Primary structure and functional expression of a cyclic nucleotidegated channel from rabbit aorta

Biel, Martin and Altenhofen, Wolfram and Hullin, Roger and Ludwig, Jost and Freichel, Marc and Flockerzi, Veit and Dascal, Nathan and Kaupp, U. Benjamin and Hofmann, Franz (1993): Primary structure and functional expression of a cyclic nucleotidegated channel from rabbit aorta. In: FEBS Letters, Vol. 329, No. 1 - 2: pp. 134-138

Abstract

Sequences specific for cyclic nucleotide-gated channels (CNG channels) have been amplified by PCR from cDNA of heart, aorta, sinoatrial node, cerebellum, C-cells and kidney. The complete amino acid sequence of a CNG channel from rabbit aorta has been deduced by cloning and sequence analysis of the cDNA. Synthetic RNA derived from this cDNA induces the formation of a functional CNG channel in Xenopus oocytes.

• Item Type: Article
• Keywords: Cyclic nucleotidegated channel; Aorta; Primary structure; Expression
• Collections: Chemistry and Pharmacy
• Subjects: 500 Science > 540 Chemistry