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Kellerer, Albrecht M.; Brenot, J. (1974): On the statistical evaluation of dose-response functions. In: Radiation and environmental biophysics, Vol. 11, No. 1: pp. 1-13




The linear-quadratic dependence of effect on the dose of ionizing radiation and its biophysical implications are considered. The estimation of the parameters of the response function and the derivation of the joint confidence region of the estimates are described. The method is applied to the induction of pink mutations inTradescantia which follows the linear-quadratic model. The statistical procedure is also suitable for other response functions.