Td
(of)Tj
1.0035 0 Td
(CPV)Tj
2.1203 0 Td
(infec-)Tj
-34.3613 -1.2983 Td
(tion)Tj
1.8141 0 Td
(prompting)Tj
4.4731 0 Td
(intensive)Tj
3.753 0 Td
(antibiotic)Tj
3.9741 0 Td
(treatment)Tj
4.0819 0 Td
(have)Tj
2.0296 0 Td
(an)Tj
1.1906 0 Td
(increased)Tj
3.9401 0 Td
(risk)Tj
1.6894 0 Td
(for)Tj
1.3663 0 Td
(chronic)Tj
3.2428 0 Td
(gastrointestinal)Tj
-31.555 -1.3039 Td
(and)Tj
1.7121 0 Td
(skin)Tj
1.8708 0 Td
(disorders,)Tj
4.0989 0 Td
(such)Tj
2.0353 0 Td
(as)Tj
1.0034 0 Td
(food)Tj
2.0296 0 Td
(or)Tj
1.0828 0 Td
(environmental)Tj
6.0321 0 Td
(allergies,)Tj
3.6283 0 Td
(or)Tj
1.0829 0 Td
(cardiac)Tj
3.0614 0 Td
(diseases)Tj
3.3278 0 Td
(later)Tj
1.9673 0 Td
(in)Tj
1.0204 0 Td
(life.)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 308.0125 cm
BT
/F2 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(Materials)Tj
4.5071 0 Td
(and)Tj
1.989 0 Td
(methods)Tj
/F11 1 Tf
-6.4961 -1.4976 Td
(Study)Tj
2.6173 0 Td
(design)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 273.033 cm
BT
/F7 1 Tf
1 TL
-0.004 Tc
0 0 Td
(The)Tj
1.7744 0 Td
(study)Tj
2.3811 0 Td
(was)Tj
1.6895 0 Td
(designed)Tj
3.7587 0 Td
(as)Tj
1.0091 0 Td
(a)Tj
0.6463 0 Td
(prospective)Tj
4.7735 0 Td
(survey)Tj
2.8063 0 Td
(in)Tj
1.0318 0 Td
(combination)Tj
5.3348 0 Td
(with)Tj
1.9899 0 Td
(retrospective)Tj
5.3574 0 Td
(data)Tj
1.9049 0 Td
(acquisi-)Tj
-34.4577 -1.2982 Td
(tion.)Tj
2.0636 0 Td
(A)Tj
0.907 0 Td
(questionnaire)Tj
5.7033 0 Td
(with)Tj
1.9956 0 Td
(37)Tj
1.1735 0 Td
(questions)Tj
4.0195 0 Td
(was)Tj
1.7008 0 Td
(sent)Tj
1.8482 0 Td
(to)Tj
1.0261 0 Td
(owners)Tj
3.1181 0 Td
(of)Tj
1.0148 0 Td
(dogs)Tj
2.0806 0 Td
(that)Tj
1.7745 0 Td
(had)Tj
1.7121 0 Td
(recovered)Tj
4.1442 0 Td
(from)Tj
2.2054 0 Td
(a)Tj
-36.4873 -1.2983 Td
(clinical)Tj
3.0727 0 Td
(manifestation)Tj
5.7146 0 Td
(of)Tj
1.0148 0 Td
(CPV)Tj
2.1373 0 Td
(infection.)Tj
4.0195 0 Td
(For)Tj
1.6271 0 Td
(comparison,)Tj
5.1987 0 Td
(the)Tj
1.4683 0 Td
(same)Tj
2.2621 0 Td
(questionnaire)Tj
5.7032 0 Td
(was)Tj
1.7008 0 Td
(sent)Tj
1.8482 0 Td
(to)Tj
-35.7673 -1.3039 Td
(owners)Tj
3.1124 0 Td
(of)Tj
1.0148 0 Td
(dogs)Tj
2.0806 0 Td
(that)Tj
1.7801 0 Td
(had)Tj
1.7121 0 Td
(never)Tj
2.4378 0 Td
(experienced)Tj
5.0343 0 Td
(clinical)Tj
3.0784 0 Td
(signs)Tj
2.2224 0 Td
(consistent)Tj
4.2576 0 Td
(with)Tj
1.9956 0 Td
(CPV)Tj
2.1373 0 Td
(infection.)Tj
4.0195 0 Td
(Dogs)Tj
-34.8829 -1.2983 Td
(in)Tj
1.0318 0 Td
(the)Tj
1.474 0 Td
(CPV)Tj
2.1373 0 Td
(and)Tj
1.7291 0 Td
(control)Tj
3.1181 0 Td
(group)Tj
2.6135 0 Td
(were)Tj
2.1203 0 Td
(identified)Tj
4.0592 0 Td
(by)Tj
1.1792 0 Td
(reviewing)Tj
4.1272 0 Td
(medical)Tj
3.3619 0 Td
(records)Tj
3.2031 0 Td
(from)Tj
2.2054 0 Td
(the)Tj
1.474 0 Td
(Clinic)Tj
2.6362 0 Td
(of)Tj
-36.4703 -1.2982 Td
(Small)Tj
2.4377 0 Td
(Animal)Tj
3.2202 0 Td
(Internal)Tj
3.4355 0 Td
(Medicine)Tj
3.9912 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4683 0 Td
(LMU)Tj
2.3868 0 Td
(Munich,)Tj
3.634 0 Td
(Germany,)Tj
4.2122 0 Td
(from)Tj
2.2054 0 Td
(July)Tj
1.7801 0 Td
(1997)Tj
2.1203 0 Td
(to)Tj
1.0262 0 Td
(December)Tj
-32.9327 -1.3039 Td
(2013.)Tj
2.347 0 Td
(Only)Tj
2.2167 0 Td
(dogs)Tj
2.0806 0 Td
(monitored)Tj
4.4901 0 Td
(for)Tj
1.3833 0 Td
(at)Tj
0.9524 0 Td
(least)Tj
1.9842 0 Td
(one)Tj
1.7008 0 Td
(year)Tj
1.9049 0 Td
(after)Tj
2.0353 0 Td
(presentation)Tj
5.2157 0 Td
(were)Tj
2.1203 0 Td
(included)Tj
3.7133 0 Td
(in)Tj
1.0375 0 Td
(the)Tj
1.4683 0 Td
(study.)Tj
-34.6504 -1.2983 Td
(Before)Tj
2.8119 0 Td
(sending)Tj
3.3619 0 Td
(out)Tj
1.5533 0 Td
(the)Tj
1.4684 0 Td
(questionnaires,)Tj
6.2929 0 Td
(owners)Tj
3.1124 0 Td
(of)Tj
1.0148 0 Td
(dogs)Tj
2.0806 0 Td
(suitable)Tj
3.2882 0 Td
(for)Tj
1.3833 0 Td
(the)Tj
1.4683 0 Td
(study)Tj
2.3924 0 Td
(were)Tj
2.1203 0 Td
(contacted)Tj
4.1046 0 Td
(by)Tj
-36.4533 -1.2983 Td
(telephone)Tj
4.1328 0 Td
(and)Tj
1.7292 0 Td
(asked)Tj
2.4661 0 Td
(for)Tj
1.3833 0 Td
(their)Tj
2.1089 0 Td
(willingness)Tj
4.6375 0 Td
(to)Tj
1.0261 0 Td
(participate.)Tj
-16.2877 -1.3039 Td
(This)Tj
1.9899 0 Td
(study)Tj
2.3867 0 Td
(was)Tj
1.7008 0 Td
(approved)Tj
3.9742 0 Td
(by)Tj
1.1792 0 Td
(the)Tj
1.474 0 Td
(ethics)Tj
2.5171 0 Td
(committee)Tj
4.5014 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4683 0 Td
(Centre)Tj
2.9481 0 Td
(of)Tj
1.0147 0 Td
(Veterinary)Tj
4.5071 0 Td
(Medicine,)Tj
-31.8725 -1.2983 Td
(LMU)Tj
2.3867 0 Td
(Munich,)Tj
3.634 0 Td
(Germany)Tj
3.9855 0 Td
(\(approval)Tj
4.0422 0 Td
(number:)Tj
3.6396 0 Td
(96-25-09-2017\).)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 112.9889 cm
BT
/F11 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(CPV)Tj
2.1968 0 Td
(group)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 95.9811 cm
BT
/F7 1 Tf
1 TL
-0.004 Tc
0 0 Td
(Initially,)Tj
3.5489 0 Td
(237)Tj
1.6441 0 Td
(dogs)Tj
2.0806 0 Td
(suffering)Tj
3.7587 0 Td
(from)Tj
2.2054 0 Td
(a)Tj
0.6576 0 Td
(clinical)Tj
3.0727 0 Td
(manifestation)Tj
5.7146 0 Td
(of)Tj
1.0148 0 Td
(CPV)Tj
2.1373 0 Td
(infection)Tj
3.7928 0 Td
(were)Tj
2.126 0 Td
(included.)Tj
-31.7535 -1.2982 Td
(Diagnosis)Tj
4.1669 0 Td
(was)Tj
1.6951 0 Td
(based)Tj
2.4774 0 Td
(on)Tj
1.2756 0 Td
(typical)Tj
2.8573 0 Td
(clinical)Tj
3.0784 0 Td
(signs)Tj
2.2224 0 Td
(in)Tj
1.0374 0 Td
(conjunction)Tj
5.074 0 Td
(with)Tj
1.9956 0 Td
(a)Tj
0.6576 0 Td
(positive)Tj
3.3166 0 Td
(faecal)Tj
2.4661 0 Td
(antigen)Tj
ET
Q
q
1 j
1 J
0 w
576 737.1 m
36 737.1 l
36 737.6 l
576 737.6 l
f*
36 741.2598 107.1496 23.6976 re
W* n
q
107.0929 0 0 23.6409 36 741.3165 cm
q
/I0 Do
Q
Q
Q
q
0 0 612 792 re
W* n
1 j
1 J
0 w
7.9999 0 0 7.9999 457.7952 745.7952 cm
BT
/F0 1 Tf
1 TL
-0.005 Tc
0 0 Td
(Long-term)Tj
4.7055 0 Td
(effects)Tj
3.1252 0 Td
(of)Tj
1.0347 0 Td
(CPV)Tj
2.2535 0 Td
(infection)Tj
ET
Q
q
1 j
1 J
0 w
36 48.0002 m
576 48.0002 l
576 47.5002 l
36 47.5002 l
f*
0.83 0.64 0.02 0 k
81.5811 34.9228 m
237.8835 34.9228 l
h
f*
0 g
7.9999 0 0 7.9999 36 36 cm
BT
/F0 1 Tf
1 TL
-0.005 Tc
0 0 Td
(PLOS)Tj
2.8559 0 Td
(ONE)Tj
2.3669 0 Td
(|)Tj
0.83 0.64 0.02 0 k
0.4748 0 Td
(https://doi.or)Tj
5.4142 0 Td
(g/10.137)Tj
3.8198 0 Td
(1/journal.po)Tj
5.1236 0 Td
(ne.01921)Tj
4.089 0 Td
(98)Tj
0 g
2.0906 0 Td
(March)Tj
2.9622 0 Td
(16,)Tj
1.5874 0 Td
(2018)Tj
34.3562 0 Td
(2)Tj
0.7654 0 Td
(/)Tj
ET
endstream
endobj
29 0 obj
<>stream
endstream
endobj
30 0 obj
<>stream
endstream
endobj
31 0 obj
<>stream
endstream
endobj
32 0 obj
<>stream
endstream
endobj
33 0 obj
<>stream
endstream
endobj
34 0 obj
<>stream
endstream
endobj
35 0 obj
<>stream
endstream
endobj
36 0 obj
<>stream
endstream
endobj
37 0 obj
<>stream
endstream
endobj
38 0 obj
<>stream
endstream
endobj
39 0 obj
<>stream
endstream
endobj
40 0 obj
<>stream
endstream
endobj
41 0 obj
<>stream
endstream
endobj
42 0 obj
<>stream
endstream
endobj
43 0 obj
<>stream
endstream
endobj
44 0 obj
<>stream
BT
66.402 0 Td
(11)Tj
ET
Q
endstream
endobj
45 0 obj
<>/XObject<>>>/CropBox[0 0 612 792]/MediaBox[0 0 612 792]/Parent 10 0 R/Annots 49 0 R/Contents 50 0 R/TrimBox[0 0 612 792]>>
endobj
46 0 obj
<>
endobj
51 0 obj
<>
endobj
54 0 obj
<>stream
MinionPro-Regular 6 )
H? HD H\ ' - 3 > H N T Z ` j q t { +2=CIU[cnz~
"(.9CIOU[elov|&-8>DPV^iuy &+/49@DGLPU[]_ahjmru|
&-4;BIPW^elsz
")07>ELSZahov} %,3:AHOV]dkry#/;JTey ! ( / 6 = D K R Y ` g n u |
$
+
2
9
@
G
N
U
\
c
j
q
x
'.5<CJQX_fmt{ #*18?FMT[bkry
"
)
0
7
>
E
J
O
W
d
q
v
$+29@GNU\cjqx '.5<CJQX_fmt{ #*18?FMT[bipw~
&-4;BIPW^elsz !(/6=DOVcpuz-B\v$<Tdy*5@Tanz!2>O_fmt{ $-6?HQZclu~ )2;DMV^gpy $-6?HQZclu~ )2;DM\enwcommaaccentAbreveAmacronAogonekAEacuteCacuteCcaronCcircumflexCdotaccentDcaronDcroatEbreveEcaronEdotaccentEmacronEngEogonekGbreveGcircumflexGcommaaccentGdotaccentHbarHcircumflexIbreveIJImacronIogonekItildeJcircumflexKcommaaccentLacuteLcaronLcommaaccentLdotNacuteNcaronNcommaaccentObreveOhungarumlautOmacronOslashacuteRacuteRcaronRcommaaccentSacuteScedillaScircumflexScommaaccentTbarTcaronTcommaaccentUbreveUhungarumlautUmacronUogonekUringUtildeWacuteWcircumflexWdieresisWgraveYcircumflexYgraveZacuteZdotaccentIdotaccentabreveamacronaogonekaeacutecacuteccaronccircumflexcdotaccentdcarondcroatebreveecaronedotaccentemacronengeogonekgbrevegcircumflexgcommaaccentgdotaccenthbarhcircumflexibreveijimacroniogonekitildejcircumflexkcommaaccentlacutelcaronlcommaaccentldotnacutencaronncommaaccentobreveohungarumlautomacronoslashacuteracutercaronrcommaaccentsacutescedillascircumflexscommaaccenttbartcarontcommaaccentubreveuhungarumlautumacronuogonekuringutildewacutewcircumflexwdieresiswgraveycircumflexygravezacutezdotaccentkgreenlandiclongsnapostrophetonosdieresistonosAlphaBetaGammaDeltaEpsilonZetaEtaThetaIotaKappaLambdaMuNuXiOmicronPiRhoSigmaTauUpsilonPhiChiPsiOmegaAlphatonosEpsilontonosEtatonosIotatonosIotadieresisOmicrontonosUpsilontonosUpsilondieresisOmegatonosuni1FBBuni1F09uni1F0Duni1F0Buni1F0Funi1FB8uni1FBAuni1FBCuni1F89uni1F8Duni1F8Buni1F8Funi1F88uni1F8Cuni1F8Auni1F8Euni1F08uni1F0Cuni1F0Auni1F0Euni1FB9uni1FC9uni1F19uni1F1Duni1F1Buni1FC8uni1F18uni1F1Cuni1F1Auni1FCBuni1F29uni1F2Duni1F2Buni1F2Funi1FCAuni1FCCuni1F99uni1F9Duni1F9Buni1F9Funi1F98uni1F9Cuni1F9Auni1F9Euni1F28uni1F2Cuni1F2Auni1F2Euni1FDBuni1F39uni1F3Duni1F3Buni1F3Funi1FD8uni1FDAuni1F38uni1F3Cuni1F3Auni1F3Euni1FD9uni1FFBuni1F69uni1F6Duni1F6Buni1F6Funi1FFAuni1FFCuni1FA9uni1FADuni1FABuni1FAFuni1FA8uni1FACuni1FAAuni1FAEuni1F68uni1F6Cuni1F6Auni1F6Euni1FF9uni1F49uni1F4Duni1F4Buni1FF8uni1F48uni1F4Cuni1F4Auni1FECuni1FEBuni1F59uni1F5Duni1F5Buni1F5Funi1FE8uni1FEAuni1FE9alphabetagammadeltaepsilonzetaetathetaiotakappalambdanuxiomicronpirhosigmatauupsilonphichipsiomegaalphatonosepsilontonosetatonosiotatonosiotadieresisomicrontonosupsilontonosupsilondieresisomegatonosiotadieresistonosupsilondieresistonosuni03C2uni0374uni0375uni037Euni03D0uni03DAuni03DEuni03E0uni03F0uni1FBDuni1FBEuni1FC1uni1FCDuni1FCEuni1FCFuni1FDDuni1FDEuni1FDFuni1FEDuni1FEEuni1FFEuni1F00uni1F01uni1F02uni1F03uni1F04uni1F05uni1F06uni1F07uni1F10uni1F11uni1F12uni1F13uni1F14uni1F15uni1F20uni1F21uni1F22uni1F23uni1F24uni1F25uni1F26uni1F27uni1F30uni1F31uni1F32uni1F33uni1F34uni1F35uni1F36uni1F37uni1F40uni1F41uni1F42uni1F43uni1F44uni1F45uni1F50uni1F51uni1F52uni1F53uni1F54uni1F55uni1F56uni1F57uni1F60uni1F61uni1F62uni1F63uni1F64uni1F65uni1F66uni1F67uni1F70uni1F71uni1F72uni1F73uni1F74uni1F75uni1F76uni1F77uni1F78uni1F79uni1F7Auni1F7Buni1F7Cuni1F7Duni1F80uni1F81uni1F82uni1F83uni1F84uni1F85uni1F86uni1F87uni1F90uni1F91uni1F92uni1F93uni1F94uni1F95uni1F96uni1F97uni1FA0uni1FA1uni1FA2uni1FA3uni1FA4uni1FA5uni1FA6uni1FA7uni1FB0uni1FB1uni1FB2uni1FB3uni1FB6uni1FB7uni1FC2uni1FC3uni1FC4uni1FC6uni1FC7uni1FD0uni1FD1uni1FD2uni1FD3uni1FD6uni1FD7uni1FE0uni1FE1uni1FE2uni1FE3uni1FE4uni1FE5uni1FE6uni1FF2uni1FF3uni1FF4uni1FF6uni1FF7uni1FB4uni1FE7uniEFD5anoteleiauni03D1uni03D5uni03D6franclirapesetaEuroafii61289estimatedpartialdiffproductsummationuni2219radicalinfinityintegralapproxequalnotequallessequalgreaterequallozengeuni02C9uniEFEDuniEFEEuniEFF1uniEFF2uniEFF3uniEFF5uniEFF7AcuteCaronDieresisDieresisAcuteDieresisGraveGraveHungarumlautMacroncyrBrevecyrFlexdblGravecyrbrevecyrflexdblgravedieresisacutedieresisgraveuniF635uniF637uniF638uniF639uniF6DCuniF63AuniF63BuniF63CuniF63DuniF63EuniF63FuniF640uniF641uniF642uniF628uniF643uniF644uniF645uniF646uniF647uniF648uniF649uniF64AuniF64BuniF64CuniF64DuniF64EuniF64FuniF650uniF651uniF652uniF653uniF654uniF655uniF656uniF657uniF658uniF659uniF65AuniF65BuniF65CuniF65DuniF65EuniF65FuniF660uniF629uniF62AuniF62BuniF62CuniF62DuniF661uniF662uniF663uniF664uniF665uniF666uniF667uniF668uniF669uniF66AuniF66BuniF66CuniF62EuniF62FuniF630uniF631uniF632uniF66DuniF66EuniF66FuniF670uniF671uniF672uniF673uniF674uniF675uniF676uniF677uniF678uniF679uniF67AuniF67BuniF67CuniF67DuniF67EuniF67FuniF680uniF681uniF682uniF683uniF684uniF685uniF686uniF687uniF688uniF689uniF68AuniF68BuniF68CuniF68DuniF68EuniF68FuniF690uniF691uniF692uniF693uniF694uniF695uniF696uniF697uniF698uniF699uniF69AuniF69BuniF69CuniF69DuniF69EuniF69FuniF6A0uniF6A1uniF6A2uniF6A3uniF6A4uniF6A5uniF6A6uniF6A7uniF6A8uniF6A9uniF6AAuniF6ABuniF6ACuniF6ADuniF6AEuniF6AFuniF6B0uniF6B1uniF6B2uniF6B3uniF6B4uniF6B5uniF6B6uniF6B7uniF6B8uniF6B9uniF6BAuniF6BBuniF6BCuniF6BDuniF633c_hc_kc_tf_bf_f_bf_f_hf_f_kf_f_tf_hf_jf_f_jf_kf_ts_puniFB06T_hlongs_blongs_hlongs_ilongs_klongs_llongs_longsuniFB05longs_longs_ilongs_longs_la.ende.endm.endn.endr.endK.altR.altk.altcaron.altcommaaccent.altpeseta.altAlphaiotasub.altAlphaiotasubasper.altAlphaiotasubasperacute.altAlphaiotasubaspergrave.altAlphaiotasubaspertilde.altAlphaiotasublenis.altAlphaiotasublenisacute.altAlphaiotasublenisgrave.altAlphaiotasublenistilde.altEtaiotasub.altEtaiotasubasper.altEtaiotasubasperacute.altEtaiotasubaspergrave.altEtaiotasubaspertilde.altEtaiotasublenis.altEtaiotasublenisacute.altEtaiotasublenisgrave.altEtaiotasublenistilde.altOmegaiotasub.altOmegaiotasubasper.altOmegaiotasubasperacute.altOmegaiotasubaspergrave.altOmegaiotasubaspertilde.altOmegaiotasublenis.altOmegaiotasublenisacute.altOmegaiotasublenisgrave.altOmegaiotasublenistilde.altEuro.fittedcent.fittedcolonmonetary.fitteddollar.fittedflorin.fittedfranc.fittedlira.fittednumbersign.fittedsterling.fittedyen.fittedEuro.oldstylecolonmonetary.oldstyleestimated.oldstyleflorin.oldstylefranc.oldstylelira.oldstylenumbersign.oldstylesterling.oldstyleyen.oldstylefranc.taboldstylelira.taboldstyleorn.001orn.002orn.003orn.004orn.005orn.006orn.007orn.008orn.009orn.010orn.011orn.012orn.013orn.014orn.015orn.016orn.017orn.018orn.019orn.020orn.021orn.022orn.023afii10023afii10031afii10022afii10049T_h.caronafii10070afii10196afii10026afii10021afii10846afii10193afii10107afii10024afii10195afii10041afii10037afii10109afii10053afii10045afii10108afii10040afii10104afii10036afii10078afii10074afii10060afii10046afii10052afii10087afii10050afii10145afii10057afii10059afii10146afii10088afii10101afii10054afii10058Rholenisafii10025afii10099afii10068afii10035afii10048afii10089afii10105afii10085afii10020afii10077afii10106afii10019afii10076afii10110afii10100afii10090afii10028afii10095afii10147afii10066afii10098afii10082afii10061afii10103afii10102afii10083afii10027afii10072afii10039afii61352afii10069afii10094afii10038afii10034afii10148afii10032afii10194afii10033afii10075afii10017afii10081afii10056afii10084afii10044afii10030afii10051afii10047afii10018afii10080afii10042afii10071afii10029afii10062afii10065afii10097T_h.commaaccentafii10096afii10079afii10091afii10093afii10064afii10043afii10092uni2215uni021Bafii10073afii10067uni00A0uni021Aafii10086afii10055uni0394uni03BCuni03A9uni00ADCopyright 2000 Adobe Systems Incorporated. All Rights Reserved. U.S. Patent Des. 337,604.Minion is either a registered trademark or a trademark of Adobe Systems Incorporated in the United States and/or other countries.Minion Pro RegularMinion Pro% i WZ5:`v22> % I
/
2
I
o
#3p~U
D
e
!o#]emE %<Jeov~EMfjtFp|,S-AZ0=DK +^&7NQy(/S_dl 5Rk$=Valsz"'-@T_gos{ ) . > N ^ d n v ~ !!!!'!3!?!H!Q!Z!]!c!i!n!s!x!!!!!!!!!!!!!"""#"'"3"?"K"W"c"k"s"{""""""""""""""c&oEr^7 JB@H *W2c~sp&m!1= 4:$kYyywRvzwrZnon?˘iNUddLoLݪ
~}}vywS6vO(Zp^TrǕ؍8x`?NYwUVYWE}zyMhummR~Kfowx}|txcBzuyBpOwTxql[LPҩy}~Bxxhzqlc#T0@9
5/j,X^M8Uruuoquvqiff{bE<H8XUo^bb_rMG'Н=[W}yQSSۚ$P|TzTyT'
ajqyzx||rrpwttozpj`lWHrʥaiqyo
|rqpxt@tpyqjalVHr]yt/m'mDx]pIsn8AgmxpQAz4wv~s}~vstzf|oęgfeoszvwzxu$wny|YgJO-ʆea]>9+ZhchAB_\?#^|m[5v-<<[FL LHHq˂~XxAo4uFabfqaf%f+rrs}ǔcqW "* ڟŇՊvx|po~}wUJN<0o-כtzr[ {"!coч~^o]/6'orsBp0ZlZqRoGt{_Fpq|iiMkTratap`DabuvCICpAϦ{~{lpˇBDDpӐ qoكtYoNU)gI_Z`yӔodžF/INlw71oC
ŸԱȗГnoՆ3$811xrdcQD:0] ;hJjp~djmplXhZfYxnmmyf^#MR:AgszvT]jjZ?_ynZQ{sNHyZdƨ]O틯֯}ޣDyZ{kvumofFMk_VYЄ#ms^@L A_!Z Z|蒯}~rqyg|usqrwgmazԬqbfZBoل5|%69o<3oZMZJuׇ3c T{ddmvrjY_VpŇkrkGpφ}8Fgsmy]pWSy/OBR7WXjfeolw}v84o~}xUGP~72pC
~㿊IK
NϪb98IPq
`y[~XsłI\FL
ދ.R۲vhl_@oۅ8(85oq͗ƫ>(3XOG7]_\i^%"Ba:Jy.}eu}|wzq]is|~ґϐuCDDEp
ؑ~P|xhcMp^},
qkuGuzwv~s}~ust}e{nęgfR5BcH
蠓`
i
`c
v
y
蠚}xsnyvrpyh&T~Y|S|Q4xrqxvrpyhrqVVrm