Abstract
Interferons (IFNs) are cytokines that play an important role in the immune response of animals and humans. A number of studies reviewed here have evaluated the use of human, canine and feline IFNs as treatments for infectious, inflammatory and neoplastic disease in dogs and cats. Recombinant canine IFN-gamma is deemed an efficacious therapy for canine atopic dermatitis. Recombinant feline IFN-omega is effective against canine parvoviral enteritis and has also been recommended for canine atopic dermatitis. Based on limited evidence, recombinant canine IFN-alpha could be a topical treatment option for dogs with gingivitis and keratoconjunctivitis sicca. Conclusive evidence is lacking for other diseases and large randomised controlled trials are needed before IFNs can be recommended for other indications. (C) 2021 Published by Elsevier Ltd.
| Item Type: | Journal article |
|---|---|
| Faculties: | Veterinary Medicine > Centre for Clinical Veterinary Medicine |
| Subjects: | 600 Technology > 610 Medicine and health |
| ISSN: | 1090-0233 |
| Language: | English |
| Item ID: | 100714 |
| Date Deposited: | 05. Jun 2023, 15:35 |
| Last Modified: | 08. Apr 2024, 14:04 |
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