Anti-MOG antibody-associated disorders: differences in clinical profiles and prognosis in Japan and Germany

Liu, Jia; Mori, Masahiro; Zimmermann, Hanna; Brandt, Alexander; Havla, Joachim; Tanaka, Satoru; Sugimoto, Kazuo; Oji, Satoru; Uzawa, Akiyuki; Asseyer, Susanna; Cooper, Graham; Jarius, Sven; Bellmann-Strobl, Judith; Ruprecht, Klemens; Siebert, Nadja; Masuda, Hiroki; Uchida, Tomohiko; Ohtani, Ryohei; Nomura, Kyoichi; Meinl, Edgar; Kuempfel, Tania; Paul, Friedemann und Kuwabara, Satoshi (2021): Anti-MOG antibody-associated disorders: differences in clinical profiles and prognosis in Japan and Germany. In: Journal of Neurology Neurosurgery and Psychiatry, Bd. 92, Nr. 4: S. 377-383

Abstract

Background Neurological disorders with IgG antibodies against myelin-oligodendrocyte glycoprotein (MOG-IgG) have been increasingly recognised as a new type of neuroinflammatory disorder. Objective The study aimed to identify regional and ethnic differences in clinical profiles of MOG-IgG-associated disorders between East Asian (Japanese) and Caucasian (German) patients. Methods Demographic, clinical and therapeutic data from 68 MOG-IgG-positive adults were collected (Japanese, n=44;German, n=24). Results Age and sex were similar between cohorts, with optic neuritis occurring most frequently at onset (Japanese: 61%;German: 58%). However, Japanese patients had a lower annualised relapse rate (0.4 vs 0.8, p=0.019;no relapse, 64% vs 25%, p=0.002) and lower Expanded Disability Status Scale score at the last visit (1.0 vs 2.0;p=0.008), despite similar follow-up periods (mean, 73.9 months vs 73.4 months), than those of German patients, respectively. Cerebral syndromes were more common (27% vs 4%;p=0.021) and myelitis less common (21% vs 50%;p=0.012) in Japanese than in German patients, respectively. Japanese patients were more commonly treated with long-term corticosteroids (73%), whereas German patients were more commonly treated with rituximab or other immunosuppressants (63%). Conclusions Among patients with MOG-IgG, Japanese tended to have a monophasic milder disease, whereas the majority of German patients had a relapsing course and more frequent myelitis, findings compatible with neuromyelitis optica spectrum disorder. Although the attack-prevention treatment regimens were considerably different, genetic and environmental factors may be important to determine clinical phenotypes and disease activity.

• Dokumententyp: Zeitschriftenartikel
• Fakultät: Medizin
• Themengebiete: 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit
• ISSN: 0022-3050
• Sprache: Englisch