%PDF-1.6
%
1 0 obj
<>
endobj
2 0 obj
<>stream
Silke Bergeler, Erwin Frey
Regulation of Pom cluster dynamics in Myxococcus xanthus
www.ploscompbiol.org
www.ploscompbiol.org
endstream
endobj
3 0 obj
<>/XObject<>>>/CropBox[0 0 612 792]/MediaBox[0 0 612 792]/Parent 13 0 R/Annots 14 0 R/Contents 15 0 R/TrimBox[0 0 612 792]>>
endobj
14 0 obj
[16 0 R 17 0 R 18 0 R 19 0 R 20 0 R 21 0 R 22 0 R 23 0 R 24 0 R 25 0 R 26 0 R 27 0 R 28 0 R 29 0 R 30 0 R 31 0 R 32 0 R 33 0 R 34 0 R 35 0 R 36 0 R]
endobj
16 0 obj
<>/Border[0 0 0]/Dest(Rpcbi.1006358.ref001)>>
endobj
17 0 obj
<>/Border[0 0 0]/Dest(Rpcbi.1006358.ref003)>>
endobj
18 0 obj
<>/Border[0 0 0]/Dest(Rpcbi.1006358.ref004)>>
endobj
19 0 obj
<>/Border[0 0 0]/Dest(Rpcbi.1006358.ref006)>>
endobj
20 0 obj
<>/Border[0 0 0]/Dest(Rpcbi.1006358.ref003)>>
endobj
21 0 obj
<>/Border[0 0 0]/Dest(Rpcbi.1006358.ref005)>>
endobj
22 0 obj
<>/Border[0 0 0]/Dest(Rpcbi.1006358.ref004)>>
endobj
23 0 obj
<>/Border[0 0 0]/Dest(Rpcbi.1006358.ref005)>>
endobj
24 0 obj
<>/Border[0 0 0]/Dest(Rpcbi.1006358.ref007)>>
endobj
25 0 obj
<>/Border[0 0 0]/Dest(Rpcbi.1006358.ref021)>>
endobj
26 0 obj
<>/Border[0 0 0]/Dest(Rpcbi.1006358.ref022)>>
endobj
27 0 obj
<>/Border[0 0 0]/Dest(Rpcbi.1006358.ref005)>>
endobj
28 0 obj
<>/Border[0 0 0]/Dest(Rpcbi.1006358.ref022)>>
endobj
29 0 obj
<>/Border[0 0 0]/Dest(Rpcbi.1006358.ref023)>>
endobj
30 0 obj
<>/Border[0 0 0]/Dest(Rpcbi.1006358.ref024)>>
endobj
31 0 obj
<>/Border[0 0 0]/Dest(Rpcbi.1006358.ref026)>>
endobj
32 0 obj
<>/Border[0 0 0]/Dest(Rpcbi.1006358.ref027)>>
endobj
33 0 obj
<>/Border[0 0 0]/Dest(Rpcbi.1006358.ref029)>>
endobj
34 0 obj
<>/Border[0 0 0]/Dest(Rpcbi.1006358.ref030)>>
endobj
35 0 obj
<>/Border[0 0 0]/Dest(Rpcbi.1006358.ref032)>>
endobj
36 0 obj
<>/Border[0 0 0]/A 37 0 R>>
endobj
37 0 obj
<>
endobj
15 0 obj
[38 0 R 39 0 R 40 0 R 41 0 R 42 0 R 43 0 R 44 0 R 45 0 R 46 0 R 47 0 R 48 0 R 49 0 R 50 0 R 51 0 R 52 0 R 53 0 R 54 0 R]
endobj
38 0 obj
<>stream
q
0.955 g
0 w
199.9998 713.9999 m
575.9997 713.9999 l
575.9997 611.0002 l
199.9998 611.0002 l
f*
0.83 0.64 0.02 0 k
550.9417 471.9118 m
555.7039 471.9118 l
h
f*
560.863 471.9118 m
565.6252 471.9118 l
h
f*
222.1228 432.9071 m
226.885 432.9071 l
h
f*
232.0441 432.9071 m
236.8063 432.9071 l
h
f*
543.8551 432.9071 m
548.6173 432.9071 l
h
f*
255.1181 367.937 m
259.8803 367.937 l
h
f*
483.4772 328.9323 m
488.2394 328.9323 l
h
f*
492.7181 328.9323 m
497.4803 328.9323 l
h
f*
284.485 302.9102 m
289.2472 302.9102 l
h
f*
294.4063 302.9102 m
303.9307 302.9102 l
h
f*
520.0441 237.9402 m
529.5685 237.9402 l
h
f*
430.8094 224.9008 m
435.5717 224.9008 l
h
f*
460.0063 198.9354 m
469.5307 198.9354 l
h
f*
473.9528 198.9354 m
483.4772 198.9354 l
h
f*
559.0488 120.926 m
568.7433 120.926 l
h
f*
200.0126 107.9433 m
209.7071 107.9433 l
h
f*
557.8583 94.9039 m
567.5528 94.9039 l
h
f*
200.0126 81.9213 m
209.7071 81.9213 l
h
f*
460.6866 81.9213 m
470.3811 81.9213 l
h
f*
475.6535 81.9213 m
485.348 81.9213 l
h
f*
0 g
1 j
1 J
10 0 0 10 209.9905 696.9826 cm
BT
/F7 1 Tf
1 TL
-0.004 Tc
0 0 Td
(midcell.)Tj
3.4015 0 Td
(We)Tj
1.6101 0 Td
(are)Tj
1.4456 0 Td
(interested)Tj
4.1613 0 Td
(in)Tj
1.0374 0 Td
(the)Tj
1.4684 0 Td
(question)Tj
3.6623 0 Td
(how)Tj
1.9389 0 Td
(the)Tj
1.4683 0 Td
(cluster)Tj
2.8744 0 Td
(trajectories)Tj
4.6544 0 Td
(change)Tj
3.0444 0 Td
(when)Tj
2.4038 0 Td
(the)Tj
-33.1708 -1.2982 Td
(PomZ)Tj
2.7099 0 Td
(dynamics)Tj
4.0535 0 Td
(is)Tj
0.8504 0 Td
(varied.)Tj
2.9196 0 Td
(To)Tj
1.338 0 Td
(address)Tj
3.2258 0 Td
(this)Tj
1.6781 0 Td
(question)Tj
3.6566 0 Td
(we)Tj
1.3267 0 Td
(investigate)Tj
4.4617 0 Td
(a)Tj
0.6576 0 Td
(previously)Tj
4.3483 0 Td
(developed)Tj
-31.2262 -1.2983 Td
(mathematical)Tj
5.6465 0 Td
(model)Tj
2.7439 0 Td
(that)Tj
1.7802 0 Td
(incorporates)Tj
5.2497 0 Td
(the)Tj
1.4684 0 Td
(nucleoid,)Tj
3.9174 0 Td
(the)Tj
1.4684 0 Td
(cluster)Tj
2.8743 0 Td
(and)Tj
1.7291 0 Td
(PomZ.)Tj
2.931 0 Td
(We)Tj
1.6101 0 Td
(simulated)Tj
-31.419 -1.3039 Td
(the)Tj
1.4683 0 Td
(cluster)Tj
2.8743 0 Td
(trajectories)Tj
4.6545 0 Td
(for)Tj
1.3889 0 Td
(different)Tj
3.651 0 Td
(model)Tj
2.7496 0 Td
(parameters,)Tj
4.8983 0 Td
(such)Tj
2.0579 0 Td
(as)Tj
1.0148 0 Td
(different)Tj
3.6567 0 Td
(diffusion)Tj
3.804 0 Td
(con-)Tj
-32.2183 -1.2983 Td
(stants)Tj
2.5228 0 Td
(of)Tj
1.0148 0 Td
(PomZ)Tj
2.7042 0 Td
(on)Tj
1.2756 0 Td
(the)Tj
1.4683 0 Td
(nucleoid.)Tj
3.9175 0 Td
(Interestingly,)Tj
5.4935 0 Td
(when)Tj
2.4037 0 Td
(PomZ)Tj
2.7043 0 Td
(diffuses)Tj
3.2655 0 Td
(slowly)Tj
2.7212 0 Td
(on)Tj
1.2756 0 Td
(the)Tj
1.4683 0 Td
(nucle-)Tj
-32.2353 -1.2982 Td
(oid,)Tj
1.7461 0 Td
(we)Tj
1.3323 0 Td
(observed)Tj
3.7927 0 Td
(oscillatory)Tj
4.337 0 Td
(cluster)Tj
2.8686 0 Td
(movements)Tj
4.8756 0 Td
(around)Tj
3.1407 0 Td
(midcell.)Tj
3.3959 0 Td
(Our)Tj
1.8652 0 Td
(results)Tj
2.812 0 Td
(provide)Tj
-30.1661 -1.3039 Td
(general)Tj
3.135 0 Td
(insights)Tj
3.3166 0 Td
(into)Tj
1.8368 0 Td
(intracellular)Tj
5.0626 0 Td
(positioning)Tj
4.7736 0 Td
(of)Tj
1.0148 0 Td
(proteins.)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 568.0062 cm
BT
/F3 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(Introduction)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 550.9984 cm
BT
/F7 1 Tf
1 TL
-0.004 Tc
0 0 Td
(The)Tj
1.7801 0 Td
(formation)Tj
4.2633 0 Td
(of)Tj
1.0148 0 Td
(protein)Tj
3.1521 0 Td
(patterns)Tj
3.4696 0 Td
(and)Tj
1.7348 0 Td
(the)Tj
1.4683 0 Td
(intracellular)Tj
5.057 0 Td
(positioning)Tj
4.7735 0 Td
(of)Tj
1.0148 0 Td
(proteins)Tj
3.5149 0 Td
(is)Tj
0.8504 0 Td
(a)Tj
0.652 0 Td
(major)Tj
2.6078 0 Td
(pre-)Tj
-35.3534 -1.2982 Td
(requisite)Tj
3.668 0 Td
(for)Tj
1.3833 0 Td
(many)Tj
2.4774 0 Td
(important)Tj
4.2803 0 Td
(processes)Tj
3.9685 0 Td
(in)Tj
1.0375 0 Td
(bacterial)Tj
3.6226 0 Td
(cells,)Tj
2.1487 0 Td
(such)Tj
2.0579 0 Td
(as)Tj
1.0148 0 Td
(cell)Tj
1.559 0 Td
(division.)Tj
3.6454 0 Td
(In)Tj
1.1112 0 Td
(order)Tj
2.4207 0 Td
(to)Tj
-34.3953 -1.3039 Td
(maintain)Tj
3.838 0 Td
(the)Tj
1.4684 0 Td
(genetic)Tj
3.067 0 Td
(content)Tj
3.2712 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4683 0 Td
(bacterial)Tj
3.6227 0 Td
(cell,)Tj
1.7858 0 Td
(the)Tj
1.4683 0 Td
(chromosome)Tj
5.4879 0 Td
(\(nucleoid\))Tj
4.371 0 Td
(is)Tj
0.8504 0 Td
(duplicated)Tj
-31.7138 -1.2983 Td
(during)Tj
2.9253 0 Td
(the)Tj
1.4683 0 Td
(cell)Tj
1.5647 0 Td
(cycle)Tj
2.1884 0 Td
(and)Tj
1.7291 0 Td
(must)Tj
2.228 0 Td
(be)Tj
1.1509 0 Td
(segregated)Tj
4.4107 0 Td
(into)Tj
1.8425 0 Td
(the)Tj
1.4683 0 Td
(two)Tj
1.7121 0 Td
(cell)Tj
1.5591 0 Td
(halves)Tj
2.6645 0 Td
(prior)Tj
2.2564 0 Td
(to)Tj
1.0261 0 Td
(cell)Tj
1.5591 0 Td
(division.)Tj
3.6453 0 Td
(The)Tj
-35.3988 -1.2983 Td
(future)Tj
2.6532 0 Td
(division)Tj
3.4242 0 Td
(site)Tj
1.5704 0 Td
(is)Tj
0.8447 0 Td
(defined)Tj
3.2258 0 Td
(by)Tj
1.1849 0 Td
(the)Tj
1.4683 0 Td
(FtsZ)Tj
2.0069 0 Td
(ring,)Tj
2.0977 0 Td
(which)Tj
2.6475 0 Td
(forms)Tj
2.5682 0 Td
(at)Tj
0.9524 0 Td
(midcell)Tj
3.1748 0 Td
(and)Tj
1.7291 0 Td
(recruits)Tj
3.2655 0 Td
(the)Tj
1.4683 0 Td
(cytoki-)Tj
-34.2819 -1.3039 Td
(netic)Tj
2.1769 0 Td
(machinery.)Tj
4.7169 0 Td
(Interestingly,)Tj
5.4935 0 Td
(FtsZ)Tj
2.0069 0 Td
(is)Tj
0.8504 0 Td
(highly)Tj
2.7099 0 Td
(conserved)Tj
4.2576 0 Td
(in)Tj
1.0375 0 Td
(bacteria,)Tj
3.5999 0 Td
(while)Tj
2.3698 0 Td
(the)Tj
1.474 0 Td
(protein)Tj
3.1521 0 Td
(systems)Tj
-33.8454 -1.2982 Td
(responsible)Tj
4.7508 0 Td
(for)Tj
1.389 0 Td
(the)Tj
1.4683 0 Td
(positioning)Tj
4.7735 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4683 0 Td
(FtsZ)Tj
2.007 0 Td
(ring,)Tj
2.0976 0 Td
(and)Tj
1.7348 0 Td
(with)Tj
1.9955 0 Td
(it)Tj
0.7824 0 Td
(the)Tj
1.474 0 Td
(cell)Tj
1.5591 0 Td
(division)Tj
3.4185 0 Td
(site,)Tj
1.7972 0 Td
(are)Tj
1.4456 0 Td
(not)Tj
1.5761 0 Td
([)Tj
0.83 0.64 0.02 0 k
(1)Tj
0 g
()Tj
0.83 0.64 0.02 0 k
(3)Tj
0 g
(].)Tj
-33.5563 -1.2983 Td
(Recently,)Tj
3.8891 0 Td
(Schumacher)Tj
5.1703 0 Td
(et)Tj
0.9468 0 Td
(al.)Tj
1.1225 0 Td
(identified)Tj
4.0592 0 Td
(a)Tj
0.652 0 Td
(set)Tj
1.3039 0 Td
(of)Tj
1.0148 0 Td
(proteins,)Tj
3.7417 0 Td
(called)Tj
2.5228 0 Td
(PomX,)Tj
2.982 0 Td
(PomY)Tj
2.7383 0 Td
(and)Tj
1.7291 0 Td
(PomZ,)Tj
2.931 0 Td
(in)Tj
/F8 1 Tf
-35.9997 -1.2983 Td
[()47(\n)-4()4()7()4()7()1()-4( )]TJ
4.8925 0 Td
[()-4()16()22()10()18()-4( )]TJ
/F7 1 Tf
3.3619 0 Td
(cells)Tj
1.9219 0 Td
(that)Tj
1.7744 0 Td
(are)Tj
1.4514 0 Td
(important)Tj
4.2803 0 Td
(for)Tj
1.3889 0 Td
(midcell)Tj
3.1691 0 Td
(localization)Tj
4.8132 0 Td
(and)Tj
1.7292 0 Td
(formation)Tj
4.2632 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4684 0 Td
(FtsZ)Tj
-35.5292 -1.3039 Td
(ring)Tj
1.8708 0 Td
([)Tj
0.83 0.64 0.02 0 k
(4)Tj
0 g
()Tj
0.83 0.64 0.02 0 k
(6)Tj
0 g
(].)Tj
2.5965 0 Td
(PomZ)Tj
2.7043 0 Td
(is)Tj
0.8503 0 Td
(an)Tj
1.2019 0 Td
(ATPase,)Tj
3.515 0 Td
(which)Tj
2.6532 0 Td
(belongs)Tj
3.2768 0 Td
(to)Tj
1.0261 0 Td
(the)Tj
1.4684 0 Td
(family)Tj
2.7269 0 Td
(of)Tj
1.0148 0 Td
(ParA)Tj
2.2734 0 Td
(/)Tj
0.5499 0 Td
(MinD)Tj
2.6645 0 Td
(ATPases)Tj
3.651 0 Td
([)Tj
0.83 0.64 0.02 0 k
(3)Tj
0 g
(].)Tj
1.5988 0 Td
(It)Tj
-35.6426 -1.2983 Td
(binds)Tj
2.4321 0 Td
(non-specifically)Tj
6.5253 0 Td
(to)Tj
1.0261 0 Td
(DNA)Tj
2.3754 0 Td
(in)Tj
1.0375 0 Td
(its)Tj
1.1452 0 Td
(dimeric,)Tj
3.5433 0 Td
(ATP-bound)Tj
5.0456 0 Td
(state,)Tj
2.2564 0 Td
(and)Tj
1.7348 0 Td
(its)Tj
1.1452 0 Td
(activity)Tj
3.118 0 Td
(is)Tj
0.8448 0 Td
(stimulated)Tj
-32.2297 -1.2982 Td
(by)Tj
1.1792 0 Td
(interactions)Tj
4.9719 0 Td
(with)Tj
1.9956 0 Td
(PomX,)Tj
2.982 0 Td
(PomY)Tj
2.7382 0 Td
(and)Tj
1.7292 0 Td
(DNA.)Tj
2.6022 0 Td
(PomX)Tj
2.7609 0 Td
(and)Tj
1.7291 0 Td
(PomY)Tj
2.7383 0 Td
(form)Tj
2.2053 0 Td
(a)Tj
0.652 0 Td
(single)Tj
2.5341 0 Td
(cluster,)Tj
3.0954 0 Td
(which)Tj
2.6532 0 Td
(is)Tj
-36.5666 -1.3039 Td
(tethered)Tj
3.5149 0 Td
(to)Tj
1.0205 0 Td
(the)Tj
1.474 0 Td
(nucleoid)Tj
3.6906 0 Td
(via)Tj
1.372 0 Td
(PomZ)Tj
2.7099 0 Td
(dimers)Tj
2.9877 0 Td
(bound)Tj
2.8403 0 Td
(to)Tj
1.0261 0 Td
(the)Tj
1.4684 0 Td
(chromosome.)Tj
5.7146 0 Td
(Starting)Tj
3.3789 0 Td
(from)Tj
2.2053 0 Td
(an)Tj
1.2019 0 Td
(off-)Tj
-34.6051 -1.2983 Td
(center)Tj
2.7099 0 Td
(position)Tj
3.4922 0 Td
(near)Tj
1.9956 0 Td
(one)Tj
1.7008 0 Td
(nucleoid)Tj
3.6907 0 Td
(pole,)Tj
2.1373 0 Td
(the)Tj
1.4683 0 Td
(cluster)Tj
2.8743 0 Td
(moves)Tj
2.7836 0 Td
(towards)Tj
3.4072 0 Td
(midnucleoid,)Tj
5.5276 0 Td
(coinciding)Tj
-31.7875 -1.2983 Td
(with)Tj
1.9955 0 Td
(midcell)Tj
3.1748 0 Td
([)Tj
0.83 0.64 0.02 0 k
(5)Tj
0 g
(].)Tj
1.5987 0 Td
(When)Tj
2.6873 0 Td
(the)Tj
1.4683 0 Td
(cluster)Tj
2.8743 0 Td
(has)Tj
1.5421 0 Td
(reached)Tj
3.3505 0 Td
(midcell,)Tj
3.4015 0 Td
(the)Tj
1.4684 0 Td
(FtsZ)Tj
2.0069 0 Td
(ring)Tj
1.8708 0 Td
(forms)Tj
2.5682 0 Td
(there)Tj
2.2621 0 Td
(and)Tj
1.7347 0 Td
(the)Tj
1.4684 0 Td
(cell)Tj
-35.4725 -1.3039 Td
(divides.)Tj
3.2711 0 Td
(During)Tj
3.1408 0 Td
(cell)Tj
1.559 0 Td
(division,)Tj
3.6454 0 Td
(the)Tj
1.4683 0 Td
(cluster)Tj
2.8686 0 Td
(splits)Tj
2.2734 0 Td
(into)Tj
1.8425 0 Td
(two)Tj
1.7065 0 Td
(halves,)Tj
2.8913 0 Td
(such)Tj
2.0636 0 Td
(that)Tj
1.7745 0 Td
(each)Tj
2.0296 0 Td
(half)Tj
1.7177 0 Td
(is)Tj
0.8504 0 Td
(located)Tj
3.0784 0 Td
(at)Tj
-36.1811 -1.2982 Td
(one)Tj
1.6951 0 Td
(pole)Tj
1.9162 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4683 0 Td
(nucleoids)Tj
4.0535 0 Td
(in)Tj
1.0375 0 Td
(the)Tj
1.4683 0 Td
(daughter)Tj
3.7928 0 Td
(cells,)Tj
2.1486 0 Td
(and)Tj
1.7291 0 Td
(the)Tj
1.4684 0 Td
(same)Tj
2.262 0 Td
(cycle)Tj
2.1883 0 Td
(repeats.)Tj
3.2769 0 Td
(Notably,)Tj
3.6283 0 Td
(the)Tj
1.4683 0 Td
(Pom)Tj
-34.6164 -1.2983 Td
(proteins)Tj
3.5149 0 Td
(localize)Tj
3.1804 0 Td
(to)Tj
1.0205 0 Td
(midcell)Tj
3.1748 0 Td
(before)Tj
2.7439 0 Td
(FtsZ)Tj
2.0069 0 Td
(and)Tj
1.7291 0 Td
(also)Tj
1.7689 0 Td
(in)Tj
1.0374 0 Td
(the)Tj
1.4684 0 Td
(absence)Tj
3.3392 0 Td
(of)Tj
1.0148 0 Td
(FtsZ)Tj
2.0069 0 Td
([)Tj
0.83 0.64 0.02 0 k
(4)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
1.2642 0 Td
(5)Tj
0 g
(].)Tj
-28.0741 -1.2983 Td
(The)Tj
1.7858 0 Td
(mechanism)Tj
4.8415 0 Td
(underlying)Tj
4.6035 0 Td
(midcell)Tj
3.1747 0 Td
(localization)Tj
4.8132 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4684 0 Td
(FtsZ)Tj
2.0069 0 Td
(ring)Tj
1.8708 0 Td
(is)Tj
0.8504 0 Td
(well)Tj
1.8199 0 Td
(understood)Tj
4.8188 0 Td
(in)Tj
/F8 1 Tf
-34.2649 -1.3039 Td
[(\r)-4( )-3()13()6()2()-9()4()13()18()4()]TJ
4.6261 0 Td
[()7()10()12()]TJ
/F7 1 Tf
1.559 0 Td
(cells)Tj
1.9219 0 Td
([)Tj
0.83 0.64 0.02 0 k
(7)Tj
0 g
()Tj
0.83 0.64 0.02 0 k
(21)Tj
0 g
(].)Tj
3.0671 0 Td
(Here,)Tj
2.4321 0 Td
(Min)Tj
1.9275 0 Td
(proteins)Tj
3.5149 0 Td
(\(MinC,)Tj
3.1578 0 Td
(MinD)Tj
2.6646 0 Td
(and)Tj
1.7291 0 Td
(MinE\))Tj
2.8403 0 Td
(guide)Tj
2.4321 0 Td
(the)Tj
1.4683 0 Td
(formation)Tj
-33.3408 -1.2983 Td
(of)Tj
1.0147 0 Td
(the)Tj
1.4684 0 Td
(FtsZ)Tj
2.0069 0 Td
(ring)Tj
1.8709 0 Td
(at)Tj
0.9524 0 Td
(midcell.)Tj
3.4015 0 Td
(Importantly,)Tj
5.2838 0 Td
(the)Tj
1.4683 0 Td
(system)Tj
2.9367 0 Td
(for)Tj
1.389 0 Td
(midcell)Tj
3.1691 0 Td
(localization)Tj
4.8132 0 Td
(in)Tj
/F8 1 Tf
1.0375 0 Td
[(\r)]TJ
0.9921 0 Td
[()7()10()12()]TJ
/F7 1 Tf
1.559 0 Td
(and)Tj
/F8 1 Tf
1.7291 0 Td
[()]TJ
-35.0926 -1.2982 Td
[()-4()16()22()10()18()-4( )]TJ
/F7 1 Tf
3.3618 0 Td
(differ)Tj
2.3868 0 Td
(substantially,)Tj
5.4255 0 Td
(even)Tj
2.0692 0 Td
(though)Tj
3.0784 0 Td
(both)Tj
2.058 0 Td
(systems)Tj
3.2995 0 Td
(contain)Tj
3.2485 0 Td
(an)Tj
1.2018 0 Td
(ATPase)Tj
3.2939 0 Td
(\(PomZ)Tj
3.0444 0 Td
(and)Tj
1.7291 0 Td
(MinD,)Tj
-34.1969 -1.3039 Td
(respectively\))Tj
5.2213 0 Td
(and)Tj
1.7348 0 Td
(perform)Tj
3.515 0 Td
(the)Tj
1.4683 0 Td
(same)Tj
2.262 0 Td
(task)Tj
1.8085 0 Td
(in)Tj
1.0375 0 Td
(the)Tj
1.4683 0 Td
(cell,)Tj
1.7859 0 Td
(i.e.)Tj
1.3606 0 Td
(midcell)Tj
3.1748 0 Td
(sensing.)Tj
3.4185 0 Td
(First,)Tj
2.2677 0 Td
(the)Tj
1.474 0 Td
(scaffold)Tj
3.2939 0 Td
(to)Tj
-35.2911 -1.2983 Td
(which)Tj
2.6475 0 Td
(the)Tj
1.4683 0 Td
(ATP-bound)Tj
5.0457 0 Td
(ATPase)Tj
3.2938 0 Td
(binds)Tj
2.4321 0 Td
(is)Tj
0.8447 0 Td
(different:)Tj
3.8835 0 Td
(MinD)Tj
2.6645 0 Td
(binds)Tj
2.4321 0 Td
(to)Tj
1.0262 0 Td
(the)Tj
1.4683 0 Td
(cell)Tj
1.5591 0 Td
(membrane)Tj
4.5637 0 Td
(and)Tj
1.7348 0 Td
(PomZ)Tj
-35.0643 -1.2983 Td
(to)Tj
1.0261 0 Td
(the)Tj
1.4683 0 Td
(bacterial)Tj
3.6227 0 Td
(nucleoid)Tj
3.6907 0 Td
(in)Tj
1.0374 0 Td
(the)Tj
1.4684 0 Td
(cytoplasm.)Tj
4.507 0 Td
(Second,)Tj
3.3506 0 Td
(MinD-bound)Tj
5.6352 0 Td
(MinC)Tj
2.5909 0 Td
(inhibits)Tj
3.2654 0 Td
([)Tj
0.83 0.64 0.02 0 k
(22)Tj
0 g
(],)Tj
2.075 0 Td
(whereas)Tj
-33.7377 -1.3039 Td
(the)Tj
1.4683 0 Td
(Pom)Tj
2.1033 0 Td
(cluster)Tj
2.8743 0 Td
(promotes)Tj
4.0252 0 Td
(FtsZ)Tj
2.0069 0 Td
(ring)Tj
1.8708 0 Td
(formation)Tj
4.2633 0 Td
(at)Tj
0.9525 0 Td
(midcell)Tj
3.1747 0 Td
([)Tj
0.83 0.64 0.02 0 k
(5)Tj
0 g
(].)Tj
1.5988 0 Td
(Finally,)Tj
3.1691 0 Td
(the)Tj
1.4683 0 Td
(observed)Tj
3.7984 0 Td
(protein)Tj
3.1521 0 Td
(pat-)Tj
-35.926 -1.2983 Td
(terns)Tj
2.2223 0 Td
(differ:)Tj
2.6079 0 Td
(the)Tj
1.474 0 Td
(Pom)Tj
2.1033 0 Td
(proteins)Tj
3.5149 0 Td
(colocalize)Tj
4.1102 0 Td
(in)Tj
1.0375 0 Td
(a)Tj
0.6519 0 Td
(cluster)Tj
2.8744 0 Td
(that)Tj
1.7744 0 Td
(moves)Tj
2.7893 0 Td
(towards)Tj
3.4016 0 Td
(midcell,)Tj
3.4015 0 Td
(while)Tj
2.3641 0 Td
(the)Tj
1.474 0 Td
(Min)Tj
-35.8013 -1.2982 Td
(proteins,)Tj
3.736 0 Td
(which)Tj
2.6532 0 Td
(do)Tj
1.2529 0 Td
(not)Tj
1.5761 0 Td
(form)Tj
2.2053 0 Td
(a)Tj
0.652 0 Td
(cluster,)Tj
3.0954 0 Td
(oscillate)Tj
3.4299 0 Td
(from)Tj
2.2053 0 Td
(pole)Tj
1.9162 0 Td
(to)Tj
1.0205 0 Td
(pole)Tj
1.9162 0 Td
([)Tj
0.83 0.64 0.02 0 k
(22)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
1.7348 0 Td
(23)Tj
0 g
(].)Tj
0.005 Tc
-26.1976 -1.3039 Td
(Conversely,)Tj
5.0002 0 Td
(the)Tj
1.4967 0 Td
(Pom)Tj
2.1317 0 Td
(system)Tj
2.9933 0 Td
(is)Tj
0.8674 0 Td
(mechanistically)Tj
6.531 0 Td
(more)Tj
2.3754 0 Td
(similar)Tj
3.0501 0 Td
(to)Tj
1.0431 0 Td
(plasmid)Tj
3.4526 0 Td
(and)Tj
1.7575 0 Td
(chromosome)Tj
-31.8952 -1.2983 Td
(segregation)Tj
4.8812 0 Td
(systems)Tj
3.3618 0 Td
(that)Tj
1.8142 0 Td
(involve)Tj
3.1861 0 Td
(a)Tj
0.6633 0 Td
(ParAB)Tj
/F8 1 Tf
[()]TJ
/F7 1 Tf
3.3562 0 Td
(system.)Tj
3.2258 0 Td
(Like)Tj
1.9843 0 Td
(the)Tj
1.4967 0 Td
(Pom)Tj
2.1316 0 Td
(system,)Tj
3.2258 0 Td
(plasmid)Tj
3.4526 0 Td
(and)Tj
1.7575 0 Td
(chro-)Tj
-34.5371 -1.2983 Td
(mosome)Tj
3.7076 0 Td
(segregation)Tj
4.8869 0 Td
(systems)Tj
3.3619 0 Td
(make)Tj
2.4265 0 Td
(use)Tj
1.559 0 Td
(of)Tj
1.0375 0 Td
(an)Tj
1.2189 0 Td
(ATPase)Tj
3.3448 0 Td
(that)Tj
1.8142 0 Td
(shuttles)Tj
3.3392 0 Td
(one)Tj
1.7234 0 Td
(or)Tj
1.1169 0 Td
(several)Tj
2.999 0 Td
(cargoes)Tj
-32.5358 -1.2982 Td
(\(such)Tj
2.4434 0 Td
(as)Tj
1.0318 0 Td
(a)Tj
0.6633 0 Td
(plasmid,)Tj
3.6907 0 Td
(a)Tj
0.6633 0 Td
(partition)Tj
3.8097 0 Td
(complex)Tj
3.6851 0 Td
(or)Tj
1.1168 0 Td
(a)Tj
0.6633 0 Td
(protein)Tj
3.2145 0 Td
(cluster\))Tj
3.2825 0 Td
(along)Tj
2.4661 0 Td
(the)Tj
1.4967 0 Td
(nucleoid.)Tj
3.9968 0 Td
(To)Tj
1.3606 0 Td
(ensure)Tj
-33.5846 -1.3039 Td
(the)Tj
1.4966 0 Td
(equal)Tj
2.4038 0 Td
(distribution)Tj
5.074 0 Td
(of)Tj
1.0318 0 Td
(low-copy)Tj
3.9855 0 Td
(number)Tj
3.4696 0 Td
(plasmids)Tj
3.8267 0 Td
(to)Tj
1.0431 0 Td
(the)Tj
1.4967 0 Td
(daughter)Tj
3.8665 0 Td
(cells,)Tj
2.1996 0 Td
(they)Tj
1.9616 0 Td
(are)Tj
1.474 0 Td
(tethered)Tj
-33.3295 -1.2983 Td
(to)Tj
1.0431 0 Td
(the)Tj
1.4967 0 Td
(nucleoid)Tj
3.7644 0 Td
(and)Tj
1.7574 0 Td
(positioned)Tj
4.5298 0 Td
(at)Tj
0.9694 0 Td
(equal)Tj
2.4038 0 Td
(distances)Tj
3.9458 0 Td
(along)Tj
2.4661 0 Td
(the)Tj
1.4967 0 Td
(nucleoid)Tj
3.7644 0 Td
(by)Tj
1.2019 0 Td
(ParAB)Tj
/F8 1 Tf
[()]TJ
/F7 1 Tf
3.3562 0 Td
(systems)Tj
3.3618 0 Td
([)Tj
0.83 0.64 0.02 0 k
(24)Tj
0 g
()Tj
0.83 0.64 0.02 0 k
-35.5575 -1.2983 Td
(26)Tj
0 g
(].)Tj
1.7688 0 Td
(A)Tj
0.9184 0 Td
(ParAB)Tj
/F8 1 Tf
[()]TJ
/F7 1 Tf
3.3562 0 Td
(system)Tj
2.9877 0 Td
(consists)Tj
3.4242 0 Td
(of)Tj
1.0318 0 Td
(the)Tj
1.4967 0 Td
(proteins)Tj
3.583 0 Td
(ParA)Tj
2.3073 0 Td
(and)Tj
1.7575 0 Td
(ParB,)Tj
2.4321 0 Td
(and)Tj
1.7575 0 Td
(a)Tj
0.6633 0 Td
(DNA)Tj
2.4038 0 Td
(sequence,)Tj
/F8 1 Tf
4.1612 0 Td
[()4()16()]TJ
/F7 1 Tf
(.)Tj
-34.0495 -1.3039 Td
(ParA)Tj
2.3017 0 Td
(proteins)Tj
3.5886 0 Td
(are)Tj
1.474 0 Td
(ATPases,)Tj
3.9515 0 Td
(which)Tj
2.6929 0 Td
(bind)Tj
2.1089 0 Td
(non-specifically)Tj
6.6671 0 Td
(to)Tj
1.0431 0 Td
(DNA)Tj
2.4038 0 Td
(as)Tj
1.0375 0 Td
(ATP-bound)Tj
5.1193 0 Td
(dimers)Tj
3.0444 0 Td
([)Tj
0.83 0.64 0.02 0 k
(27)Tj
0 g
()Tj
0.83 0.64 0.02 0 k
-35.4328 -1.2983 Td
(29)Tj
0 g
(].)Tj
1.7688 0 Td
(Their)Tj
2.4661 0 Td
(ATPase)Tj
3.3505 0 Td
(activity)Tj
3.1861 0 Td
(is)Tj
0.8674 0 Td
(stimulated)Tj
4.5128 0 Td
(in)Tj
1.0544 0 Td
(the)Tj
1.4967 0 Td
(presence)Tj
3.7871 0 Td
(of)Tj
1.0318 0 Td
(ParB)Tj
2.1997 0 Td
([)Tj
0.83 0.64 0.02 0 k
(30)Tj
0 g
()Tj
0.83 0.64 0.02 0 k
(32)Tj
0 g
(],)Tj
3.6169 0 Td
(which)Tj
2.6929 0 Td
(binds)Tj
2.4775 0 Td
(to)Tj
1.0432 0 Td
(the)Tj
ET
Q
q
1 j
1 J
0 w
576 737.1 m
36 737.1 l
36 737.6 l
576 737.6 l
f*
36 741.2598 169.285 23.6976 re
W* n
q
169.2283 0 0 23.6409 36 741.3165 cm
q
/I0 Do
Q
Q
Q
q
0 0 612 792 re
W* n
1 j
1 J
0 w
7.9999 0 0 7.9999 369.9779 745.7952 cm
BT
/F0 1 Tf
1 TL
-0.005 Tc
0 0 Td
(Regulatio)Tj
4.1386 0 Td
(n)Tj
0.7653 0 Td
(of)Tj
1.0418 0 Td
(Pom)Tj
2.2464 0 Td
(cluster)Tj
3.1182 0 Td
(dynamic)Tj
3.6567 0 Td
(s)Tj
0.7158 0 Td
(in)Tj
/F6 1 Tf
0.9779 0 Td
(Myxococcus)Tj
5.641 0 Td
(xanthus)Tj
ET
Q
q
1 j
1 J
0 w
36 48.0002 m
576 48.0002 l
576 47.5002 l
36 47.5002 l
f*
0.83 0.64 0.02 0 k
142.5827 34.9228 m
295.8236 34.9228 l
h
f*
0 g
7.9999 0 0 7.9999 36 36 cm
BT
/F0 1 Tf
1 TL
-0.005 Tc
0 0 Td
(PLOS)Tj
2.8559 0 Td
(Computationa)Tj
6.1229 0 Td
(l)Tj
0.4322 0 Td
(Biology)Tj
3.4371 0 Td
(|)Tj
0.83 0.64 0.02 0 k
0.4748 0 Td
(https:/)Tj
2.6788 0 Td
(/doi.org/10.13)Tj
6.0094 0 Td
(71/journal.p)Tj
5.1166 0 Td
(cbi.1006358)Tj
0 g
6.3497 0 Td
(August)Tj
3.2811 0 Td
(13,)Tj
1.5874 0 Td
(2018)Tj
26.7947 0 Td
(2)Tj
0.7654 0 Td
(/)Tj
0.496 0 Td
(28)Tj
/F11 1 Tf
-0.025 Tc
-66.402 84.0904 Td
(analysis,)Tj
3.4086 0 Td
(decision)Tj
3.2953 0 Td
(to)Tj
0.9497 0 Td
(publish,)Tj
3.1393 0 Td
(or)Tj
1.0064 0 Td
(prepara)Tj
2.8205 0 Td
(tion)Tj
1.6157 0 Td
(of)Tj
0.9496 0 Td
(the)Tj
-17.1851 -1.3748 Td
(manuscript.)Tj
/F10 1 Tf
0 -2.126 Td
(Competing)Tj
4.3795 0 Td
(interests)Tj
3.3307 0 Td
(:)Tj
/F11 1 Tf
0.4819 0 Td
(The)Tj
1.5875 0 Td
(authors)Tj
3.0401 0 Td
(have)Tj
1.963 0 Td
(declared)Tj
-14.7827 -1.3749 Td
(that)Tj
1.6228 0 Td
(no)Tj
1.1693 0 Td
(competing)Tj
4.1599 0 Td
(interests)Tj
ET
endstream
endobj
39 0 obj
<>stream
endstream
endobj
40 0 obj
<>stream
endstream
endobj
41 0 obj
<>stream
endstream
endobj
42 0 obj
<>stream
endstream
endobj
43 0 obj
<>stream
endstream
endobj
44 0 obj
<>stream
endstream
endobj
45 0 obj
<>stream
endstream
endobj
46 0 obj
<>stream
endstream
endobj
47 0 obj
<>stream
endstream
endobj
48 0 obj
<>stream
endstream
endobj
49 0 obj
<>stream
endstream
endobj
50 0 obj
<>stream
endstream
endobj
51 0 obj
<>stream
endstream
endobj
52 0 obj
<>stream
endstream
endobj
53 0 obj
<>stream
endstream
endobj
54 0 obj
<>stream
BT
10.3394 79.2147 Td
(exist.)Tj
ET
Q
endstream
endobj
55 0 obj
<>/XObject<>>>/CropBox[0 0 612 792]/MediaBox[0 0 612 792]/Parent 13 0 R/Annots 57 0 R/Contents 58 0 R/TrimBox[0 0 612 792]>>
endobj
57 0 obj
[59 0 R 60 0 R 61 0 R 62 0 R 63 0 R 64 0 R 65 0 R 66 0 R 67 0 R 68 0 R 69 0 R 70 0 R 71 0 R 72 0 R 73 0 R 74 0 R 75 0 R 76 0 R 77 0 R 78 0 R 79 0 R 80 0 R 81 0 R 82 0 R 83 0 R 84 0 R 85 0 R 86 0 R 87 0 R 88 0 R 89 0 R 90 0 R 91 0 R 92 0 R 93 0 R 94 0 R 95 0 R 96 0 R 97 0 R 98 0 R 99 0 R 100 0 R 101 0 R 102 0 R 103 0 R 104 0 R 105 0 R 106 0 R 107 0 R]
endobj
59 0 obj
<>/Border[0 0 0]/Dest(Rpcbi.1006358.ref003)>>
endobj
60 0 obj
<>/Border[0 0 0]/Dest(Rpcbi.1006358.ref033)>>
endobj
61 0 obj
<>/Border[0 0 0]/Dest(Rpcbi.1006358.ref034)>>
endobj
62 0 obj
<>/Border[0 0 0]/Dest(Rpcbi.1006358.ref035)>>
endobj
63 0 obj
<>/Border[0 0 0]/Dest(Rpcbi.1006358.ref026)>>
endobj
64 0 obj
<>/Border[0 0 0]/Dest(Rpcbi.1006358.ref036)>>
endobj
65 0 obj
<>/Border[0 0 0]/Dest(Rpcbi.1006358.ref037)>>
endobj
66 0 obj
<>/Border[0 0 0]/Dest(Rpcbi.1006358.ref024)>>
endobj
67 0 obj
<>/Border[0 0 0]/Dest(Rpcbi.1006358.ref025)>>
endobj
68 0 obj
<>/Border[0 0 0]/Dest(Rpcbi.1006358.ref038)>>
endobj
69 0 obj
<>/Border[0 0 0]/Dest(Rpcbi.1006358.ref039)>>
endobj
70 0 obj
<>/Border[0 0 0]/Dest(Rpcbi.1006358.ref024)>>
endobj
71 0 obj
<>/Border[0 0 0]/Dest(Rpcbi.1006358.ref026)>>
endobj
72 0 obj
<>/Border[0 0 0]/Dest(Rpcbi.1006358.ref036)>>
endobj
73 0 obj
<>/Border[0 0 0]/Dest(Rpcbi.1006358.ref037)>>
endobj
74 0 obj
<>/Border[0 0 0]/Dest(Rpcbi.1006358.ref024)>>
endobj
75 0 obj
<>/Border[0 0 0]/Dest(Rpcbi.1006358.ref030)>>
endobj
76 0 obj
<>/Border[0 0 0]/Dest(Rpcbi.1006358.ref033)>>
endobj
77 0 obj
<>/Border[0 0 0]/Dest(Rpcbi.1006358.ref040)>>
endobj
78 0 obj
<>/Border[0 0 0]/Dest(Rpcbi.1006358.ref043)>>
endobj
79 0 obj
<>/Border[0 0 0]/Dest(Rpcbi.1006358.ref039)>>
endobj
80 0 obj
<>/Border[0 0 0]/Dest(Rpcbi.1006358.ref044)>>
endobj
81 0 obj
<>/Border[0 0 0]/Dest(Rpcbi.1006358.ref045)>>
endobj
82 0 obj
<>/Border[0 0 0]/Dest(Rpcbi.1006358.ref032)>>
endobj
83 0 obj
<>/Border[0 0 0]/Dest(Rpcbi.1006358.ref045)>>
endobj
84 0 obj
<>/Border[0 0 0]/Dest(Rpcbi.1006358.ref049)>>
endobj
85 0 obj
<>/Border[0 0 0]/Dest(Rpcbi.1006358.ref039)>>
endobj
86 0 obj
<>/Border[0 0 0]/Dest(Rpcbi.1006358.ref050)>>
endobj
87 0 obj
<>/Border[0 0 0]/Dest(Rpcbi.1006358.ref039)>>
endobj
88 0 obj
<>/Border[0 0 0]/Dest(Rpcbi.1006358.ref051)>>
endobj
89 0 obj
<>/Border[0 0 0]/Dest(Rpcbi.1006358.ref036)>>
endobj
90 0 obj
<>/Border[0 0 0]/Dest(Rpcbi.1006358.ref036)>>
endobj
91 0 obj
<>/Border[0 0 0]/Dest(Rpcbi.1006358.ref052)>>
endobj
92 0 obj
<>/Border[0 0 0]/Dest(Rpcbi.1006358.ref055)>>
endobj
93 0 obj
<>/Border[0 0 0]/Dest(Rpcbi.1006358.ref005)>>
endobj
94 0 obj
<>/Border[0 0 0]/Dest(Rpcbi.1006358.s001)>>
endobj
95 0 obj
<>/Border[0 0 0]/Dest(Rpcbi.1006358.ref024)>>
endobj
96 0 obj
<>/Border[0 0 0]/Dest(Rpcbi.1006358.ref047)>>
endobj
97 0 obj
<>/Border[0 0 0]/Dest(Rpcbi.1006358.ref034)>>
endobj
98 0 obj
<>/Border[0 0 0]/Dest(Rpcbi.1006358.ref056)>>
endobj
99 0 obj
<>/Border[0 0 0]/Dest(Rpcbi.1006358.ref005)>>
endobj
100 0 obj
<>/Border[0 0 0]/Dest(Rpcbi.1006358.ref039)>>
endobj
101 0 obj
<>/Border[0 0 0]/Dest(Rpcbi.1006358.ref005)>>
endobj
102 0 obj
<>/Border[0 0 0]/Dest(Rpcbi.1006358.ref024)>>
endobj
103 0 obj
<>/Border[0 0 0]/Dest(Rpcbi.1006358.ref038)>>
endobj
104 0 obj
<>/Border[0 0 0]/Dest(Rpcbi.1006358.ref047)>>
endobj
105 0 obj
<>/Border[0 0 0]/Dest(Rpcbi.1006358.ref036)>>
endobj
106 0 obj
<>/Border[0 0 0]/Dest(Rpcbi.1006358.ref005)>>
endobj
107 0 obj
<>/Border[0 0 0]/A 108 0 R>>
endobj
108 0 obj
<>
endobj
58 0 obj
[109 0 R 110 0 R 111 0 R 112 0 R 113 0 R 114 0 R 115 0 R 116 0 R 117 0 R 118 0 R 119 0 R 120 0 R 121 0 R 122 0 R 123 0 R 124 0 R 125 0 R 126 0 R 127 0 R 128 0 R 129 0 R 130 0 R 131 0 R 132 0 R 133 0 R 134 0 R 135 0 R]
endobj
109 0 obj
<>stream
q
0.83 0.64 0.02 0 k
550.148 706.337 m
555.0236 706.337 l
h
f*
392.485 693.2976 m
402.1795 693.2976 l
h
f*
540.6803 680.315 m
550.3748 680.315 l
h
f*
554.9102 680.315 m
564.6047 680.315 l
h
f*
512.5039 654.3496 m
522.1984 654.3496 l
h
f*
526.7339 654.3496 m
536.4283 654.3496 l
h
f*
541.0205 654.3496 m
550.715 654.3496 l
h
f*
381.0331 641.3102 m
390.7276 641.3102 l
h
f*
395.263 641.3102 m
404.9575 641.3102 l
h
f*
409.4929 641.3102 m
419.1874 641.3102 l
h
f*
271.9559 628.3276 m
281.6504 628.3276 l
h
f*
203.4709 615.3449 m
213.1654 615.3449 l
h
f*
218.4378 615.3449 m
228.1323 615.3449 l
h
f*
232.6677 615.3449 m
242.3622 615.3449 l
h
f*
246.8976 615.3449 m
256.5921 615.3449 l
h
f*
417.3732 589.3228 m
426.8976 589.3228 l
h
f*
431.3764 589.3228 m
440.8441 589.3228 l
h
f*
445.3228 589.3228 m
454.8472 589.3228 l
h
f*
459.2693 589.3228 m
468.7937 589.3228 l
h
f*
473.9528 589.3228 m
483.4772 589.3228 l
h
f*
323.7165 576.3402 m
333.2409 576.3402 l
h
f*
337.663 576.3402 m
347.1874 576.3402 l
h
f*
351.6661 576.3402 m
361.1339 576.3402 l
h
f*
520.4976 563.3008 m
530.022 563.3008 l
h
f*
534.5008 563.3008 m
543.9685 563.3008 l
h
f*
549.1843 563.3008 m
558.652 563.3008 l
h
f*
431.7732 550.3181 m
441.2976 550.3181 l
h
f*
445.7764 550.3181 m
455.2441 550.3181 l
h
f*
432 537.3354 m
441.4677 537.3354 l
h
f*
445.9465 537.3354 m
455.4709 537.3354 l
h
f*
307.6157 498.3307 m
317.1402 498.3307 l
h
f*
284.2583 472.3087 m
293.7827 472.3087 l
h
f*
366.0094 459.326 m
375.5339 459.326 l
h
f*
380.6929 459.326 m
390.2173 459.326 l
h
f*
331.0866 433.3039 m
335.8488 433.3039 l
h
f*
280.4031 420.3213 m
310.0535 420.3213 l
h
f*
431.2063 394.2992 m
440.7307 394.2992 l
h
f*
445.2094 394.2992 m
454.7339 394.2992 l
h
f*
499.9181 381.3165 m
509.4425 381.3165 l
h
f*
513.8646 381.3165 m
523.389 381.3165 l
h
f*
243.326 355.3512 m
248.0882 355.3512 l
h
f*
535.2378 355.3512 m
544.7622 355.3512 l
h
f*
232.1008 329.3291 m
236.863 329.3291 l
h
f*
535.9181 316.3465 m
545.4425 316.3465 l
h
f*
549.8646 316.3465 m
559.389 316.3465 l
h
f*
200.0126 303.3071 m
209.537 303.3071 l
h
f*
548.9008 277.3417 m
558.4252 277.3417 l
h
f*
269.6882 251.3197 m
274.4504 251.3197 l
h
f*
0 g
1 j
1 J
0 w
10 0 0 10 200.0125 707.4141 cm
BT
/F8 1 Tf
1 TL
0.005 Tc
0 0 Td
[()4()16()]TJ
/F7 1 Tf
2.0295 0 Td
(sequence)Tj
3.9345 0 Td
(on)Tj
1.2926 0 Td
(the)Tj
1.4967 0 Td
(chromosome)Tj
5.5785 0 Td
(\(to)Tj
1.389 0 Td
(form)Tj
2.245 0 Td
(the)Tj
1.4967 0 Td
(partition)Tj
3.8097 0 Td
(complex\))Tj
4.0309 0 Td
(or)Tj
1.1168 0 Td
(on)Tj
1.2926 0 Td
(the)Tj
1.4967 0 Td
(plasmid)Tj
3.4582 0 Td
([)Tj
0.83 0.64 0.02 0 k
(3)Tj
0 g
(].)Tj
-34.6674 -1.3039 Td
(Besides)Tj
3.2258 0 Td
(plasmid)Tj
3.4525 0 Td
(and)Tj
1.7575 0 Td
(chromosome)Tj
5.5785 0 Td
(segregation)Tj
4.8869 0 Td
([)Tj
0.83 0.64 0.02 0 k
(33)Tj
0 g
(],)Tj
2.1203 0 Td
(ParAB)Tj
/F8 1 Tf
[()]TJ
/F7 1 Tf
3.3562 0 Td
(systems)Tj
3.3619 0 Td
(are)Tj
1.474 0 Td
(also)Tj
1.8028 0 Td
(important)Tj
4.3654 0 Td
(for)Tj
-35.3818 -1.2982 Td
(the)Tj
1.4966 0 Td
(positioning)Tj
4.8699 0 Td
(of)Tj
1.0318 0 Td
(cellular)Tj
3.2145 0 Td
(components)Tj
5.2611 0 Td
(\(e.g.)Tj
1.9445 0 Td
(chemotactic)Tj
5.1647 0 Td
(clusters)Tj
3.3052 0 Td
(or)Tj
1.1168 0 Td
(carboxysomes\))Tj
6.3099 0 Td
([)Tj
0.83 0.64 0.02 0 k
(34)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
1.7745 0 Td
(35)Tj
0 g
(].)Tj
-35.4895 -1.2983 Td
(Several)Tj
3.1124 0 Td
(different)Tj
3.736 0 Td
(cargo)Tj
2.4661 0 Td
(dynamics)Tj
4.1273 0 Td
(involving)Tj
4.0591 0 Td
(ParAB)Tj
/F8 1 Tf
[()]TJ
/F7 1 Tf
3.3562 0 Td
(systems)Tj
3.3619 0 Td
(have)Tj
2.0976 0 Td
(been)Tj
2.16 0 Td
(observed.)Tj
4.0989 0 Td
(For)Tj
1.6554 0 Td
(one)Tj
-34.2309 -1.2983 Td
(cargo)Tj
2.4661 0 Td
(these)Tj
2.296 0 Td
(localization)Tj
4.9209 0 Td
(patterns)Tj
3.5433 0 Td
(include,)Tj
3.4809 0 Td
(among)Tj
3.0388 0 Td
(others,)Tj
2.999 0 Td
(midcell)Tj
3.2371 0 Td
(localization)Tj
4.921 0 Td
([)Tj
0.83 0.64 0.02 0 k
(26)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
1.7688 0 Td
(36)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
1.4286 0 Td
(37)Tj
0 g
(],)Tj
-34.1005 -1.3039 Td
(oscillatory)Tj
4.4333 0 Td
(movement)Tj
4.5864 0 Td
(of)Tj
1.0318 0 Td
(ParA)Tj
2.3074 0 Td
(and)Tj
1.7575 0 Td
(its)Tj
1.1735 0 Td
(cargo)Tj
2.4662 0 Td
([)Tj
0.83 0.64 0.02 0 k
(24)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
1.7688 0 Td
(25)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
1.4229 0 Td
(38)Tj
0 g
(])Tj
1.5421 0 Td
(as)Tj
1.0318 0 Td
(well)Tj
1.8538 0 Td
(as)Tj
1.0375 0 Td
(movement)Tj
4.5864 0 Td
(from)Tj
2.2394 0 Td
(one)Tj
1.7234 0 Td
(cell)Tj
-34.9622 -1.2982 Td
(pole)Tj
1.9388 0 Td
(to)Tj
1.0318 0 Td
(the)Tj
1.4911 0 Td
(other)Tj
2.381 0 Td
([)Tj
0.83 0.64 0.02 0 k
(39)Tj
0 g
(].)Tj
2.1147 0 Td
(Multiple)Tj
3.702 0 Td
(cargoes)Tj
3.2598 0 Td
(are)Tj
1.4627 0 Td
(found)Tj
2.6589 0 Td
(to)Tj
1.0318 0 Td
(equidistantly)Tj
5.4878 0 Td
(position)Tj
3.5546 0 Td
(along)Tj
2.4605 0 Td
(the)Tj
1.4853 0 Td
(nucleoid)Tj
-34.0608 -1.2983 Td
([)Tj
0.83 0.64 0.02 0 k
(24)Tj
0 g
()Tj
0.83 0.64 0.02 0 k
(26)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
3.2654 0 Td
(36)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
1.423 0 Td
(37)Tj
0 g
(].)Tj
-0.004 Tc
-3.4922 -1.3039 Td
(To)Tj
1.3379 0 Td
(account)Tj
3.3846 0 Td
(for)Tj
1.3889 0 Td
(the)Tj
1.4684 0 Td
(dynamics)Tj
4.0535 0 Td
(observed)Tj
3.7984 0 Td
(in)Tj
1.0375 0 Td
(Par)Tj
1.5817 0 Td
(systems,)Tj
3.5262 0 Td
(various)Tj
3.1408 0 Td
(mechanisms)Tj
5.2044 0 Td
(have)Tj
2.0636 0 Td
(been)Tj
2.1203 0 Td
(pro-)Tj
-35.3024 -1.2983 Td
(posed.)Tj
2.7779 0 Td
(Some)Tj
2.4491 0 Td
(models)Tj
3.1068 0 Td
(rely)Tj
1.7121 0 Td
(on)Tj
1.2756 0 Td
(ParA)Tj
2.2677 0 Td
(filament)Tj
3.5489 0 Td
(formation)Tj
4.2576 0 Td
([)Tj
0.83 0.64 0.02 0 k
(24)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
1.7405 0 Td
(30)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
1.3946 0 Td
(33)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
1.3947 0 Td
(40)Tj
0 g
()Tj
0.83 0.64 0.02 0 k
(43)Tj
0 g
(],)Tj
3.2088 0 Td
(others)Tj
2.7042 0 Td
(challenge)Tj
3.9628 0 Td
(this)Tj
-35.8013 -1.2983 Td
(assumption)Tj
4.8585 0 Td
(in)Tj
/F8 1 Tf
1.0375 0 Td
[()12()]TJ
1.0148 0 Td
[()-13()15()3()]TJ
/F7 1 Tf
1.8198 0 Td
(systems)Tj
3.2995 0 Td
([)Tj
0.83 0.64 0.02 0 k
(39)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
1.7348 0 Td
(44)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
1.4003 0 Td
(45)Tj
0 g
(].)Tj
1.7348 0 Td
(A)Tj
0.9014 0 Td
(diffusion-ratchet)Tj
6.9335 0 Td
(mechanism)Tj
4.8416 0 Td
(for)Tj
1.3889 0 Td
(the)Tj
1.4684 0 Td
(movement)Tj
-32.4338 -1.3039 Td
(of)Tj
1.0147 0 Td
(ParB-coated)Tj
5.1251 0 Td
(beads)Tj
/F8 1 Tf
2.4774 0 Td
[()12()]TJ
1.0148 0 Td
[()-13()14()7()20()]TJ
/F7 1 Tf
2.0409 0 Td
(and)Tj
1.7348 0 Td
(DNA)Tj
2.3755 0 Td
(segregation)Tj
/F8 1 Tf
4.7848 0 Td
[()12()]TJ
1.0148 0 Td
[()-13()15()3()]TJ
/F7 1 Tf
1.8198 0 Td
(has)Tj
1.5421 0 Td
(been)Tj
2.1203 0 Td
(introduced)Tj
4.6431 0 Td
([)Tj
0.83 0.64 0.02 0 k
(32)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
1.7405 0 Td
(45)Tj
0 g
()Tj
0.83 0.64 0.02 0 k
(49)Tj
0 g
(].)Tj
-33.4486 -1.2982 Td
(Based)Tj
2.5454 0 Td
(on)Tj
1.2756 0 Td
(the)Tj
1.4684 0 Td
(observation)Tj
4.8982 0 Td
(that)Tj
1.7801 0 Td
(DNA)Tj
2.3755 0 Td
(has)Tj
1.542 0 Td
(elastic)Tj
2.6759 0 Td
(properties)Tj
4.2746 0 Td
([)Tj
0.83 0.64 0.02 0 k
(39)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
1.7405 0 Td
(50)Tj
0 g
(],)Tj
1.7348 0 Td
(a)Tj
0.6519 0 Td
(DNA-relay)Tj
4.6602 0 Td
(mechanism)Tj
-31.6231 -1.2983 Td
(for)Tj
1.3832 0 Td
(the)Tj
1.4741 0 Td
(movement)Tj
4.5127 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4683 0 Td
(partition)Tj
3.7304 0 Td
(complex)Tj
3.6226 0 Td
(was)Tj
1.7008 0 Td
(proposed)Tj
3.9515 0 Td
([)Tj
0.83 0.64 0.02 0 k
(39)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
1.7348 0 Td
(51)Tj
0 g
(].)Tj
1.7348 0 Td
(Here,)Tj
2.4321 0 Td
(the)Tj
1.4683 0 Td
(force)Tj
2.2337 0 Td
(exerted)Tj
3.1521 0 Td
(on)Tj
-35.6142 -1.3039 Td
(the)Tj
1.4683 0 Td
(cargo)Tj
2.4208 0 Td
(is)Tj
0.8503 0 Td
(attributed)Tj
4.1726 0 Td
(to)Tj
1.0262 0 Td
(the)Tj
1.4683 0 Td
(elastic)Tj
2.6702 0 Td
(properties)Tj
4.2803 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4683 0 Td
(chromosome.)Tj
5.7146 0 Td
(Ietswaart)Tj
3.8608 0 Td
(et)Tj
0.9468 0 Td
(al.)Tj
1.1225 0 Td
(observed)Tj
-32.4848 -1.2983 Td
(that)Tj
1.7744 0 Td
(if)Tj
0.7767 0 Td
(a)Tj
0.6576 0 Td
(plasmid)Tj
3.3903 0 Td
(is)Tj
0.8504 0 Td
(located)Tj
3.0784 0 Td
(off-center)Tj
4.1442 0 Td
(on)Tj
1.2756 0 Td
(the)Tj
1.4683 0 Td
(nucleoid,)Tj
3.9175 0 Td
(the)Tj
1.4683 0 Td
(ParA)Tj
2.2677 0 Td
(flux)Tj
1.7461 0 Td
(from)Tj
2.2054 0 Td
(the)Tj
1.4683 0 Td
(left)Tj
1.4797 0 Td
(and)Tj
1.7291 0 Td
(right)Tj
-33.698 -1.2982 Td
(sides)Tj
2.1599 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4684 0 Td
(plasmid)Tj
3.3959 0 Td
(differ)Tj
2.381 0 Td
([)Tj
0.83 0.64 0.02 0 k
(36)Tj
0 g
(].)Tj
2.0807 0 Td
(Based)Tj
2.5455 0 Td
(on)Tj
1.2755 0 Td
(this)Tj
1.6725 0 Td
(idea,)Tj
2.0976 0 Td
(they)Tj
1.9219 0 Td
(proposed)Tj
3.9571 0 Td
(a)Tj
0.652 0 Td
(model)Tj
2.7439 0 Td
(that)Tj
1.7801 0 Td
(produces)Tj
3.8778 0 Td
(equal)Tj
-35.0246 -1.2983 Td
(plasmid)Tj
3.3902 0 Td
(spacing)Tj
3.2371 0 Td
(over)Tj
1.9786 0 Td
(the)Tj
1.4683 0 Td
(nucleoid)Tj
3.6907 0 Td
(as)Tj
1.0148 0 Td
(long)Tj
1.9899 0 Td
(as)Tj
1.0148 0 Td
(the)Tj
1.4683 0 Td
(plasmid)Tj
3.3903 0 Td
(moves)Tj
2.7892 0 Td
(in)Tj
1.0318 0 Td
(the)Tj
1.474 0 Td
(direction)Tj
3.8495 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.474 0 Td
(higher)Tj
-34.2763 -1.3039 Td
(ParA)Tj
2.2677 0 Td
(concentration)Tj
5.8166 0 Td
([)Tj
0.83 0.64 0.02 0 k
(36)Tj
0 g
(].)Tj
2.0806 0 Td
(Additionally,)Tj
5.4538 0 Td
(models)Tj
3.1011 0 Td
(based)Tj
2.4775 0 Td
(on)Tj
1.2756 0 Td
(reaction-diffusion)Tj
7.421 0 Td
(equations)Tj
4.0989 0 Td
(for)Tj
1.3833 0 Td
(Par)Tj
-35.3761 -1.2983 Td
(protein)Tj
3.1521 0 Td
(dynamics,)Tj
4.2802 0 Td
(have)Tj
2.0637 0 Td
(been)Tj
2.1203 0 Td
(introduced)Tj
4.6431 0 Td
([)Tj
0.83 0.64 0.02 0 k
(52)Tj
0 g
()Tj
0.83 0.64 0.02 0 k
(55)Tj
0 g
(].)Tj
-15.0632 -1.2983 Td
(In)Tj
1.1055 0 Td
(order)Tj
2.4151 0 Td
(to)Tj
1.0148 0 Td
(account)Tj
3.3788 0 Td
(for)Tj
1.3777 0 Td
(the)Tj
1.4626 0 Td
(experimental)Tj
5.4539 0 Td
(observations)Tj
5.2497 0 Td
(in)Tj
/F8 1 Tf
1.0318 0 Td
[()]TJ
1.3096 0 Td
[()-4()16()22()10()18()-4( )]TJ
/F7 1 Tf
3.3562 0 Td
(cells,)Tj
2.1373 0 Td
(we)Tj
1.3209 0 Td
(have)Tj
2.0523 0 Td
(proposed)Tj
-33.8624 -1.3039 Td
(a)Tj
0.6519 0 Td
(model)Tj
2.7439 0 Td
(for)Tj
1.389 0 Td
(midcell)Tj
3.1748 0 Td
(localization)Tj
4.8075 0 Td
([)Tj
0.83 0.64 0.02 0 k
(5)Tj
0 g
(])Tj
1.3776 0 Td
(that)Tj
1.7802 0 Td
(is)Tj
0.8447 0 Td
(inspired)Tj
3.5036 0 Td
(by,)Tj
1.406 0 Td
(but)Tj
1.5534 0 Td
(also)Tj
1.7688 0 Td
(differs)Tj
2.7496 0 Td
(from)Tj
2.2053 0 Td
(previous)Tj
3.6453 0 Td
(models)Tj
-33.6016 -1.2982 Td
(for)Tj
1.3832 0 Td
(Par)Tj
1.5874 0 Td
(systems)Tj
3.2995 0 Td
(\(see)Tj
0.83 0.64 0.02 0 k
1.7689 0 Td
(S1)Tj
1.1678 0 Td
(Text)Tj
0 g
(\).)Tj
2.5852 0 Td
(The)Tj
1.7801 0 Td
(key)Tj
1.5988 0 Td
(experimental)Tj
5.4538 0 Td
(observations)Tj
5.2611 0 Td
(for)Tj
1.3889 0 Td
(the)Tj
1.4684 0 Td
(Pom)Tj
2.1033 0 Td
(system)Tj
2.9423 0 Td
(are:)Tj
1.6724 0 Td
(First,)Tj
-35.4611 -1.2983 Td
(PomZ)Tj
2.7042 0 Td
(accumulates)Tj
5.142 0 Td
(at)Tj
0.9524 0 Td
(the)Tj
1.4684 0 Td
(cluster)Tj
2.8686 0 Td
(consisting)Tj
4.269 0 Td
(of)Tj
1.0148 0 Td
(PomX)Tj
2.7609 0 Td
(and)Tj
1.7291 0 Td
(PomY)Tj
2.7383 0 Td
(proteins,)Tj
3.736 0 Td
(which)Tj
2.6532 0 Td
(is)Tj
0.8447 0 Td
(in)Tj
1.0375 0 Td
(contrast)Tj
-33.9191 -1.3039 Td
(to)Tj
1.0261 0 Td
(a)Tj
0.6519 0 Td
(low)Tj
1.6555 0 Td
(ParA)Tj
2.2677 0 Td
(density)Tj
3.1011 0 Td
(at)Tj
0.9524 0 Td
(plasmids)Tj
3.7587 0 Td
(/)Tj
0.5443 0 Td
(the)Tj
1.474 0 Td
(partition)Tj
3.7247 0 Td
(complex)Tj
3.6226 0 Td
([)Tj
0.83 0.64 0.02 0 k
(24)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
1.7405 0 Td
(47)Tj
0 g
(].)Tj
1.7348 0 Td
(Conversely,)Tj
4.8982 0 Td
(there)Tj
2.2677 0 Td
(are)Tj
1.4457 0 Td
(also)Tj
-34.8659 -1.2983 Td
(positioning)Tj
4.7735 0 Td
(systems)Tj
3.2995 0 Td
(that)Tj
1.7744 0 Td
(show)Tj
2.3018 0 Td
(an)Tj
1.2018 0 Td
(accumulation)Tj
5.6806 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4684 0 Td
(ATPase)Tj
3.2938 0 Td
(at)Tj
0.9524 0 Td
(the)Tj
1.4684 0 Td
(cargo)Tj
2.4208 0 Td
([)Tj
0.83 0.64 0.02 0 k
(34)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
1.7347 0 Td
(56)Tj
0 g
(],)Tj
1.7405 0 Td
(which)Tj
-33.1254 -1.2983 Td
(resembles)Tj
4.1555 0 Td
(the)Tj
1.4684 0 Td
(observations)Tj
5.261 0 Td
(for)Tj
1.389 0 Td
(the)Tj
1.4683 0 Td
(Pom)Tj
2.1033 0 Td
(system.)Tj
3.1635 0 Td
(Second,)Tj
3.3505 0 Td
(the)Tj
1.474 0 Td
(cluster)Tj
2.8686 0 Td
(is)Tj
0.8504 0 Td
(relatively)Tj
3.8381 0 Td
(large)Tj
2.16 0 Td
(\(0.7)Tj
/F14 1 Tf
1.7348 0 Td
[()]TJ
/F7 1 Tf
(m)Tj
-35.2854 -1.2982 Td
(in)Tj
1.0318 0 Td
(length,)Tj
2.9593 0 Td
([)Tj
0.83 0.64 0.02 0 k
(5)Tj
0 g
(]\))Tj
1.7121 0 Td
(compared)Tj
4.2463 0 Td
(to)Tj
1.0261 0 Td
(plasmids)Tj
3.7531 0 Td
(/)Tj
0.5499 0 Td
(partition)Tj
3.7304 0 Td
(complexes)Tj
4.405 0 Td
(\(about)Tj
2.8346 0 Td
(0.1)Tj
/F14 1 Tf
1.3946 0 Td
[()]TJ
/F7 1 Tf
(m)Tj
1.5477 0 Td
(in)Tj
1.0375 0 Td
(length,)Tj
2.9537 0 Td
([)Tj
0.83 0.64 0.02 0 k
(39)Tj
0 g
(]\).)Tj
-33.1821 -1.3039 Td
(Third,)Tj
2.7495 0 Td
(the)Tj
1.4684 0 Td
(PomZ)Tj
2.7099 0 Td
(proteins)Tj
3.5092 0 Td
(diffuse)Tj
2.9027 0 Td
(quickly)Tj
3.1464 0 Td
(on)Tj
1.2756 0 Td
(the)Tj
1.4684 0 Td
(nucleoid)Tj
3.6907 0 Td
(compared)Tj
4.2462 0 Td
(to)Tj
1.0262 0 Td
(a)Tj
0.6519 0 Td
(slowly)Tj
2.7156 0 Td
(moving)Tj
3.2825 0 Td
(Pom)Tj
-34.8432 -1.2983 Td
(cluster)Tj
2.8686 0 Td
([)Tj
0.83 0.64 0.02 0 k
(5)Tj
0 g
(].)Tj
1.6044 0 Td
(Finally,)Tj
3.1691 0 Td
(fluorescence)Tj
5.1874 0 Td
(micrographs)Tj
5.2837 0 Td
(of)Tj
/F8 1 Tf
1.0148 0 Td
[()]TJ
1.3153 0 Td
[()-4()16()22()10()18()-4( )]TJ
/F7 1 Tf
3.3619 0 Td
(cells)Tj
1.9218 0 Td
(do)Tj
1.2529 0 Td
(not)Tj
1.5761 0 Td
(show)Tj
2.3017 0 Td
(a)Tj
0.652 0 Td
(clear)Tj
2.1203 0 Td
(depletion)Tj
-33.63 -1.2983 Td
(zone)Tj
2.1089 0 Td
(in)Tj
1.0375 0 Td
(PomZ)Tj
2.7042 0 Td
(in)Tj
1.0375 0 Td
(the)Tj
1.4683 0 Td
(wake)Tj
2.2621 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4683 0 Td
(cluster,)Tj
3.0954 0 Td
(in)Tj
1.0375 0 Td
(contrast)Tj
3.4582 0 Td
(to)Tj
1.0262 0 Td
(observations)Tj
5.261 0 Td
(for)Tj
1.389 0 Td
(Par)Tj
1.5817 0 Td
(systems)Tj
3.2995 0 Td
([)Tj
0.83 0.64 0.02 0 k
(24)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
1.7348 0 Td
(38)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
-34.9849 -1.3039 Td
(47)Tj
0 g
(].)Tj
1.7347 0 Td
(The)Tj
1.7859 0 Td
(latter)Tj
2.2903 0 Td
(observation)Tj
4.8983 0 Td
(can)Tj
1.6271 0 Td
(be)Tj
1.1508 0 Td
(explained)Tj
4.0705 0 Td
(by)Tj
1.1849 0 Td
(the)Tj
1.4683 0 Td
(fast)Tj
1.5988 0 Td
(PomZ)Tj
2.7099 0 Td
(dynamics)Tj
4.0535 0 Td
(on)Tj
1.2756 0 Td
(the)Tj
1.4683 0 Td
(nucleoid.)Tj
3.9175 0 Td
(Our)Tj
-35.2344 -1.2982 Td
(model)Tj
2.7439 0 Td
(suggests)Tj
3.4809 0 Td
(a)Tj
0.652 0 Td
(positioning)Tj
4.7791 0 Td
(mechanism)Tj
4.8416 0 Td
(that)Tj
1.7801 0 Td
(relies)Tj
2.3131 0 Td
(on)Tj
1.2756 0 Td
(the)Tj
1.4683 0 Td
(biasing)Tj
3.0671 0 Td
(of)Tj
1.0148 0 Td
(fluxes)Tj
2.5341 0 Td
(of)Tj
1.0148 0 Td
(PomZ)Tj
2.7043 0 Td
(dimers)Tj
-33.6697 -1.2983 Td
(on)Tj
1.2755 0 Td
(the)Tj
1.4684 0 Td
(nucleoid,)Tj
3.9174 0 Td
(similar)Tj
2.9877 0 Td
(to)Tj
1.0205 0 Td
(the)Tj
1.474 0 Td
(equipositioning)Tj
6.497 0 Td
(mechanism)Tj
4.8472 0 Td
(proposed)Tj
3.9514 0 Td
(by)Tj
1.1793 0 Td
(Ietswaart)Tj
3.8664 0 Td
(et)Tj
0.9411 0 Td
(al.)Tj
1.1225 0 Td
([)Tj
0.83 0.64 0.02 0 k
(36)Tj
0 g
(].)Tj
-34.5484 -1.3039 Td
(With)Tj
2.279 0 Td
(this)Tj
1.6724 0 Td
(model)Tj
2.7439 0 Td
(we)Tj
1.3266 0 Td
(were)Tj
2.126 0 Td
(able)Tj
1.8312 0 Td
(to)Tj
1.0205 0 Td
(reproduce)Tj
4.3143 0 Td
(midnucleoid)Tj
5.3064 0 Td
(localization)Tj
4.8132 0 Td
(with)Tj
1.9956 0 Td
(physiologically)Tj
6.1454 0 Td
(rele-)Tj
-35.5745 -1.2983 Td
(vant)Tj
1.9558 0 Td
(parameters)Tj
4.6715 0 Td
([)Tj
0.83 0.64 0.02 0 k
(5)Tj
0 g
(],)Tj
1.6044 0 Td
(but)Tj
1.5534 0 Td
(it)Tj
0.7823 0 Td
(remained)Tj
4.0366 0 Td
(unclear)Tj
3.1917 0 Td
(how)Tj
1.9389 0 Td
(the)Tj
1.474 0 Td
(movement)Tj
4.5128 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4683 0 Td
(cluster)Tj
2.8743 0 Td
(changes)Tj
3.4016 0 Td
(when)Tj
-34.4804 -1.2983 Td
(the)Tj
1.4683 0 Td
(rates)Tj
2.109 0 Td
(of)Tj
1.0147 0 Td
(the)Tj
1.4684 0 Td
(key)Tj
1.593 0 Td
(biological)Tj
4.0932 0 Td
(processes)Tj
3.9685 0 Td
(involved)Tj
3.651 0 Td
(are)Tj
1.4457 0 Td
(varied.)Tj
-19.6156 -1.3039 Td
(Here,)Tj
2.4321 0 Td
(we)Tj
1.3266 0 Td
(investigate)Tj
4.4617 0 Td
(the)Tj
1.474 0 Td
(robustness)Tj
4.4844 0 Td
(of)Tj
1.0148 0 Td
(Pom)Tj
2.1033 0 Td
(cluster)Tj
2.8743 0 Td
(dynamics)Tj
4.0535 0 Td
(in)Tj
1.0375 0 Td
(our)Tj
1.627 0 Td
(model)Tj
2.744 0 Td
(with)Tj
1.9955 0 Td
(respect)Tj
3.0388 0 Td
(to)Tj
-35.8637 -1.2982 Td
(different)Tj
3.6566 0 Td
(parameters,)Tj
4.8983 0 Td
(so)Tj
1.0885 0 Td
(that)Tj
1.7744 0 Td
(our)Tj
1.6271 0 Td
(model)Tj
2.7439 0 Td
(can)Tj
1.6271 0 Td
(be)Tj
1.1509 0 Td
(tested)Tj
2.5511 0 Td
(by)Tj
1.1849 0 Td
(experimentally)Tj
6.1568 0 Td
(examining)Tj
4.4617 0 Td
(this)Tj
1.6724 0 Td
(robust-)Tj
-34.5937 -1.2983 Td
(ness.)Tj
2.1373 0 Td
(Interestingly,)Tj
5.4935 0 Td
(we)Tj
1.3266 0 Td
(observe)Tj
3.2655 0 Td
(that)Tj
1.7801 0 Td
(there)Tj
2.2677 0 Td
(exists)Tj
2.3924 0 Td
(an)Tj
1.2019 0 Td
(intermediate)Tj
5.3235 0 Td
(ATP)Tj
2.0749 0 Td
(hydrolysis)Tj
4.2973 0 Td
(rate)Tj
1.7461 0 Td
(that)Tj
1.7802 0 Td
(mini-)Tj
-35.087 -1.2983 Td
(mizes)Tj
2.5058 0 Td
(the)Tj
1.4683 0 Td
(time)Tj
2.0296 0 Td
(the)Tj
1.4683 0 Td
(clusters)Tj
3.2315 0 Td
(need)Tj
2.143 0 Td
(to)Tj
1.0261 0 Td
(reach)Tj
2.3981 0 Td
(midnucleoid.)Tj
5.5332 0 Td
(Furthermore,)Tj
5.6126 0 Td
(we)Tj
1.3266 0 Td
(find)Tj
1.8538 0 Td
(that)Tj
1.7802 0 Td
(fast)Tj
1.5987 0 Td
(diffusion)Tj
-33.9758 -1.3039 Td
(of)Tj
1.0147 0 Td
(PomZ)Tj
2.7043 0 Td
(dimers)Tj
2.9933 0 Td
(on)Tj
1.2756 0 Td
(the)Tj
1.4684 0 Td
(cluster)Tj
2.8686 0 Td
(accelerates)Tj
4.4844 0 Td
(the)Tj
1.4683 0 Td
(movement)Tj
4.5184 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4684 0 Td
(cluster)Tj
2.8686 0 Td
(towards)Tj
3.4072 0 Td
(midnucleoid.)Tj
-31.555 -1.2983 Td
(To)Tj
1.3379 0 Td
(gain)Tj
1.9332 0 Td
(a)Tj
0.652 0 Td
(better)Tj
2.5455 0 Td
(understanding)Tj
6.0661 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.474 0 Td
(cluster)Tj
2.8686 0 Td
(dynamics)Tj
4.0592 0 Td
(observed)Tj
3.7927 0 Td
(in)Tj
1.0375 0 Td
(the)Tj
/F8 1 Tf
1.4684 0 Td
[()12()]TJ
1.0147 0 Td
[( )10()4()12()4()7()]TJ
/F7 1 Tf
2.1544 0 Td
(parameter)Tj
-31.419 -1.2982 Td
(sweeps,)Tj
3.2144 0 Td
(we)Tj
1.3266 0 Td
(investigate)Tj
4.4617 0 Td
(how)Tj
1.9389 0 Td
(PomZ)Tj
2.7042 0 Td
(dimers)Tj
2.9934 0 Td
(generate)Tj
3.6057 0 Td
(a)Tj
0.6576 0 Td
(net)Tj
1.491 0 Td
(force)Tj
2.228 0 Td
(on)Tj
1.2756 0 Td
(the)Tj
1.474 0 Td
(cluster)Tj
2.8687 0 Td
(in)Tj
1.0374 0 Td
(our)Tj
1.6271 0 Td
(model.)Tj
2.965 0 Td
(For)Tj
-35.8693 -1.3039 Td
(the)Tj
1.4683 0 Td
(case)Tj
1.8595 0 Td
(where)Tj
2.6532 0 Td
(the)Tj
1.4684 0 Td
(PomZ)Tj
2.7042 0 Td
(gradient)Tj
3.5603 0 Td
(builds)Tj
2.6532 0 Td
(up)Tj
1.2642 0 Td
(faster)Tj
2.3981 0 Td
(than)Tj
2.0296 0 Td
(the)Tj
1.4684 0 Td
(velocity)Tj
3.2938 0 Td
(of)Tj
1.0148 0 Td
(cluster)Tj
2.8743 0 Td
(movement,)Tj
4.7395 0 Td
(we)Tj
-35.4498 -1.2983 Td
(derive)Tj
2.6872 0 Td
(a)Tj
0.6519 0 Td
(semi-analytical)Tj
6.2306 0 Td
(approximation)Tj
6.1738 0 Td
(for)Tj
1.3833 0 Td
(the)Tj
1.474 0 Td
(average)Tj
3.2258 0 Td
(cluster)Tj
2.8686 0 Td
(trajectory,)Tj
4.286 0 Td
(which)Tj
2.6475 0 Td
(dissects)Tj
3.2428 0 Td
(the)Tj
-34.8715 -1.2983 Td
(generation)Tj
4.507 0 Td
(of)Tj
1.0148 0 Td
(a)Tj
0.652 0 Td
(net)Tj
1.491 0 Td
(force)Tj
2.2337 0 Td
(into)Tj
1.8425 0 Td
(two)Tj
1.7064 0 Td
(parts:)Tj
2.4265 0 Td
(the)Tj
1.474 0 Td
(difference)Tj
4.2009 0 Td
(between)Tj
3.5319 0 Td
(the)Tj
1.4684 0 Td
(diffusive)Tj
3.6226 0 Td
(PomZ)Tj
2.7099 0 Td
(fluxes)Tj
-32.8816 -1.3039 Td
(into)Tj
1.8425 0 Td
(the)Tj
1.4683 0 Td
(cluster)Tj
2.8686 0 Td
(from)Tj
2.2054 0 Td
(either)Tj
2.5341 0 Td
(side,)Tj
2.024 0 Td
(and)Tj
1.7291 0 Td
(the)Tj
1.4683 0 Td
(force)Tj
2.2337 0 Td
(exerted)Tj
3.1578 0 Td
(by)Tj
1.1792 0 Td
(a)Tj
0.652 0 Td
(single)Tj
2.5341 0 Td
(PomZ)Tj
2.7042 0 Td
(dimer)Tj
2.6306 0 Td
(during)Tj
2.9253 0 Td
(its)Tj
-34.1572 -1.2982 Td
(interaction)Tj
4.6034 0 Td
(with)Tj
2.0012 0 Td
(the)Tj
1.4684 0 Td
(cluster.)Tj
3.0954 0 Td
(This)Tj
1.9899 0 Td
(net)Tj
1.491 0 Td
(force)Tj
2.2337 0 Td
(can)Tj
1.6214 0 Td
(account)Tj
3.3845 0 Td
(for)Tj
1.389 0 Td
(the)Tj
1.4684 0 Td
(movement)Tj
4.5127 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4683 0 Td
(cluster)Tj
2.8743 0 Td
(to)Tj
ET
Q
q
1 j
1 J
0 w
576 737.1 m
36 737.1 l
36 737.6 l
576 737.6 l
f*
36 741.2598 169.285 23.6976 re
W* n
q
169.2283 0 0 23.6409 36 741.3165 cm
q
/I0 Do
Q
Q
Q
q
0 0 612 792 re
W* n
1 j
1 J
0 w
7.9999 0 0 7.9999 369.9779 745.7952 cm
BT
/F0 1 Tf
1 TL
-0.005 Tc
0 0 Td
(Regulatio)Tj
4.1386 0 Td
(n)Tj
0.7653 0 Td
(of)Tj
1.0418 0 Td
(Pom)Tj
2.2464 0 Td
(cluster)Tj
3.1182 0 Td
(dynamic)Tj
3.6567 0 Td
(s)Tj
0.7158 0 Td
(in)Tj
/F6 1 Tf
0.9779 0 Td
(Myxococcus)Tj
5.641 0 Td
(xanthus)Tj
ET
Q
q
1 j
1 J
0 w
36 48.0002 m
576 48.0002 l
576 47.5002 l
36 47.5002 l
f*
0.83 0.64 0.02 0 k
142.5827 34.9228 m
295.8236 34.9228 l
h
f*
0 g
7.9999 0 0 7.9999 36 36 cm
BT
/F0 1 Tf
1 TL
-0.005 Tc
0 0 Td
(PLOS)Tj
2.8559 0 Td
(Computationa)Tj
6.1229 0 Td
(l)Tj
0.4322 0 Td
(Biology)Tj
3.4371 0 Td
(|)Tj
0.83 0.64 0.02 0 k
0.4748 0 Td
(https:/)Tj
2.6788 0 Td
(/doi.org/10.13)Tj
6.0094 0 Td
(71/journal.p)Tj
5.1166 0 Td
(cbi.1006358)Tj
0 g
6.3497 0 Td
(August)Tj
3.2811 0 Td
(13,)Tj
1.5874 0 Td
(2018)Tj
26.7947 0 Td
(3)Tj
0.7654 0 Td
(/)Tj
ET
endstream
endobj
110 0 obj
<>stream
endstream
endobj
111 0 obj
<>stream
endstream
endobj
112 0 obj
<>stream
endstream
endobj
113 0 obj
<>stream
endstream
endobj
114 0 obj
<>stream
endstream
endobj
115 0 obj
<>stream
endstream
endobj
116 0 obj
<>stream
endstream
endobj
117 0 obj
<>stream
endstream
endobj
118 0 obj
<>stream
endstream
endobj
119 0 obj
<>stream
endstream
endobj
120 0 obj
<>stream
endstream
endobj
121 0 obj
<>stream
endstream
endobj
122 0 obj
<>stream
endstream
endobj
123 0 obj
<>stream
endstream
endobj
124 0 obj
<>stream
endstream
endobj
125 0 obj
<>stream
endstream
endobj
126 0 obj
<>stream
endstream
endobj
127 0 obj
<>stream
endstream
endobj
128 0 obj
<>stream
endstream
endobj
129 0 obj
<>stream
endstream
endobj
130 0 obj
<>stream
endstream
endobj
131 0 obj
<>stream
endstream
endobj
132 0 obj
<>stream
endstream
endobj
133 0 obj
<>stream
endstream
endobj
134 0 obj
<>stream
endstream
endobj
135 0 obj
<>stream
BT
66.402 0 Td
(28)Tj
ET
Q
endstream
endobj
136 0 obj
<>/XObject<>>>/CropBox[0 0 612 792]/MediaBox[0 0 612 792]/Parent 13 0 R/Annots 139 0 R/Contents 140 0 R/TrimBox[0 0 612 792]>>
endobj
138 0 obj
<>stream
JFIF C
$, !$4.763.22:ASF:=N>22HbINVX]^]8EfmeZlS[]Y C**Y;2;YYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYY "
} !1AQa"q2#BR$3br
%&'()*456789:CDEFGHIJSTUVWXYZcdefghijstuvwxyz
w !1AQaq"2B #3Rbr
$4%&'()*56789:CDEFGHIJSTUVWXYZcdefghijstuvwxyz ? (
(
(
(
(
(
(
(
(
(
(
(
(
(
(
(
(
(
(
(
(
(
(
(
(
(
(
(
(
(
(
(
(
(
(
(
(
(
(
(
(
(
(
(
(
(
(
(
(
(
(
(
(
(+DӥK
t>PkEyǁcj:ٱgY|W9 u s]ڬeM*ƀ:J+ŗ~%x!x~ @Ex5_A6:v^*ZF-.99=ʊ+ZΕớ)s@T62
n^*;+q?M {EAz<
?@ o8ǝ C@ Z (bҺ2# OxX