?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=Simultaneous+Inference+in+General+Parametric+Models&rft.creator=Hothorn%2C+Torsten&rft.creator=Bretz%2C+Frank&rft.creator=Westfall%2C+Peter&rft.subject=Technische+Reports&rft.description=Simultaneous+inference+is+a+common+problem+in+many+areas+of+application.+If+multiple+null+hypotheses+are+tested+simultaneously%2C+the+probability+of+rejecting+erroneously+at+least+one+of+them+increases+beyond+the+pre-specified+significance+level.+Simultaneous+inference+procedures+have+to+be+used+which+adjust+for+multiplicity+and+thus+control+the+overall+type+I+error+rate.+In+this+paper+we+describe+simultaneous+inference+procedures+in+general+parametric+models%2C+where+the+experimental+questions+are+specified+through+a+linear+combination+of+elemental+model+parameters.+The+framework+described+here+is+quite+general+and+extends+the+canonical+theory+of+multiple+comparison+procedures+in+ANOVA+models+to+linear+regression+problems%2C+generalized+linear+models%2C+linear+mixed+effects+models%2C+the+Cox+model%2C+robust+linear+models%2C+etc.+Several+examples+using+a+variety+of+different+statistical+models+illustrate+the+breadth+of+the+results.+For+the+analyses+we+use+the+R+add-on+package+multcomp%2C+which+provides+a+convenient+interface+to+the+general+approach+adopted+here.&rft.date=2008-01-01&rft.language=eng&rft.type=doc-type%3AworkingPaper&rft.type=Paper&rft.type=NonPeerReviewed&rft.identifier=https%3A%2F%2Fepub.ub.uni-muenchen.de%2F2120%2F1%2Ftr019.pdf&rft.format=application%2Fpdf&rft.identifier=http%3A%2F%2Fnbn-resolving.de%2Furn%3Anbn%3Ade%3Abvb%3A19-epub-2120-8&rft.identifier=https%3A%2F%2Fepub.ub.uni-muenchen.de%2F2120%2F&rft.identifier=urn%3Anbn%3Ade%3Abvb%3A19-epub-2120-8&rft.identifier=+++Hothorn%2C+Torsten%3B+Bretz%2C+Frank+und+Westfall%2C+Peter+++(2008)%3A+++++Simultaneous+Inference+in+General+Parametric+Models.+++++++++++++++Department+of+Statistics%3A+Technical+Reports%2C+Nr.+19++++++++++%5BPDF%2C+416kB%5D++++++