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Offenbaecher, Martin; Kohls, Niko; Ewert, Thomas; Sigl, Claudia; Hieblinger, Robin; Toussaint, Loren L.; Sirois, Fuschia; Hirsch, Jameson; Vallejo, Miguel A.; Kramer, Sybille; Rivera, Javier; Stucki, Gerold; Schelling, Joerg and Winkelmann, Andreas (2021): Pain is not the major determinant of quality of life in fibromyalgia: results from a retrospective real world data analysis of fibromyalgia patients. In: Rheumatology International, Vol. 41, No. 11: pp. 1995-2006

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Objective To identify correlates of quality of life (QoL) measured with the Quality of Life Scale (QOLS) in participants of a multidisciplinary day hospital treatment program for fibromyalgia (FM). Methods In this cross-sectional, observational study, real world data from 480 FM patients including socio-demographics, pain variables and questionnaires such as the SF-36, Beck Depression Inventory (BDI), Multiphasic Pain Inventory (MPI), SCL-90-R and others were categorized according to the components (body structure and function, activities and participation, personal factors, environmental factors) of the International Classification of Functioning (ICF). For every ICF component, a linear regression analysis with QOLS as the dependent variable was computed. A final comprehensive model was calculated on the basis of the results of the five independent analyses. Results The following variables could be identified as main correlates for QoL in FM, explaining 56% of the variance of the QOLS (subscale/questionnaire and standardized beta in parenthesis): depression (- 0.22), pain-related interference with everyday life (- 0.19), general activity (0.13), general health perception (0.11), punishing response from others (- 0.11), work status (- 0.10), vitality (- 0.11) and cognitive difficulties (- 0.12). Pain intensity or frequency was not an independent correlate. Conclusions More than 50% of QoL variance could be explained by distinct self-reported variables with neither pain intensity nor pain frequency playing a major role. Therefore, FM treatment should not primarily concentrate on pain but should address multiple factors within multidisciplinary therapy.

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