Logo Logo
Switch Language to German

Puhr-Westerheide, D.; Westphalen, C. B. and Streitparth, F. (2021): Integrierte Diagnostik beim CUP-Syndrom. Computertomographie, Magnetresonanztomographie und bildgesteuerte Biopsie. In: Onkologe, Vol. 27, No. 7: pp. 628-636

Full text not available from 'Open Access LMU'.


Background. Cancer of unknown primary (CUP) represents a metastatic tumor disease with histologically or cytologically confirmed malignancy but without detection of a primary tumor in the diagnostic evaluation. This common tumor entity (3-5% of all malignancies) can involve different organs and body regions. For the diagnostic workup, clinical presentation and laboratory findings as well as radiological imaging and tumor biopsy for histopathological analyses are key. Objective. The aim is to provide an overview of the role of imaging, as well as the significance of imaging-guided biopsy in CUP. Materials and methods. A selective review of the literature using PubMed including reviews and clinical studies focusing on diagnostic evaluation of CUP, taking into consideration the current guidelines and recommendations of expert associations, is presented. Results and conclusion. Computed tomography (CT) imaging of the chest, abdomen and pelvis is recommended by guidelines as basic diagnostics for the evaluation of CUP. Contrast-enhanced MRI with high soft-tissue resolution is particularly important for tumor detection of the neck, breast cancer, brain metastases, prostate cancer, cancer of the ovaries and the female genital organs, the kidneys, as well as the detection of liver metastases. A urographic phase supports the detection of tumors of the urinary system. The CT-guided biopsy also allows targeted tissue sampling from almost all body regions with a high strike rate and low complication rates. The extraction of sufficient amounts of tissue for further histopathological evaluation is essential for classification of the primary tumor.

Actions (login required)

View Item View Item