Ultrafine particles, blood pressure and adult hypertension: a population-based survey in Northeast China

Lin, Li-Zi; Gao, Meng; Xiao, Xiang; Knibbs, Luke D.; Morawska, Lidia; Dharmage, Shyamali C.; Heinrich, Joachim; Jalaludin, Bin; Lin, Shao; Guo, Yuming; Xu, Shu-Li; Wu, Qi-Zhen; Chen, Gongbo; Yang, Bo-Yi; Zeng, Xiao-Wen; Yu, Yunjiang; Hu, Li-Wen und Dong, Guang-Hui (2021): Ultrafine particles, blood pressure and adult hypertension: a population-based survey in Northeast China. In: Environmental Research Letters, Bd. 16, Nr. 9, 94041

Abstract

The toxicity of ultrafine particles (UFPs) on blood pressure (BP) has not been well studied. We aimed to evaluate the associations of long-term UFP exposure with different components of BP and the risk of prehypertension/hypertension. We included a total of 24 845 Chinese adults (18-74 years old) in a cross-sectional survey (Liaoning province, China). The 4 year (2006-2009) average concentrations of UFP was estimated using a chemical transport model. We measured systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP) and pulse pressure (PP), prehypertension and hypertension. We used a generalized linear mixed model to examine the associations while controlling for important individual covariates. One unit (1 mu g m(-3)) increase in UFP was associated with an increase in SBP of 1.52 mm Hg [95% confidence interval (CI): 0.48-2.55], DBP of 0.55 mm Hg (95% CI: 0.01-1.08) in DBP, MAP of 0.92 mm Hg (95% CI: 0.23-1.61) and PP of 0.62 mm Hg (95% CI: 0.05-1.20). The UFP-BP associations were stronger in women than in men. One unit increase in UFP was associated with an increased risk of hypertension and prehypertension (OR = 1.23, 95% CI: 1.09-1.38;OR = 1.12, 95% CI: 1.04-1.21) compared to normotension group, and these associations were stronger in overweight/obese participants. Our study showed that long-term exposure to UFP was associated with elevated BP and higher odds of hypertension. These findings suggest that strategies to monitor and reduce UFPs, which are not a regulated pollutant, could have beneficial cardiovascular effects.

• Dokumententyp: Zeitschriftenartikel
• Fakultät: Medizin
• Themengebiete: 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit
• ISSN: 1748-9326
• Sprache: Englisch