Protein folding in mitochondria requires complex formation with hsp60 and ATP hydrolysis

Ostermann, Joachim and Horwich, Arthur and Neupert, Walter and Hartl, Franz-Ulrich (1989): Protein folding in mitochondria requires complex formation with hsp60 and ATP hydrolysis. In: Nature, Vol. 341: pp. 125-130

Abstract

Mitochondrial heat-shock protein hsp60 functions in the folding of proteins imported into mitochondria. Folding occurs at the surface of hsp60 in an ATP-mediated reaction, followed by release of the bound polypeptides. We propose that hsp60 catalyses protein folding.

• Item Type: Article
• Collections: Medicine
• Subjects: 600 Technology > 610 Medicine and health