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Kruger, Stephan F.; Cadilha, Bruno L.; Bergwelt‐Baildon, Michael von; Endres, Stefan und Kobold, Sebastian (2020): Challenges in Clinical Trial Design for T Cell‐Based Cancer Immunotherapy. In: Clinical Pharmacology & Therapeutics, Bd. 107, Nr. 1: S. 47-49 [PDF, 236kB]

Abstract

Chimeric antigen receptor T cells can induce impressive response rates in patients with refractory B cell malignancies. Adoptive transfer of tumor infiltrating lymphocytes or T cell receptor‐engineered T cells are other promising treatment modalities currently in clinical development. Requirements for clinical trial design for T cell‐based cancer immunotherapy significantly differ from established criteria for small‐molecule or antibody‐based anticancer drugs. Here, we highlight important differences regarding preclinical development, trial design, and reporting of clinical trials.

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