Portal and hepatic vein embolization

Masthoff, Max; Katou, Shadi; Koehler, Michael; Schindler, Philipp; Heindel, Walter; Wilms, Christian; Schmidt, Hartmut H.; Pascher, Andreas; Struecker, Benjamin; Wildgruber, Moritz und Morgul, Haluk (2021): Portal and hepatic vein embolization. In: Zeitschrift für Gastroenterologie, Bd. 59, Nr. 1: S. 35-42

Abstract

Purpose To analyze safety and effectiveness of simultaneous portal and hepatic vein embolization (PHVE) or sequential hepatic vein embolization (HVE) compared to portal vein embolization (PVE) for future remnant liver (FRL) hypertrophy prior to major hepatic surgery. Methods Patients undergoing PVE, PHVE or HVE at our tertiary care center between 2018 and 2020 were retrospectively included. FRLV, standardized FRLV (sFRLV) and sFRLV growth rate per day were assessed via volumetry, as well as laboratory parameters. Results 36 patients (f = 15, m = 21;median 64.5 y) were included, 16 patients received PHVE and 20 patients PVE, of which 4 received sequential HVE. Significant increase of FRLV was achieved with both PVE and PHVE compared to baseline (p < 0.0001). sFRLV growth rate did not significantly differ following PHVE (2.2 +/- 1.2 %/d) or PVE (2.2 +/- 1.7 %/d, p = 0.94). Left portal vein thrombosis (LPVT) was observed after PHVE in 6 patients and in 1 patient after PVE. Sequential HVE showed a considerably high growth rate of 1.42 +/- 0.45%/d after PVE. Conclusion PHVE effectively induces FRL hypertrophy but yields comparable sFRLV to PVE. Sequential HVE further induces hypertrophy after insufficient growth due to PVE. Considering a potentially higher rate of LPVT after PHVE, PVE might be preferred in patients with moderate baseline sFRLV, with optional sequential HVE in non-sufficient responders.

• Dokumententyp: Zeitschriftenartikel
• Fakultät: Medizin
• Themengebiete: 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit
• ISSN: 0044-2771
• Sprache: Englisch