Activation of 2-Cyclohexenone by BF3 Coordination: Mechanistic Insights from Theory and Experiment

Peschel, Martin T.; Kabacinski, Piotr; Schwinger, Daniel P.; Thyrhaug, Erling; Cerullo, Giulio; Bach, Thorsten; Hauer, Jürgen and Vivie-Riedle, Regina de (2021): Activation of 2-Cyclohexenone by BF3 Coordination: Mechanistic Insights from Theory and Experiment. In: Angewandte Chemie-International Edition, Vol. 60, No. 18: pp. 10155-10163

Abstract

Lewis acids have recently been recognized as catalysts enabling enantioselective photochemical transformations. Mechanistic studies on these systems are however rare, either due to their absorption at wavelengths shorter than 260 nm, or due to the limitations of theoretical dynamic studies for larger complexes. In this work, we overcome these challenges and employ sub-30-fs transient absorption in the UV, in combination with a highly accurate theoretical treatment on the XMS-CASPT2 level. We investigate 2-cyclohexenone and its complex to boron trifluoride and analyze the observed dynamics based on trajectory calculations including non-adiabatic coupling and intersystem crossing. This approach explains all ultrafast decay pathways observed in the complex. We show that the Lewis acid remains attached to the substrate in the triplet state, which in turn explains why chiral boron-based Lewis acids induce a high enantioselectivity in photocycloaddition reactions.

• Item Type: Journal article
• Faculties: Chemistry and Pharmacy
• Subjects: 500 Science > 540 Chemistry
• ISSN: 1433-7851
• Language: English