Abstract
The group of neutrophilic dermatoses includes various non-infectious diseases characterised by an accumulation of neutrophilic granulocytes in the skin. The clinical appearance of these dermatoses is diverse and ranges from sterile pustules to superficial or deep tissue infiltration and necrosis. The skin lesions are defined histopathologically by a diffuse infiltrate of neutrophilic granulocytes without evidence of infection. Evidence suggests a pathogenetic role of selected proinflammatory cytokines of the interleukin (IL)-1 cytokine family, leading to sterile neutrophil-rich inflammation of the skin. The classification of neutrophil dermatoses is histopathologically based on the cutaneous localisation of neutrophil accumulation. The article provides an overview of the most important clinical features of neutrophilic dermatoses, their causes and treatment options.
| Item Type: | Journal article |
|---|---|
| Faculties: | Medicine |
| Subjects: | 600 Technology > 610 Medicine and health |
| ISSN: | 0340-2541 |
| Language: | German |
| Item ID: | 100833 |
| Date Deposited: | 05. Jun 2023 15:36 |
| Last Modified: | 17. Oct 2023 15:05 |
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