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Klinger, Christoph J.; Dengler, Berrett; Bauer, Thomas; Müller, Ralf S. (2018): Erfolgreiche Behandlung einer nekrotisierenden, multiresistenten bakteriellen Pyodermie bei einem Python mittels Kaltplasmatherapie. In: Tierärztliche Praxis Ausgabe Kleintiere Heimtiere, Vol. 46, No. 1: pp. 43-48
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Abstract

A 4-year-old ball python was presented 3 weeks after multiple bite wounds from a prey rat with large skin lesions, a concurrent deep bacterial pyoderma and clinical signs for septicemia, including neurological symptoms. Affected tissue separated from the underlying muscular layer revealing parts of the muscles. Clinical examination and cytology was consistent with bacterial pyoderma;septicemia was an additional tentative clinical diagnosis. Empirical lincomycin and marbofloxacin (bacterial culture revealed a multi-resistant Stenotrophomonas maltophilia susceptible to fluoroquinolones) treatment improved the patient's general condition but skin wounds deteriorated to multi-focal eschars with intracellular rods. Further diagnostics were limited for financial reasons, euthanasia was considered. Cold atmospheric pressure plasma (CAPP) therapy was performed six times in 4 weeks. Within 1 week, inflammatory symptoms resolved. Re-epithelialization was completed few weeks later. In the following year, the snake sloughed three times without any signs of dysecdysis. CAPP therapy may offer a viable treatment option for bacterial (especially multi-resistant) pyoderma and necrotizing dermatitis in snakes.