Logo
DeutschClear Cookie - decide language by browser settings
Gerbes, Alexander L. and Jüngst, Dieter and Paumgartner, Gustav and Sauerbruch, Tilman and Remien, Jörg (1986): Evidence for down-regulation of beta-2-adreno-ceptors in cirrhotic patients with severe ascites. In: The Lancet, Vol. 330: pp. 1409-1411
[img]
Preview

PDF

291kB

Abstract

The density and affinity of beta-2-adrenoceptors on mononuclear cells from peripheral blood were studied in fifteen patients with cirrhosis of different severity and in thirteen controls. There was no significant difference between cirrhotic patients and controls in density or affinity of beta-2 binding sites. Within the cirrhotic group, however, the number of binding sites per cell was significantly lower in patients with severe ascites than in patients with mild to moderate or no ascites. This down-regulation of beta-adrenoceptors could influence the haemodynamic response to beta-blockers.