Editorial: Light shielding of bags and tubing used for parenteral nutrition of infants

Mihatsch, Walter A. und Koletzko, Berthold (2021): Editorial: Light shielding of bags and tubing used for parenteral nutrition of infants. In: Current Opinion in Clinical Nutrition and Metabolic Care, Vol. 24, No. 3: pp. 236-239

Abstract

Purpose of review In July 2019, the Pharmacovigilance Risk Assessment Committee (PRAC) of the European Medicines Agency (EMA) recommended light protection of all parenteral nutrition (PN) solutions containing amino acids (AA) and/or lipids, with or without admixture of vitamins or trace elements, during administration for preterm infants, term infants and children less than 2 years of age. The aim of the present paper was to review the available evidence and to provide recommendations for in hospital and home PN light protection in children. Recent findings Lipid emulsions and multivitamins are susceptible to photooxidation and generation of oxidation products. There is no conclusive evidence to justify recommending light protection for PN solutions without lipid emulsions and/or vitamins during administration (solutions containing e.g. AA, glucose, electrolytes, or trace elements). Lipid emulsions and/or vitamins containing PN solutions should be protected from light during administration (bags and tubing) to reduce the generation of oxidation products.

• Item Type: Journal article
• Faculties: Medicine
• Subjects: 600 Technology > 610 Medicine and health
• ISSN: 1363-1950
• Language: English