Abstract
and (chemo)radiation were independent prognostic factors for death or recurrence in multivariate analysis. 2year disease-free survival rates were 59.3% ( -70 yrs), 65.8% (50?69 yrs) and 81.1% (<50 yrs), respectively (p < 0.001). Conclusions. Older women with VSCC present with advanced tumor stages at first diagnosis and have an increased risk of recurrence as well as a decreased 2-year DFS in comparison to younger patients. Potential reasons Background. Despite an increasing incidence with simultaneous decreasing age of onset, vulvar squamous cell carcinoma (VSCC) is still a disease that mainly effects the elderly population. Data on the association of age with prognosis and treatment patterns in VSCC are sparse. Methods. This is an analysis of the AGO-CaRE-1 cohort. Patients with VSCC (FIGO stage >_1B), treated at 29 cancer centers in Germany from 1998 to 2008, were included in a centralized database (n =1618). In this subgroup analysis patients were analyzed according to age [<50 yrs. (n = 220), 50-69 yrs. (n = 506), >_70 yrs. (n = 521)] with regard to treatment patterns and prognosis. Only patients with documented age, surgical groin staging and known nodal status were included (n = 1247). Median follow-up was 27.5 months. Results. At first diagnosis, women >_70 yrs. presented with more advanced tumor stages (<0.001), larger tumor diameter (<0.001), poorer ECOG status (<0.001), more frequent HPV negative tumors (p = 0.03) as well as a higher rate of nodal involvement (<0.001). Disease recurrence occurred significantly more often in elderly patients (p = 0.001) and age as well as ECOG status, microscopic residual resection, tumor stage, grading,and (chemo)radiation were independent prognostic factors for death or recurrence in multivariate analysis. 2-year disease-free survival rates were 59.3% (>-70 yrs), 65.8% (50-69 yrs) and 81.1% (<50 yrs), respectively (p < 0.001). Conclusions. Older women with VSCC present with advanced tumor stages at first diagnosis and have an in-creased risk of recurrence as well as a decreased 2-year DFS in comparison to younger patients. Potential reasons could be self-awareness and/or more aggressive tumor biology due to HPV independent disease. (c) 2021 ELSEVIER. All rights reserved.
| Dokumententyp: | Zeitschriftenartikel |
|---|---|
| Fakultät: | Medizin |
| Themengebiete: | 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit |
| ISSN: | 0090-8258 |
| Sprache: | Englisch |
| Dokumenten ID: | 101243 |
| Datum der Veröffentlichung auf Open Access LMU: | 05. Jun. 2023, 15:37 |
| Letzte Änderungen: | 17. Okt. 2023, 15:07 |
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