Cognitive profiles of patients with mild cognitive impairment due to Alzheimer's versus Parkinson's disease defined using a base rate approach: Implications for neuropsychological assessments

Ophey, Anja; Wolfsgruber, Steffen; Roeske, Sandra; Polcher, Alexandra; Spottke, Annika; Frolich, Lutz; Hull, Michael; Jessen, Frank; Kornhuber, Johannes; Maier, Wolfgang; Peters, Oliver; Ramirez, Alfredo; Wiltfang, Jens; Liepelt-Scarfone, Inga; Becker, Sara; Berg, Daniela; Schulz, Jorg B.; Reetz, Kathrin; Wojtala, Jennifer; Kassubek, Jan; Storch, Alexander; Balzer-Geldsetzer, Monika; Hilker-Roggendorf, Rudiger; Witt, Karsten; Mollenhauer, Brit; Trenkwalder, Claudia; Wittchen, Hans-Ullrich; Riedel, Oliver; Dodel, Richard; Wagner, Michael und Kalbe, Elke (2021): Cognitive profiles of patients with mild cognitive impairment due to Alzheimer's versus Parkinson's disease defined using a base rate approach: Implications for neuropsychological assessments. In: Alzheimer'S & Dementia: Diagnosis, Assessment & Disease Monitoring, Bd. 13, Nr. 1, e12223

Abstract

Introduction Large studies on cognitive profiles of patients with mild cognitive impairment (MCI) due to Alzheimer's disease (AD-MCI) compared to Parkinson's disease (PD-MCI) are rare. Methods Data from two multicenter cohort studies in AD and PD were merged using a unified base rate approach for the MCI diagnosis. Cognitive profiles were compared using scores derived from the Consortium to Establish a Registry for Alzheimer's Disease battery. Results Patients with AD-MCI showed lower standardized scores on all memory test scores and a language test. Patients with PD-MCI showed lower standardized scores in a set-shifting measure as an executive task. A cross-validated logistic regression with test scores as predictors was able to classify 72% of patients correctly to AD-MCI versus PD-MCI. Discussion The applied test battery successfully discriminated between AD-MCI and PD-MCI. Neuropsychological test batteries in clinical practice should always include a broad spectrum of cognitive domains to capture any cognitive changes.

• Dokumententyp: Zeitschriftenartikel
• Fakultät: Medizin
• Themengebiete: 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit
• Sprache: Englisch